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Long-term effects of hyperbaric oxygen therapy on visual acuity and retinopathy

Hyperbaric oxygen (HBO2) therapy is an adjunct treatment for diabetic foot ulcers. Since plausible mechanisms of action for this treatment include increased angiogenesis and high tissue oxygen concentrations, concerns about deterioration of retinopathy have been raised. The aim of this study was to evaluate the effects of HBO2 on visual acuity (VA) and retinopathy in patients with chronic diabetic

Toeplitz-Based Underwater Acoustic Channel Blind Deconvolution

In this paper, we propose a blind channel deconvolution method based on the Least Absolute Shrinkage and Selection Operator (LASSO). Using a Toeplitz structured formulation of the received signal, we form an iterative blind deconvolution scheme, alternatively estimating the underwater impulse response, and alternatively the transmitted waveform. The resulting optimizations are convex, and we formu

The tangled past of eukaryotic enzymes involved in anaerobic metabolism

There is little doubt that genes can spread across unrelated prokaryotes, eukaryotes and even between these domains. It is expected that organisms inhabiting a common niche may exchange their genes even more often due to their physical proximity and similar demands. One such niche is anaerobic or microaerophilic environments in some sediments and intestines of animals. Indeed, enzymes advantageous

Identification of Inflammatory and Disease-Associated Plasma Proteins that Associate with Intake of Added Sugar and Sugar-Sweetened Beverages and Their Role in Type 2 Diabetes Risk

It has been suggested that high intake of added sugar and sugar-sweetened beverages (SSBs) increase the level of circulating inflammatory proteins and that chronic inflammation plays a role in type 2 diabetes (T2D) development. We aim to examine how added sugar and SSB intake associate with 136 measured plasma proteins and C-reactive protein (CRP) in the Malmö Diet and Cancer-Cardiovascular Cohort

Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes

Metformin is the first-line pharmacotherapy for managing type 2 diabetes (T2D). However, many patients with T2D do not respond to or tolerate metformin well. Currently, there are no phenotypes that successfully predict glycemic response to, or tolerance of, metformin. We explored whether blood-based epigenetic markers could discriminate metformin response and tolerance by analyzing genome-wide DNA

Förbudet mot rättsmissbruk i EU-rätten : En förändrad avvägning mellan rättssäkerhet och rättvisa i den svenska skatterätten

This dissertation concerns a legal development that is currently taking place in Sweden due to its membership in the European Union (EU). It analyses the impact of the EU legal principle on abuse of law (the abuse principle). This principle has been developed gradually under long time in EU law and clarifying rulings from the Court of Justice of the European Union (CJEU) on the general nature of t

Silver nanoparticles alter cell viability ex vivo and in vitro and induce proinflammatory effects in human lung fibroblasts

Silver nanoparticles (AgNPs) are commonly used in commercial and medical applications. However, AgNPs may induce toxicity, extracellular matrix (ECM) changes and inflammatory responses. Fibroblasts are key players in remodeling processes and major producers of the ECM. The aims of this study were to explore the effect of AgNPs on cell viability, both ex vivo in murine precision cut lung slices (PC

Literary Remediations of Contemporary Television Series : From The Familiar to Storytel Originals

In order to investigate the relation between literature and television, one must consider how the influence goes both ways. The chapter accordingly investigates how contemporary literature reflects on, imitates and remediates modern television series. Drawing on theoretical approaches by Jim Collins and Jason Mittell, I analyse Mark Z. Danielewski’s serial novel The Familiar, which mimics and invo

Video analysis of pedestrian movement (VAPM) under different lighting conditions—method exploration

When daylight hours are limited, pedestrians are dependent on appropriate outdoor lighting. Although new city lighting applications must consider both energy usage and pedestrian responses, current methods used to capture pedestrian walking behaviour during dark conditions in real settings are limited. This study reports on the development and evaluation of a video-based method that analyses pedes

Vegetation dynamics and Fire History in Färnebofjärden National Park, Central Sweden

Palaeoecological studies can identify past trends in vegetation communities and processes over long time scales. Pollen, plant macrofossils and charcoalanalyses are used to reconstruct vegetation over the last 6400 years and provide information about former human impact and disturbance regimesin Färnebofjärden National Park, Central Sweden. Three specific conservation planning topics were addresse

Complex evolutionary history of translation elongation factor 2 and diphthamide biosynthesis in archaea and parabasalids

Diphthamide is a modified histidine residue which is uniquely present in archaeal and eukaryotic elongation factor 2 (EF-2), an essential GTPase responsible for catalyzing the coordinated translocation of tRNA andmRNA through the ribosome. In part due to the roleofdiphthamide inmaintaining translational fidelity, itwas previously assumed that diphthamide biosynthesis genes (dph) are conserved acro