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Symptoms 10-17 years after breast cancer radiotherapy data from the randomised SWEBCG91-RT trial

Background: Postoperative radiotherapy decreases the risk for local and improves overall survival in women with breast cancer. We have limited information on radiotherapy-induced symptoms 10-17 years after therapy. Material and methods: Between 1997 and 1997, women with lymph node-negative breast cancer were randomised in a Swedish multi-institutional trial to breast conserving surgery with or wit

Modeling Solute Transport in Volcanic Ash Soils with Cation Exchange and Anion Retardation

Groundwater under agricultural lands is often contaminated by nitrate. In southern Japan, aquifers are covered by volcanic ash soils that can leach nitrate to the groundwater. In this study, column experiments using two volcanic ash soils (Kuroboku and Akahoya) were carried out. A mixed solution of KNO3 and K2SO4 was used in the leaching experiments. Based on the experiments, a reactive transport

Managing Haemophilia for Life: 4th Haemophilia Global Summit

The 4th Haemophilia Global Summit was held in Potsdam, Germany, in September 2013 and brought together an international faculty of haemophilia experts and delegates from multidisciplinary backgrounds. The programme was designed by an independent Scientific Steering Committee of haemophilia experts and explored global perspectives in haemophilia care, discussing practical approaches to the optimal

Positron emission tomography in malignancies of the liver, pancreas and biliary tract - indications and potential pitfalls.

Abstract Malignancies of the hepato-pancreatico-biliary (HPB) system are relatively common and generally characterized by a dismal prognosis. Positron emission tomography (PET) is a functional imaging technique that has emerged as an important modality in oncological decision-making. The principal radiopharmaceutical in PET imaging is the glucose analog (18)F-fluorodeoxyglucose, which is able to d

STrengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology STROBE-ME: an extension of the STROBE statement

Advances in laboratory techniques have led to a rapidly increasing use of biomarkers in epidemiological studies. Biomarkers of internal dose, early biological change susceptibility and clinical outcomes are used as proxies for investigating the interactions between external and/or endogenous agents and body components or processes. The need for improved reporting of scientific research led to infl

Impact of the lesion procedure on the profiles of motor impairment and molecular responsiveness to L-DOPA in the 6-hydroxydopamine mouse model of Parkinson's disease.

6-Hydroxydopamine (6-OHDA) lesions are being used in the mouse for basic research on Parkinson's disease and L-DOPA-induced dyskinesia. We set out to compare unilateral lesion models produced by intrastriatal or intramesencephalic injections of a fixed 6-OHDA concentration (3.2μg/μl) in C57BL/6 mice. In the first experiment, toxin injections were performed either at two striatal coordinates (1 or

Corporate Community Responsibility as an Outcome of Individual Embeddedness

Purpose:The purpose of this article is to improve our understanding of the nature of socialresponsibility in actual practices and, specifically, the influence of individuals on these processes.Design/methodology/approach:An abductive approach is applied (Alvesson and Sköldberg 1994), i.e. theory is developed by moving between theory and four empirical cases. The stories highlight theimportance of

DNAJB6 is a peptide-binding chaperone which can suppress amyloid fibrillation of polyglutamine peptides at substoichiometric molar ratios.

Expanded polyglutamine (polyQ) stretches lead to protein aggregation and severe neurodegenerative diseases. A highly efficient suppressor of polyQ aggregation was identified, the DNAJB6, when molecular chaperones from the HSPH, HSPA, and DNAJ families were screened for huntingtin exon 1 aggregation in cells (Hageman et al. in Mol Cell 37(3):355-369, 2010). Furthermore, also aggregation of polyQ pe

Metacognition and Learning Journals in Higher Education

The studies in higher education have its natural focus on the subject matters of study. This also holds for the master program Technology Management (TM). In addition it is important to complement the students’ academic knowledge with insights about metacognition, i.e. knowledge and understanding of themselves and their own behaviour. The introduction of so-called Learning Journals has proved to b

A multicenter observational safety study in Swedish children and adolescents using insulin detemir for the treatment of type 1 diabetes.

This 26-wk observational study in children and adolescents with type 1 diabetes (T1D) in Sweden investigated the safety and efficacy of insulin detemir (IDet) in newly diagnosed (ND) patients and those with established diabetes (ED) switching to IDet. A total of 159 patients initiated IDet as part of basal-bolus therapy, 59 in the ND stratum (mean age 9.7 yr) and 97 in the ED stratum (mean age 12.

The activation loop tyrosine 823 is essential for the transforming capacity of the c-Kit oncogenic mutant D816V.

Oncogenic c-Kit mutations have been shown to display ligand-independent receptor activation and cell proliferation. A substitution of aspartate to valine at amino acid 816 (D816V) is one of the most commonly found oncogenic c-Kit mutations and is found in >90% of cases of mastocytosis and less commonly in germ-cell tumors, core-binding factor acute myeloid leukemia and mucosal melanomas. The mecha

Ernest Gellner’s Use of the Social Sciences in Philosophy

It is well known that Ernest Gellner made substantial use of his knowledge of the social sciences in philosophy. Here I discuss how he used it on the basis of a few examples taken from Gellner’s philosophical output. It is argued that he made a number of highly original “translations”, or re-interpretations, of philosophical theories and problems using his knowledge of the social sciences. While t

Rao-Blackwellized Particle Filters with Out-of-Sequence Measurement Processing

This paper addresses the out-of-sequence measurement (OOSM) problem for mixed linear/nonlinear state-space models, which is a class of nonlinear models with a tractable, conditionally linear substructure. We develop two novel algorithms that utilize the linear substructure. The first algorithm effectively employs the Rao-Blackwellized particle filtering framework for updating with the OOSMs, and i

The FERRUM project: metastable lifetimes in Cr II

Parity forbidden radiative transitions from metastable levels are observed in spectra of low-density astrophysical plasmas. These lines are used as probes of the physical conditions, made possible due to the long lifetime of their upper level. In a joint effort, the FERRUM project aims to obtain new and accurate atomic data for the iron-group elements, and part of this project concerns forbidden l

Formation of Supported Lipid Bilayers by Vesicle Fusion: Effect of Deposition Temperature

We have investigated the effect of deposition temperature on supported lipid bilayer formation via vesicle fusion. By using several complementary surface-sensitive techniques, we demonstrate that despite contradicting literature on the subject, high-quality bilayers can be formed below the main phase-transition temperature of the lipid. We have carefully studied the formation mechanism of supporte

Evolution of the complex refractive index in the UV spectral region in ageing secondary organic aerosol

The chemical and physical properties of secondary organic aerosol (SOA) formed by the photochemical degradation of biogenic and anthropogenic volatile organic compounds (VOC) are as yet still poorly constrained. The evolution of the complex refractive index (RI) of SOA, formed from purely biogenic VOC and mixtures of biogenic and anthropogenic VOC, was studied over a diurnal cycle in the SAPHIR ph