Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) X BMI and SN

We present a fast algorithm for the calculation of elastostatic fields in two-dimensional assemblies of elastic grains, separated by sharp grain boundaries. The algorithm uses an integral equation approach, combined with the fast multipole method and recursive compression to resolve stress concentrations also very close to grain boundary junctions. Singular basis functions on analytic form are not

We present a framework for computing optimal transformations, aligning one point set to another, in the presence of outliers. Example applications include shape matching and registration (using, for example, similarity, affine or projective transformations) as well as multiview reconstruction problems (triangulation, camera pose etc.). While standard methods like RANSAC essentially use heuristics

Recent studies revealed layers of enhanced aerosol scattering in the upper troposphere and lower stratosphere over Asia (Asian Tropopause Aerosol Layer (ATAL)) and North America (North American Tropospheric Aerosol Layer (NATAL)). We use a sectional aerosol model (Community Aerosol and Radiation Model for Atmospheres (CARMA)) coupled with the Community Earth System Model version 1 (CESM1) to explo

A critical review of a book on guilt and moral in the relations of Sweden to Nazi Germany.

Methods. Blood samples from patients with IgAN (n = 21) and age-matched controls (n = 83) were assayed by ELISA to detect an IgG antibody response to the IgA-BRs of the M4, M22 and M60 proteins. Antibodies were assayed for each IgA-BR separately and the results were combined. Results. Antibody levels to the IgA-BRs were significantly higher in IgAN patients than controls (P = 0.016), particularly

When PGSE NMR is applied to water in microheterogeneous materials such as liquid crystals, foodstuffs, porous rocks, and biological tissues, the signal attenuation is often multi-exponential, indicating the presence of pores having a range of sizes or anisotropic domains having a spread of orientations. Here we modify the standard PGSE experiment by introducing low-amplitude harmonically modulated

Newton's Law of Gravitation has been tested at small values a of the acceleration, down to a a parts per thousand 10(-10) ms(-2), the approximate value of MOND's constant a (0). Within experimental errors no deviations from Newton's Law were found. A comparison with six versions of the MOND interpolation function is given. Under the assumptions made in this paper one of the versions can be exclude

This paper describes the development and performance of the first fructose biosensor based on a commercial screen-printed graphene electrode (SPGE). The electrode was modified with an osmium-polymer, which allowed the efficient wiring of the enzyme fructose dehydrogenase (FDH). The immobilization of both osmium-polymer and FDH was realized in an easy way. Aliquots of 10 mu L, Os-polymer and 10 mu

Introduction to special edition of Statsvetenskaplig tidskrift (Journal of Political Science) on politics and film.

A highly selective, interference free biosensor for the measurement of fructose in real syrup samples was developed. The assay is based on the phosphorylation of D(-)fructose to fructose-6-phosphate by hexokinase and subsequent conversion of fructose-6-phosphate to fructose-1,6-biphosphate by fructose-6-phosphate-kinase. The heat liberated in the second reaction is monitored using an enzyme thermi

The aim of the work presented in this thesis was to investigate how transvaginal ultrasound examination of non-pregnant women could be used to visualize and assess caesarean hysterotomy scars, and to evaluate the risk of uterine rupture in subsequent pregnancies. The diagnostic value of transvaginal ultrasound for correct evaluation of caesarean hysterotomy scars was determined, and the prevalence

Background: Special AT-rich sequence-binding protein 1 (SATB1) is a global gene regulator that has been reported to confer malignant behavior and associate with poor prognosis in several cancer forms. SATB1 expression has been demonstrated to correlate with unfavourable tumour characteristics in rectal cancer, but its association with clinical outcome in colorectal cancer (CRC) remains unclear. In

The structures of interfacial layers formed from mixtures of comb polymers, comprising a high charge density cationic backbone and poly(ethylene oxide) (PEO) side-chains, with the anionic surfactant sodium dodecyl sulfate (SDS) at the silica/water interface, have been determined using neutron reflectivity measurements. The use of mixtures in which only the isotopic composition of the surfactant is

Wild dabbling ducks (genus Anas) are the main reservoir for influenza A virus (IAV) in the Northern Hemisphere. Current understanding of disease dynamics and epidemiology in this virus-host system has primarily been based on population-level surveillance studies and infection experiments conducted in laboratory settings. Using a combined experimental-natural approach with wild-strain captive malla

Biotic communities in Northeast Greenland have an insular character as a consequence of the complex geomorphologic nature of the ice-free land and its interdigitation with glacial ice and the sea. Post Pleistocene movements of most plants and animals into the region have generally followed East and North Greenland coastal routes, and the majority of the plants have North American affinities. Clima

Radionuclide therapy aims to treat malignant diseases by systemic administration of radiopharmaceuticals, often using carrier molecules such as peptides and antibodies. The radionuclides used emit electrons or alpha particles as a consequence of radioactive decay, thus leading to local energy deposition. Administration to individual patients can be tailored with regards to the risk of toxicity in

Recent experimental studies show that oppositely charged proteins can self-assemble to form seemingly stable microspheres in aqueous salt solutions. We here use parallel tempering Monte Carlo simulations to study protein phase separation of lysozyme/alpha-lactalbumin mixtures and show that anisotropic electrostatic interactions are important for driving protein self-assembly. In both dilute and co