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Analysis of a genome-wide microscopy screen for regulators of lysosomal stability

Lysosomes are cell organelles in charge of degradation. Lysosomal membrane permeabilization (LMP) causes the leakage of cathepsins and other digestive enzymes into the cytosol from lysosomal cavities. This usually causes the initiation of cell death. LMP can be triggered by many stimuli and this could potentially be used in new therapeutic approaches for removing cancer cells. However, excessive L

Diophantine Approximation and Dynamical Systems

The subject of diophantine approximation is a classical mathematic problem, as old as it is well studied. There are many different texts describing its connection to more modern areas of study, but few which do so with the aim of exploring the connections themselves. This paper aims to serve as an introduction to diophantine approximation, and to expose some properties common between two dynamical

Grannskapsfabriken - Ett undersökande arbete om delande och kollektiva lösningar (ur ett bostads- och ett kvartersperspektiv)

The essay aims to examine alternative forms of housing, especially collective solutions and to design a cohousing project. The idea is to broaden our perception of housing and further study the possibilities of cohousing in relation to the more complex needs and different lifestyle of today. The housing market of today is still based upon the idea of an autonomous nuclear family with a lot of priv

Att gräva där man står - en etnologisk studie om upplevelser av landsbygdsbaserad självhushållning

This paper explores the process of transitioning to a rural, self-sustainable lifestyle in terms of ecological sustainability and geographical place, while focusing on how these concepts serve to motivate change and create a sense of purpose. It further analyzes how aspects of structural power may facilitate or impede the transition into self-sufficiency. The study consists of ethnographically ga

Vi mot Dem

Syfte: Syftet med uppsatsen är att utveckla förståelsen för den påverkan som skiftande styrning har på anställda inom en organisation. Metod: Abduktivt tillvägagångssätt. Totalt 13 semistrukturerade kvalitativa intervjuer på ett fallföretag. Teoretiska perspektiv: Det huvudsakliga perspektivet för analysen är social identitetsteori. En litteraturgenomgång av traditionell och nutida forskning angPurpose: The purpose of the thesis is to develop an understanding of the impact that varied organizational control has on employees within an organization. Methodology: Abductive approach. A total of 13 semi-structured qualitative interviews at a case company. Theoretical perspectives: The main perspective is through the social identity theory. A literature review of traditional and contemporary

Upplevelsen av att leva med venösa bensår

Bakgrund: De individer som drabbas av ett venöst bensår kommer troligen att leva med det under en lång tid. Det är även ett välkänt problem att dessa individer upplever svårigheter i sin vardag samt det är ett komplext problem som inte endast kan lösas genom såromläggningar. Syfte: Att beskriva personers upplevelser av att leva med ett venöst bensår. Metod: 12 kvalitativa studier valdes ut och en

Grammatiska och didaktiska perspektiv på partikeln le i rikskinesiska – en jämförande studie

The recent addition of Modern Standard Chinese (MSC) as an elective language in Swedish elementary and high school ('Moderna Språk') has brought the teaching of MSC particle le to the fore. Le occurs either affixed to a verb (le1) or as a sentence-final particle (le2) and is a frequently used grammatical device in MSC with a great number of various functions. At the same time, coexistent a

History as an argument for the future : A study of Nick Clegg’s and Nigel Farage’s use of history during the United Kingdom’s 2016 EU referendum

This thesis is concerned with history within Nick Clegg’s and Nigel Farage’s political discourse during the six months leading up to the 2016 referendum on the United Kingdom’s membership in the European Union. Using Thematic Analysis combined with Klas-Göran Karlsson’s typology of the use of history, Jörn Rüsen’s typology of historical narrative and drawing on the theoretical framework of histori

Image formation of the place via Instagram photographs

Images hide the meaning that words cannot convey. With increased interest in addressing place branding in social media setting, the importance of photographs in image making of the place beforehand from consumers point of view seem to lack interest. Therefore, the aim of this study is to explore Instagram photography in image formation of the place. We love Lithuania serves as a case where ZMET te

LINE

The project started with the question “why wouldn’t a disabled or old person want it to look nice at home?” Many assistive products on the market are designed in a way that doesn’t fit the interior trends, which is an issue for several reasons. By the aesthetics assistive products possess, the users get labeled as people who are sick and abnormal. The brief was then created and the goal was to des

Production of small, switchable, bispecific antibodies with EF1 and EF2-tagged scFvs

Producing small, bispecific antibodies Proteins are molecules which come in all shapes and sizes, found in every living being. They are translated from the DNA found in the cells of every organism, and every single protein has different characteristics, which allow them to carry out a number of varied functions. Some proteins emit colors, some proteins move ions in the cell, some proteins receive

The Humane School

My diploma project is a design proposal for a Rudolf Steiner School in Sirende, a village 12 km outside Kitale Town, Kenya. On Initiative taken by the anthroposophical association Föreningen Sofia in Sweden, a Steiner school opened in Sirende in year 2008. Today the school is in a very bad condition with over crowded classrooms and poor sanitary conditions. The need for a new school building is ur

Targeting SphK2 in hypertension-induced neurodegeneration

Does treating high blood pressure improve neurodegeneration High blood pressure, also called hypertension could damage the brain. Our research tries to understand how lowering blood pressure affects the hypertensive brain. Hypertension is the disease that people have abnormally high blood pressure. Nowadays, 1 in 5 people worldwide have hypertension, accounting for 1.13 billion people. This cause

Sex allocation and sex-specific offspring performance under variable food conditions in the color polymorphic tawny owl (Strix aluco)

Previous research into variation in sex allocation strategies in birds has provided evidence for sex ratio adjustments by parents to maximize fitness, based on differences in the costs of producing males and females. Additionally, studies of melanin-based color polymorphism indicate that life history strategies, physiology, and behavior may vary among color variants of the same species. This study

Investigating the use of radiative heat panels to enhance perceived threat of fire in VR

The purpose of this report was to develop and evaluate new solutions to improve the perception of fire threat in virtual reality experiments. Thermal heat have been identified as a stimulus that modern day virtual reality experiments don’t take into account that would likely affect a person in a real life fire evacuation scenario. The objective of this report was to successfully implement thermal

Att se sanningen i vitörat. En diskursanalys av debatten om bildbearbetning i kölvattnet av utställningen The thin line

This thesis examines the debate that followed the 2019 exhibition The Thin Line at Dunkers kulturhus, when it became known that one of the photographs had been digitally altered. The aim of the study is to contribute to an understanding of our norms and attitudes to- wards the photographic image and it’s genres. The questions asked are: What views on photo- graphic truth are represented in the deb

Hav & land : en fallstudie om ekologisk hållbarhet i marina miljöer

This bachelor thesis aims to explore human activities in marine environments, and further reflect on how they are connected to sustainable development from an ecological standpoint. It will do so through a case study of the Danish-Swedish channel Öresund, also known as the shortest shipping route from the North Sea and the Atlantic and to the Baltic Sea. Together with the Great and Little Belt cha

Do Regional Politics Matter for Regional Growth?

This paper estimates the relationship between political instability and economic growth at the regional level. A panel of Swedish regions over the time frame 1994-2018 is used to conduct the empirical analysis. The empirical analysis consists of regressing regional growth rates in GDP per worker on a measure of political instability and a set of control variables. Growth rates are measured over a