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B cell lymphoma and myeloma in murine Gaucher's disease

Multiple myeloma and B cell lymphoma are leading causes of death in Gaucher's disease but the nature of the stimulus driving the often noted clonal expansion of immunoglobulin-secreting B cells and cognate lymphoid malignancy is unknown. We investigated the long-term development of B cell malignancies in an authentic model of non-neuronopathic Gaucher's disease in mice: selective deficiency of -gl

Nanosecond Structured Laser Illumination Planar Imaging for Single-Shot Imaging of Dense Sprays

Recently, a novel laser imaging technique, structured laser illumination planar imaging (SLIPI), has demonstrated great potential for suppressing multiply scattered light in spray imaging. SLIP! uses a laser sheet whose intensity is modulated in the spatial domain. Directly scattered photons keep this structural information; whereas, photons that experienced several scattering events lose this inf

Comorbidities and Mortality in Bipolar Disorder A Swedish National Cohort Study

IMPORTANCE Bipolar disorder is associated with premature mortality, but the specific causes and underlying pathways are unclear. OBJECTIVE To examine the physical health effects of bipolar disorder using outpatient and inpatient data for a national population. DESIGN, SETTING, AND PARTICIPANTS National cohort study of 6 587 036 Swedish adults, including 6618 with bipolar disorder. MAIN OUTCOMES AN

Struvite-based fertilizer and its physical and chemical properties.

This study describes a method to formulate struvite fine powder into pellets that are easy to spread on agricultural land. To evaluate the quality of produced pellets, some chemical and physical properties commonly measured for fertilizers were tested. The findings indicated that the salt index and heavy metal content ofstruvite pellets were significantly lower than those of commercial NPK fertili

Poly(tetrafluorostyrenephosphonic acid) - polysulfone block copolymers and membranes

A series of ionic ABA triblock copolymers having a central polysulfone (PSU) central block and poly(2,3,5,6,-tetrafluorostyrene-4-phosphonic acid) (PTFSPA) outer blocks with different lengths were prepared and studied as electrolyte membranes. PSU with terminal benzyl chloride groups was used as a bifunctional macroinitiator for the formation of poly(2,3,4,5,6-pentafluorostyrene) (PPFS) blocks by

A jawed polychaete fauna from the late Ludlow Kozlowskii event interval in the Prague Basin (Czech Republic)

This paper deals with a diverse fauna of polychaetes possessing jaws (= scolecodonts) from the late Silurian Kopanina Formation of the Prague Basin (Czech Republic). The most common genera are Kettnerites, Oenonites and Pistoprion; the entire collection contains at least 16 genera. This is in stark contrast to the four genera recorded from this region by previous authors. The fauna described shows

Dry-Reagent Double-Monoclonal Assay for Cystatin C

BACKGROUND: Cystatin C is a low molecular weight cysteine proteinase inhibitor whose plasma or serum concentrations have been shown to be better correlated with glomerular filtration rate than serum creatinine concentrations. Routine assays for cystatin C are based on use of polyclonal antibodies and immunoturbidimetric and nephelometric designs. This study aimed to develop a double-monoclonal imm

Validation of a Parental Questionnaire to Identify Atopic Dermatitis in a Population-Based Sample of Children up to 2 Years of Age.

Background: Validated eczema questionnaires have been available for schoolchildren only, but the incidence of atopic dermatitis (AD) is highest during infancy. Objective: To validate a parental questionnaire to identify AD in children up to 2 years of age. Methods: Parents of 476 children answered a written questionnaire prior to an examination by a physician. Sensitivity, specificity, predictive

Role of non-coding RNAs in pancreatic beta-cell development and physiology.

