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Respiratory infection recurrence and passive smoking in early atherosclerosis in children and adolescents with type 1 diabetes.

BACKGROUND: Optimal glucose control in juvenile type 1 diabetes mellitus is necessary but not sufficient to reduce the burden of cardiovascular events in later life. This emphasizes the importance of searching for other possible risk factors associated with diabetes. We investigated whether recurrent episodes of acute respiratory infections and exposure to tobacco smoke could influence vascular ph

Celiac Disease Revealed in 3% of Swedish 12-year-olds Born During an Epidemic.

OBJECTIVE:: Sweden experienced a marked epidemic of celiac disease between 1984 and 1996 in children younger than 2 years of age, partly explained by changes in infant feeding. The objective of this study was to determine the prevalence of celiac disease in 12-year-olds born during the epidemic (1993), including both symptomatic and screening detected cases. PATIENTS AND METHODS:: All sixth-grade

Noddings's caring ethics theory applied in a paediatric setting.

Since the 1990s, numerous studies on the relationship between parents and their children have been reported on in the literature and implemented as a philosophy of care in most paediatric units. The purpose of this article is to understand the process of nurses' care for children in a paediatric setting by using Noddings's caring ethics theory. Noddings's theory is in part described from a theoret

Natural History of Open-Angle Glaucoma.

OBJECTIVE: This article, based on the Early Manifest Glaucoma Trial (EMGT), provides prospective natural history data on progression of glaucomatous field defects in 3 of the most common glaucoma types. DESIGN: Cohort of EMGT patients randomized to the untreated control group and followed up to the time of progression, when treatment could be initiated. PARTICIPANTS: We evaluated 118 control patie

Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease.

Recent studies in animal models of Parkinson's disease (PD) have provided evidence that dopamine released from spared serotonin afferents can act as a trigger of dyskinetic movements induced by repetitive, low doses of levodopa. Serotonin neurons have the capacity to store and release dopamine synthesized from systemically administered levodopa. However, because of the lack of any autoregulatory f

High-resolution Vuv Spectroscopy Using Pulsed-laser Sources

The resonance spectroscopic techniques - level-crossing, optical double resonance and quantum-beat spectroscopy - have been employed following pulsed laser excitation. The use of pulsed lasers has enabled spectroscopic studies of atomic structures and radiative lifetimes in the UV/VUV spectral region.

Decreased expression of genes involved in oxidative phosphorylation in human pancreatic islets from patients with type 2 diabetes.

OBJECTIVE: Gene expression alterations, especially in target tissues of insulin, have been associated with type 2 diabetes (T2D). Here, we examined if genes involved in oxidative phosphorylation (OXPHOS) show differential gene expression and DNA methylation in pancreatic islets from patients with T2D compared with non-diabetic donors. DESIGN AND METHODS: Gene expression was analyzed in human panc

Innovation in knowledge intensive industries: The nature and geography of knowledge links

Knowledge has become a key source of competitiveness for advanced regions and nations, indicating a transformation of capitalism towards a "knowledge economy". Knowledge intensive sectors in production and in services have a lead in this respect, they can be considered as role models for the future. The innovation process, the mechanisms of knowledge exchange and the respective linkages in those i

Expression of somatostatin receptor subtypes 2 and 4 in human benign prostatic hyperplasia and prostatic cancer.

BACKGROUND: The presence of receptor subtypes for the inhibitory peptide somatostatin in prostatic tissue has been a controversial issue with conflicting reports. To elucidate whether prostatic epithelial cells express mRNA for somatostatin receptor (SSTR) subtype 2 and 4, we have investigated the localization of SSTR2 and SSTR4 transcripts in prostatic tissues by in situ hybridization. METHODS: N

On force control for assembly and deburring of castings

Traditional industrial robots have problems interacting with an uncalibrated, ill-defined environment where part geometry and position may vary. Active force control technology has therefore been suggested as a solution to add the extra sensory dimension needed to handle manufacturing tasks like assembly and deburring. The technology is proposed to give increased flexibility compared to other solu

N1421K mutation in the glycoprotein Ib binding domain impairs ristocetin- and botrocetin-mediated binding of von Willebrand factor to platelets.

von Willebrand disease (VWD) is a common inheritable bleeding disorder caused by deficiency of von Willebrand Factor (VWF), which is involved in platelet adhesion and aggregation. We report a family consisting of three patients with VWD characterized by an apparently normal multimeric pattern, moderately decreased plasma factor VIII (FVIII) and VWF levels, and disproportionately low plasma VWF:RCo

From IT deployment capabilities to competitive advantage: An exploratory study in China

Abstract As more and more companies are deploying, or plan to deploy, information systems, the organizational capabilities to effectively deploy information technologies to support and shape businesses become increasingly important. While many studies have focused on how to acquire state-of-the-art information technologies and on how to effectively utilize implemented information technologies, mor

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent.

Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver damage and is characterized by steatosis. Genetic factors increase risk for progressive NAFLD. A genome-wide association study showed that the rs641738 C>T variant in the locus that contains the membrane bound O-acyltransferase domain-containing 7 gene (MBOAT7, also called LPIAT1) and transmembrane channel-like 4 gene (TMC4) incr

Long-term nicotine exposure causes increased concentrations of trypsinogens and amylase in pancreatic extracts in the rat.

To develop radioimmunoassays (RIAs) for rat trypsinogens 1 and 2 and to investigate the effect of nicotine exposure on concentration and production of pancreatic zymogens in the rat. METHODS: Male Sprague-Dawley rats were supplied with either normal or nicotine-containing (0.77 mM) water for 28 days and were then killed. Rabbit antibodies for the activation peptides of trypsinogens 1 and 2 were ob