Developing systems to identify the cell type-specific functions regulated by genes linked to type 2 diabetes (T2D) risk could transform our understanding of the genetic basis of this disease. However, in vivo systems for efficiently discovering T2D risk gene functions relevant to human cells are currently lacking. Here we describe powerful interdisciplinary approaches combining Drosophila genetics

Partially premixed combustion with low octane fuel aims to reduce NOx and soot emission simultaneously without fuel consumption penalty. Cylinder pressure based combustion phase control is an essential technology for partially premixed combustion. A novel closed-loop combustion phase control strategy for multiple combustion modes is proposed in the current study. The combustion modes are classifie

Ghrelin and obestatin are two gastrointestinal peptides, derived from a common precursor. Expression of both peptides have been found in breast cancer tissue and ghrelin has been associated with breast cancer development. Ghrelin expression is associated with longer survival in women diagnosed with invasive and node negative breast cancer. The clinical implications of the peptide expression in mal

Fetal growth may be impaired by poor placental function or maternal conditions, each of which can influence the transfer of nutrients and oxygen from the mother to the developing fetus. Large-scale studies of metabolites (metabolomics) are key to understand cellular metabolism and pathophysiology of human conditions. Herein, maternal and cord blood plasma samples were used for NMR-based metabolic

Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and a replication series, totalling 9974 MM cases and 247,556 controls of European ancestry. Collectively, these data provide evidence for six new MM risk loci, bringing the t

Home energy management systems (HEMS), providing energy feedback and smart features through in-home displays, have the potential to support more sustainable household decisions concerning energy consumption. However, recent findings from European smart metering trials have reduced the optimism, suggesting only modest savings from energy feedback. In this paper, we investigate the potential of HEMS

A combined measurement of differential and inclusive total cross sections of Higgs boson production is performed using 36.1 fb−1 of 13 TeV proton–proton collision data produced by the LHC and recorded by the ATLAS detector in 2015 and 2016. Cross sections are obtained from measured H→γγ and H→ZZ⁎→4ℓ event yields, which are combined taking into account detector efficiencies, resolution, acceptances

In this paper, we study sliding window decoding of braided convolutional codes (BCCs) in the context of a streaming application, where decoder error propagation can be a serious problem. A window extension algorithm and a resynchronization mechanism are introduced to mitigate the effect of error propagation. In addition, we introduce a soft bit-error-rate stopping rule to reduce computational comp

A vast majority of Science, Technology, Engineering, Mathematics (STEM) courses and pedagogical frameworks concentrate on teaching the fundamental concepts and theoretical underpinnings of the tools related to the subject. While this aspect is important, we recognize that the teaching methods in a majority of the STEM courses today are broken; there is a major discrepancy between the skills and mi

Understanding the mechanical behaviour of porous rocks and how this influences the fluid flow is key in a number of resource engineering challenges, in particular hydrocarbon production and CO2 sequestration. Deformation in these porous materials is, in general, not homogeneous, as deformation localises into narrow shear or compaction bands, which might then evolve into fractures. These local defo

We present a non-resonant, dual band circular polarization selective structure (CPSS) for satellite communication applications in the K- and Ka-bands. The structure consists of multiple layers of cascaded anisotropic sheets, with printed meander lines, separated by low permittivity spacers. It reflects right handed circular polarization and transmits left handed circular polarization in the lower

This work presents a methodology for modeling, designing and scaling the electromagnetic, mechanical and thermal characteristics of the main components in an electric powertrain (excluding the battery) i.e. power electronics converter, electrical machine and mechanical transmission. Additionally, a framework for estimating the cost of these components is described. This framework takes into consid

We give a method for designing a mechanical impedance to suppress the propagation of disturbances along a chain of masses. The key feature of our method is that it is scale free. This means that it can be used to give a single, fixed, design, with provable performance guarantees in mass chains of any length. We illustrate the approach by designing a bidirectional control law in a vehicle platoon i

BACKGROUND: Patients with acute coronary occlusion (ACO) may not only have ischemia-related ST-segment changes but also changes in the QRS complex. It has recently been shown in dogs that a greater ischemic QRS prolongation (IQP) during ACO is related to lower collateral flow. This suggests that greater IQP could indicate more severe ischemia and thereby more rapid infarct development. Therefore,

Many biopharmaceuticals (BPs) are known to be immunogenic in the clinic, which can result in modified pharmacokinetics, reduced efficacy, allergic reactions and anaphylaxis. During recent years, several technologies to predict immunogenicity have been introduced, but the predictive value is still considered low. Thus, there is an unmet medical need for optimization of such technologies. The genera

In a previous study, we showed that the Ly6G(-)CD11b(+) blood monocytes residing in naïve mice are intrinsically immunosuppressive and that loss of this suppressive function may contribute to the development of autoimmunity in experimental autoimmune encephalomyelitis (EAE), a murine model of human multiple sclerosis. Here we report that mice treated with a modified superantigen coupled to myelin

Tolerance induction, and thus prevention of autoimmunity, is linked with the amount of self-antigen presented on thymic stroma. We describe that intrathymic (i.t.) delivery of the autoantigen, myelin oligodendrocyte glycoprotein (MOG), via a lentiviral vector (LV), led to tolerance induction and prevented mice from developing fulminant experimental autoimmune encephalomyelitis (EAE). This protecti