In this paper, we propose a cognitive semantic approach to represent part–whole relations. We base our proposal on the theory of conceptual spaces, focusing on prototypical structures in part–whole relations. Prototypical structures are not accounted for in traditional mereological formalisms. In our account, parts and wholes are represented in distinct conceptual spaces; parts are joined to form

. von Willebrand disease (VWD) is the most common inherited bleeding disorder, but variable severity and several classification types mean that diagnosis is often not straightforward. In many countries, the assays are not readily available and/or are not well standardized. The latest methods and the basis of VWD are discussed here, together with information from the international quality assessmen

BACKGROUND: Palliative care should be provided, irrespective of setting to all patients facing a life-threatening illness and to their families. The situation and needs of older people differ from those of younger people since they often have several co-existing diseases and health complaints. This implies an extensive need for care and for longer periods of palliative care. The main providers of

Studies that have examined the association between alcohol consumption and gastric cancer (GC) risk have been inconsistent. We conducted an investigation of 29 genetic variants in alcohol metabolism loci (alcohol dehydrogenase, ADH1 gene cluster: ADH1A, ADH1B and ADH1C; ADH7 and aldehyde dehydrogenase, ALDH2), alcohol intake and GC risk. We analyzed data from a nested case-control study (364 cases

Relatively little bracing of steel girders can significantly reduce possible risk of buckling failures, before the composite action between steel and concrete occurs. This paper intended both experimentally and numerically, to study the torsional bracing performance of a typical type of scaffoldings commonly used in bridge construction. Minor improvements in the structure of the scaffoldings as we

Background Evaluating the external validity of clinical trials requires knowledge not only of the study population but also of a relevant reference population. The main aim of this study was to present data from a large, contemporary, population-based cohort of patients with colonic cancer. Methods Data on patients diagnosed between 2007 and 2011 were extracted from the Swedish Colon Cancer Regist

In 2D electronic spectroscopy, oscillatory signals have recently received increased attention. The key issue is the origin of such beating-whether it is vibrational or electronic. In analogy to the distinction between rephasing and nonrephasing contributions to 2D spectra, we separate signal components with positive and negative coherence beating frequency via a third Fourier transformation and co

Chronic hyperglycemia leads to pancreatic beta-cell dysfunction characterized by diminished glucose-stimulated insulin secretion (GSIS), but the precise cellular processes involved are largely unknown. Here we show that pancreatic beta-cells chronically exposed to a high glucose level displayed substantially increased amounts of stress fibers compared with beta-cells cultured at a low glucose leve

The internal dosimetry computer program internal dose assessment by computer (IDAC) for calculations of absorbed doses to organs and tissues as well as effective doses to patients from examinations with radiopharmaceuticals has been developed. The new version, IDAC2.0, incorporates the International Commission on Radiation Protection (ICRP)/ICRU computational adult male and female voxel phantoms a

Rate-ratio asymptotic analysis is carried out to elucidate the influence of nitrous oxide on the structure and critical conditions for extinction of nonpremixed methane flames. Steady, axisymmetric, laminar flow of two counterflowing streams toward a stagnation plane is considered. One stream is made up of a mixture of methane and nitrogen. The other stream is a mixture of oxygen, nitrous oxide, a

One of the core areas for research in SLA is the identification and definition of developmental stages in different L2s. For French, Bartning and Schlyter (2004) presented a model of six morphosyntactic stages of development, which was later implemented in the computer program Direkt Profil (Granfeldt et al. 2006). Despite the potential importance of such results, research on developmental stages

This paper introduces and explores the psychological and social factors that both contribute to and inhibit behaviour change vis-a-vis sustainable (tourist) mobility. It is based on papers presented at the Freiburg 2012 workshop. Specifically, it reviews climate change attitudes and perceptions, the psychological benefits of tourism mobilities, addictive elements of mobility and social norming eff

Amyloid beta is generated from the copper- and heparan sulfate (HS)-binding amyloid precursor protein (APP) by proteolytic processing. APP supports S-nitrosylation of the HS-proteoglycan glypican-1 (Gpc-1). In the presence of ascorbate there is NO-catalyzed release of anhydromannose (anMan)-containing oligosaccharides from Gpc-1-SNO. We have investigated whether these oligosaccharides interact wit

In the present paper the thermal fluid-structure-interaction is experimentally and numerically investigated. Therefore, the interaction phenomena is modeled by the Reynolds-averaged Navier-Stokes equations and the nonlinear Fourier heat conduction equation are used for the fluid and the solid phase, respectively. The simulation is performed using a partitioned approach using the finite volume meth

Both organizations and management theory seem obsessed with creativity and 'the new,' but lately, the 'newness' of this so-called 'new' has also been questioned. With this paper, I continue in this critical fashion and point to the peculiar fact that the obsession with the new is accompanied by just as strong a rejection of that which is different. Overcoming this paradox, the paper emphasizes the

Assessment of prognosis after out-of-hospital cardiac arrest (OHCA) is challenging. Cerebral computed tomography (cCT) scans are widely available, but the use in prognostication of comatose OHCA-patients is unclear. We evaluated the prognostic value of cCT in a clinical cohort of OHCA-patients.

The diverse cichlid species flocks of the East African lakes provide a classical example of adaptive radiation. Territorial aggression is thought to influence the evolution of phenotypic diversity in this system. Most vertebrates mount hormonal (androgen, glucocorticoid) responses to a territorial challenge. These hormones, in turn, influence behavior and multiple aspects of physiology and morphol

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) participate in pathological tissue damage. Mitochondrial manganese superoxide dismutase (MnSOD) normally keeps ROS and RNS in check. During development of mangafodipir (MnDPDP) as a magnetic resonance imaging (MRI) contrast agent, it was discovered that MnDPDP and its metabolite manganese pyridoxyl ethyldiamine (MnPLED) possessed SO

Glial cell line-derived neurotrophic factor (GDNF) and its close relative neurturin are currently in clinical trials for neuroprotection in patients with Parkinson disease (PD). However, in animal models of PD, GDNF fails to protect nigral dopamine (DA) neurons against α-synuclein-induced neurodegeneration. Using viral vector delivery of human wild-type α-synuclein to nigral DA neurons in rats, we