Background. In some situations, and particularly when intoxications are suspected, it would be advantageous if medicines and drugs of abuse could be swiftly detected in serum or urine. Material and methods. The Department of Clinical Pharmacology at St. Olav University Hospital has since 2004 been developing a comprehensive toxicology service (at all hours 7-days/week) for immediate quantitative a

This study investigated data obtained from whole blood fatty acid (FA) composition of 3476 Norwegian and Swedish individuals, which provided background information including age, gender, nationality and self-motivated n-3 supplement consumption. The aim of this paper was to statistically relate this background information on the subjects to their whole blood FA profile, focusing mainly on the n-3

We present a systematic study on the interaction potential of lamotrigine, with focus on psychoactive drugs. A review of routine serum concentration measurements of lamotrigine performed in our laboratory yielded a total of 1733 serum samples from 829 patients (530 women, 299 men) suitable for statistical analysis. Main results for the whole study population were (median; interquartile range in pa

Heart failure (HF) is associated with high mortality, decreased quality of life, and places a heavy burden on healthcare resources. Numerous HF patients are diagnosed without a conclusive echocardiogram and are lacking appropriate pharmacotherapy. The majority of HF studies in Sweden are based on hospital registries that may not represent the entirety of the HF patient population. This thesis exam

Treating severe dermal disruptions often presents significant challenges. Recent advancements have explored biological cell sprays as a promising treatment, but their success hinges on efficient cell delivery and complete wound coverage. This requires a good spray distribution with a small droplet size, high particle number, and ample surface coverage. The type of nozzle used with the spray device

Therapeutic resistance and recurrence remain core challenges in cancer therapy. How therapy resistance arises is currently not fully understood with tumors surviving via multiple alternative routes. Here, we demonstrate that a subset of cancer cells survives therapeutic stress by entering a transient state characterized by whole-genome doubling. At the onset of the polyploidization program, we ide

This thesis examines housing as a human right and issues of housing inequality in a Swedish context. The aim is to examine discourses on housing, particularly centred on renovation causing rent increases in rental apartments owned by a public housing company in Sweden. The material constitutes of legal documents from two cases in the rent tribunal, one interview with a representative of the Swedis

As the climate changes the risks to agriculture increases which is a threat to food security around the world. One such risk is an increase in rainfall which can lead to decreased crop yields. Sweden today is dependent on other countries for their food supply, however the countries it depends on will suffer more from climate related risks to their agriculture meaning that Sweden's own food pro

Transition metal ions play crucial roles in the structure and function of numerous proteins, contributing to essential biological processes such as catalysis, electron transfer, and oxygen binding. However, accurately modeling the electronic structure and properties of metalloproteins poses significant challenges due to the complex nature of their electronic configurations and strong correlation e

The sPHENIX Time Projection Chamber Outer Tracker (TPOT) is a Micromegas based detector. It is a part of the sPHENIX experiment that aims to facilitate the calibration of the Time Projection Chamber, in particular the correction of the time-averaged and beam-induced distortions of the electron drift. This paper describes the detector mission, setup, construction, installation, commissioning and pe

Based on the Shidi-1 drill core, this paper presents new and highly time resolved carbon isotope data (δ13Ccarb) for the Early Ordovician through Early Silurian of the Yangtze Platform, South China. Five carbon isotopic shifts (C1-C5) through the late Tremadocian to the Katian have been recognized in the Shidi-1 drill core recordings. Together with previously published isotope data, a composite ca

β-d-Galp-(1→3)-d-GalNAc (1) was synthesised from lactose and GalNAc on a mmolar scale by transgalactosylation using β-d-galactosidase from bovine testes. The large proportions of unwanted oligosaccharides in the product mixture were removed by treatment with β-d-galactosidase from E. coli, which left 1, monosaccharides, and a small proportion of trisaccharides. Carbon-Celite chromatography then ga

Structural systems in seismic-prone regions can experience sudden deterioration caused by earthquake-induced ground-motion sequences. In addition, given the prevailing environmental conditions at their site, these systems may undergo gradual deterioration resulting from environment-induced mechanisms. The combined impacts of such phenomena can result in significant structural/non-structural damage