The progression of diabetes is accompanied by increasing demand to the beta-cells to produce and secrete more insulin, requiring complex beta-cell adaptations. Functionally-active and ubiquitous non-coding RNAs (ncRNAs) have the capacity to take part in such adaptations as they have been shown to be key regulatory molecules in various biological processes. In the pancreatic islets, the function of

Imaging apolipoprotein AI in vivo

Coronary disease risk increases inversely with high-density lipoprotein (HDL) level. The measurement of the biodistribution and clearance of HDL in vivo, however, has posed a technical challenge. This study presents an approach to the development of a lipoprotein MRI agent by linking gadolinium methanethiosulfonate (Gd[MTS-ADO3A]) to a selective cysteine mutation in position 55 of apo AI, the majo

Multi-scale Measurement of (Amorphous) Polymer Deformation: Simultaneous X-ray Scattering, Digital Image Correlation and In-situ Loading

This paper presents a method to investigate the behaviour of polymers on different scales during deformation using simultaneously collected synchrotron X-ray scattering, digital image correlation (DIC) and tensile loading. The method is demonstrated through experiments made on specimens of amorphous polycarbonate. Deformation is measured in-situ, simultaneously across different scales from the mac

When More Depletion Offsets the Ego Depletion Effect

The ego depletion effect has been consistently replicated using the typical paradigm that consists of two consecutive tasks. However, striking contradiction exists in studies employing multiple tasks. The aim of the current study is to replicate previous studies following a similar procedure and design in a sample of participants from a non-western cultural background (Chinese), while strictly con

Researchers’ Blogging Practices in Two Epistemic Cultures: The Scholarly Blog as a Situated Genre

This article presents a study of 16 scholarly blogs with the aim to gain an in-depth understanding of what characterizes blogging as part of the scholarly communication. Eight blogs from high energy physics (HEP) and eight from digital history were closely followed. The analysis was made by employing an analytical framework based on genre theory. The results reveal common communicative purposes in

Perceptions of innovativeness among Iranian hotel managers

Despite the undisputed importance of organizational innovation and decades of academic research on the subject, there is surprisingly little agreement on what innovativeness is or how to achieve successful innovation in practice. Furthermore, the difference between the theory and practice is often interpreted in an ad hoc manner, which limits the potential for innovation to provide a competitive a

Serotonergic Neurons Mediate Dyskinesia Side Effects in Parkinson's Patients with Neural Transplants

Troublesome involuntary movements in the absence of dopaminergic medication, so-called off-medication dyskinesias, are a serious adverse effect of fetal neural grafts that hinders the development of cell-based therapies for Parkinson's disease. The mechanisms underlying these dyskinesias are not well understood, and it is not known whether they are the same as in the dyskinesias induced by L-dopa

Equation of State of Colloidal Dispersions.

We present a comparison of experimentally and theoretically determined osmotic pressures for various colloidal dispersions. Experimental data is collected from several different silica and polystyrene dispersions. The theoretical pressure determinations are based on the primitive model combined with the cell model, and the physical quantities are calculated exactly using Monte Carlo simulations in

Concomitant use of warfarin and ticagrelor as an alternative to triple antithrombotic therapy after an acute coronary syndrome.

Treatment with warfarin in combination with clopidogrel has been shown to reduce the incidence of major bleeding as compared to triple antithrombotic therapy (TT; warfarin, clopidogrel and aspirin). However, there are uncertainties regarding the risk for thrombosis since poor-responsiveness to clopidogrel is common. Ticagrelor is a more potent platelet inhibitor, but data supporting concurrent use

Ca/Na Montmorillonite: Structure, Forces and Swelling Properties.

Ca/Na montmorillonite and natural Wyoming bentonite (MX-80) have been studied experimentally and theoretically. For a clay system in equilibrium with pure water, Monte Carlo simulations predict a large swelling when the clay counterions are monovalent, while in presence of divalent counterions a limited swelling is obtained with an aqueous layer between the clay platelets of about 10 A. This latte

Effects of TGF-β signaling in Clear Cell Renal Cell Carcinoma cells.

Clear cell renal cell carcinoma (ccRCC) is by far the most common type of kidney cancer and is characterized by loss of the tumor suppressor gene von Hippel-Lindau (VHL). ccRCC patients with metastatic disease has poor prognosis and today's therapy is insufficient. The cytokine Transforming Growth Factor-β (TGF-β) has been extensively studied in tumor biology and is believed to serve a variety of