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Background: Deposition of tau aggregates is a pathological hallmark of Alzheimer's disease that is closely linked both spatially and temporally to emergence of neurodegeneration and manifestation of clinical symptoms. There is an urgent need for accurate PET, CSF, and plasma biomarkers of tau pathology to improve the diagnostic process in clinical practice and the selection of participants and mon
Traffic safety is high on the agenda of European governments. Yet, countries including Germany maintain policies that are commonly identified as increasing traffic risks, such as speed limits set too high or trends of greater car motorization and mass. To better understand some of the interrelationships of driver characteristics and car segments, this paper identifies different groups of drivers,
In vivo human diffusion MRI is by default performed using single-shot EPI with greater than 50-ms echo times and associated signal loss from transverse relaxation. The individual benefits of the current trends of increasing B0 to boost SNR and employing more advanced signal preparation schemes to improve the specificity for selected microstructural properties eventually may be cancelled by increas
Path integration is a computational strategy that allows an animal to maintain an internal estimate of its position relative to a point of origin. Many species use path integration to navigate back to specific locations, typically their homes, after lengthy and convoluted excursions. Hymenopteran insects are impressive path integrators, directly returning to their hives after hundreds of meters of
Pediatric complex regional pain syndrome (pCRPS) is a rare, painful state that often occurs as a complication following physical trauma. Diagnosis and treatment require specialist expertise in a multidisciplinary setting. Treatment is focused on pain reduction and improvement in function, which differs from the treatment of adult CRPS. We performed a cross-sectional survey with the aim of identify
This article explores the burgeoning Nepalese hip-hop scene – commonly known as nep-hop – as a discursive intervention in the post-war politics of Nepal. Its core argument is that nep-hop oftentimes demonstrates an ethos of peacebuilding through popular culture. Indeed, many songs explicitly criticize violence, war, and the political leaders who recently brought the nation to a civil war. Yet, thi
The academic debates on post-war memorialisation and everyday peace tend to appear in relative isolation from one another. Yet, there is arguably much to gain from integrating them, by exploring how – and to what effect – post-war monuments are incorporated into everyday life. To this end, this article studies the everyday interactions that residents of Beni Bazaar, Nepal, have developed in relati
In the seminal cases C-156/21 and C-157/21 (‘Budget Conditionality Cases’) the Court of Justice of the European Union demonstrated a shift in the perception of the operational functionality of foundational values of the EU, establishing that the rule of law is a founding value of the Union which represents a legal norm and imposes an obligation on the Member States to comply with its constituent e
We discuss remarkable constructions in Icelandic that have the distributive pronoun hvor ‘each’ in common: the reciprocal construction hvor annar ‘each other’, and the distributive construction hvor sinn ‘each their’, which also comes in a sinn hvor ‘their each’ version. We provide the first detailed description of these constructions, in particular their case and word order properties, which rais
For regions that are deeply integrated into the global economy, the question of how to remain competitive and resilient in times of uncertainty is a key concern. While strategic coupling is a useful concept for understanding local-global economic dynamics, the idea that a region can simultaneously couple into multiple production networks organised at different spatial scales and that regional acto
Transparency in artificial intelligence (AI) can mean many things, but at the same time, it is currently a central focus for both scientific and regulatory attention. We seek to critically unpack this conceptual vagueness. This is particularly called for given recent focus on transparency in much of AI policy. To this end, we construct our analysis of AI Transparency into four facets. Firstly, (1)
Diffusion MRI (dMRI) sensitizes the MR signal to the diffusion of water molecules at the microscopic level and thereby non-invasively probes tissue microstructure. This is relevant when determining biological properties of tissues, for example, cancer type and its malignancy. The problem is, however, that dMRI lacks sensitivity and specificity to distinct microstructural features because an image
Non-medical prescription use of opioids (NMPUO) is a public health concern worldwide. Recently, tramadol misuse is increasing, but the systematic research of misuse of this specific opioid is limited. This study set out to assess the relationship between tramadol use and completion of treatment for substance use among adolescents and adults ≤ 25 years in an outpatient clinical setting. A retrospec
