Lubricin, a heavily O-glycosylated protein, is essential for boundary lubrication of articular cartilage. Strong surface adherence of lubricin is required given the extreme force it must withstand. Disulfide bound complexes of lubricin and cartilage oligomeric matrix protein (COMP) have recently been identified in arthritic synovial fluid suggesting they may be lost from the cartilage surface in o

Type 2 diabetes (T2D) is a complex polygenic disease influenced by both environmental and genetic factors resulting in impaired insulin release from pancreatic beta cells and insulin resistance in target tissues. The incidence of T2D is escalating and it is projected that over 640 million people will be affected by 2040. Therefore, it is imperative to understand molecular processes that cause T2D

The electromagnetic environment of a tunnel junction can influence significantly the tunneling characteristics. We investigate experimentally a particular environment formed by tunnel junctions and compare the results with a theoretical model. We discuss Single Junction Thermometer and a two junction Coulomb Blockade Thermometer as examples.

Many ships today rely on Global Navigation Satellite Systems (GNSS), for their navigation, where GPS (Global Positioning System) is the most well-known. Unfortunately, the GNSS systems make the ships dependent on external systems, which can be malfunctioning, be jammed or be spoofed. There are today some proposed techniques where, e.g., bottom depth measurements are compared with known maps using

Background The aim of the present study was to examine the outcomes and prognostic factors after surgery with curative intent for distal cholangiocarcinoma during a modern timespan, in a Swedish tertiary referral center. Methods All patients who underwent pancreaticoduodenectomy for distal cholangiocarcinoma between April 2008 and December 2015 were identified. Survival was estimated using the Kap

The paper analyzes dynamic epistemic logic from a topological perspective. The main contribution consists of a framework in which dynamic epistemic logic satisfies the requirements for being a topological dynamical system thus interfacing discrete dynamic logics with continuous mappings of dynamical systems. The setting is based on a notion of logical convergence, demonstratively equivalent with c

A dominant conceptualization of empathy in social work practice and education, provided by Karen Gerdes and Elizabeth Segal, relies heavily on the simulation theory adopted directly from the cognitive neurosciences. The aim was to critically challenge such a view by reporting on some recent empirical findings from the field in which professional social workers were interviewed about their experien

According to the fitting-attitude analysis of value (FA-analysis), to be valuable is to be a fitting object of a pro-attitude. In earlier publications, setting off from this format of analysis, I proposed a modelling of value relations which makes room for incommensurability in value. In this paper, I first recapitulate the value modelling and then move on to suggest adopting a structurally simila

Objectives/Hypothesis: Data from patients registered for myringoplasty during 2002 to 2012 in the Swedish National Quality Registry for Myringoplasty. Study Design: Both conventional myringoplasty and fat-graft techniques were used aimed at healing the tympanic membrane in noninfected ears. Methods: Analysis was performed on data in a national database collected from 32 ear, nose, and throat clini

The interplay between shape anisotropy and directed long-range interactions enables the self-assembly of complex colloidal structures. As a recent highlight, ellipsoidal particles polarized in an external electric field were observed to associate into well-defined tubular structures. In this study, we systematically investigate such directed self-assembly using Monte Carlo simulations of a two-poi

We determine Mg abundances in six Gaia benchmark stars using theoretical one-dimensional (1D) hydrostatic model atmospheres, as well as temporally and spatially averaged three-dimensional (〈3D〉) model atmospheres. The stars cover a range of Teff from 4700 to 6500 K, log g from 1.6 to 4.4 dex, and [Fe H] from -3.0 dex to solar. Spectrum synthesis calculations are performed in local thermodynamic eq

The delivery of immunomodulators directly into the tumor potentially harnesses the existing antigen, tumor-specific infiltrating lymphocytes, and antigen presenting cells. This can confer specificity and generate a potent systemic anti-tumor immune response with lower doses and less toxicity compared to systemic administration, in effect an in situ vaccine. Here, we test this concept using the nov

Improved female control over land is often put forth as a means of raising the productivity of smallholder agriculture, enhancing female bargaining power and raising women's incomes. The article uses some quantitative but primarily qualitative data on access to income and decision making, to analyse gender patterns related to welfare, incomes and control over resources in a context where women's r