In order to study interinstitutional reproducibility of flow cytometric DNA-analysis (DNA-FCM), frozen pieces from 30 consecutive breast carcinomas were analysed by 5 laboratories. Different instruments, preparation and DNA staining methods were used. A concordance in DNA-ploidy status was obtained in 26 of the 30 tumours. The discrepancy can mainly be explained by intratumoural DNA-heterogeneity

Background Smoking is known to cause chronic inflammatory changes in the bronchi and to contribute to airway hyper-reactivity, such as in bronchial asthma. To study the effect of smoking on the endothelin system in rat airways, bronchial segments were exposed to DMSO-soluble smoking particles (DSP) from cigarette smoke, to nicotine and to DMSO, respectively. Methods Isolated rat bronchial segment

The thesis deals with scheduler and controller co-design for real-time control systems. The overall goal is higher resource utilization and better control performance. One goal is to minimize the performance loss due to jitter and control delays. Another goal is to relax the nominal requirements on hard deadlines and fixed worst-case execution times. A third goal is to provide a co-simulation envi

The effects of 2,3-butanedione monoxime (BDM) on intracellular Ca2+ transient and cross-bridge function were studied in frog single fibres from the anterior tibialis muscle of Rana temporaria (sarcomere length, 2.2 m; temperature, 24 C). The fluorescent dye fluo-3 was used to monitor the intracellular free calcium concentration ([Ca2+i) during isometric contractions. BDM (15 m M) reduced the ampli

The unstable neutron-deficient Sn-108 isotope has been studied in inverse kinematics by intermediate-energy Coulomb excitation using the RISING/FRS experimental setup at GSI. This is the highest Z nucleus studied so far with this method. Its reduced transition probability B (E2;0(g.s.)(+)-> 2(1)(+)) has been measured for the first time. The extracted B(E2) value of 0.230(57)e(2) b(2) has been dete

Denna rapport i Kyrkohistorisk årsskrift, som jag sedan 2001 redigerar, redovisar LUKA:s utvidgade verksamhet med årliga arrangemang som LUKA-dagen i mars och Arkivens dag i november, skriftutgivning (Bibliotheca Historico-Ecclesiastica Lundensis samt Meddelanden från Kyrkohistoriska arkivet i Lund. Ny följd), nya frågelistor till alla Svenska kyrkans församlingar, till församlingarna i vissa stif

Inhaled corticosteroid (ICS) therapy such as fluticasone propionate (FP) is effective in moderate-to-severe asthma, but for patients on ICS who still experience symptoms, treatment guidelines recommend either increasing the dose of ICS or adding a long-acting beta2-agonist such as salmeterol or formoterol. Several studies have now shown that adding salmeterol provides greater clinical benefit than

Cold feet comprise problems for lots of people. Various methods can be used for determination of the thermal properties of footwear. A method using a thermal foot model allows the study of the insulation under different conditions. The paper describes the combined effect of walking and sweating on thermal insulation. Walking and sweating simulation on the foot model reduced the total insulation up

Objective: The aims of the present study were to evaluate the role of the gap junction protein beta-2 gene (GJB2), encoding connexin 26 (Cx26), in children with moderate to profound prelingual nonsyndromic sensorineural hearing impairment (HI) and to investigate the carrier frequencies of the GJB2 gene mutations in a control population in Northern Finland. Methods: Mutation analysis was performed

The introduction of nasal glucocorticosteroids, 30 years ago, has been the most important therapeutic progress in rhinitis management since the introduction of the first generation of antihistamines. Our knowledge of the mode of action of glucocorticosteroids in the nose has improved as the airway mucous membrane of the nose is easily accessible for investigation. However, the exact mechanism behi

Aim: Palivizumab (Synagis(R)(R)) was registered in Sweden in 1999 for prophylaxis against respiratory syncytial virus (RSV) in premature infants. The high costs and the limited knowledge of the efficacy of this substance have led to debate about how and when it should be used. National guidelines for the use of palivizumab in Sweden were constructed in the year 2000. The aim of this study was to e

This paper reviews decision support methodologies that can be applied to treatment plants. Case studies of decision support systems (DSS) that have been developed and used or trialled are presented below. These include rule-based systems and systems based on digraphs of cause-and-effect relationships. Detection examples on real plant data are presented, in one case using direct measurements and si

Both DNA ploidy and S-phase ploidy are promising prognostic factors for node-negative breast cancer patients. Based largely on the analysis of one large study, much of the reported problems with these factors have been caused by some unappreciated complexities in categorizing DNA ploidy into low- and high-risk groups and the lack of some necessary adjustments to eliminate unwanted correlations bet