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Brain and cellular alterations caused by CYP27A1 deficiency in mouse and human models

Förändringar i hjärnan vid avsaknad av CYP27A1 CYP27A1 är en gen vars färdiga protein är involverat i nedbrytning av kolesterol och gallsyrasyntes. Avsaknad av CYP27A1 eller produktion av en dysfunktionell variant av proteinet i människor resulterar i sjukdomen Cerebrotendinös xantomatos (CTX). CTX är en sjukdom som karaktäriseras av grumling av ögats lins, lipidinlagringar i form av knutor i senCYP27A1 is an important enzyme in cholesterol catabolism and bile acid biosynthesis. Deficiency of this enzyme in human leads to the disease Cerebrotendinous xanthomatosis (CTX), which is a recessively inherited lipid storage disorder characterized by symptoms such as cataracts, tendon xanthomas and progressive neurological syndrome. The underlying cause for the neurological symptoms is not well u

Fuktbetingade rörelser och sprickbildning i fibercementskivor

På senare tid har det påträffats olika typer av skador på fibercementskivor monterade i fasader som har varit svåra att härleda till en specifik orsak. Den främsta skadan som uppkommit är sprickbildning men det har även påträffats andra defekter så som utbuktande skivor. Dessa skador har i flera fall härletts till handhavandefel vid montage men fukt-och temperaturbetingade rörelser tros även vara Recently, various types of damages have been found on fibre cement boards mounted in facades which have been difficult to trace to a specific cause. The main damage that has occurred is cracking but other defects have also been found, such as bulging boards. These damages have in several cases been attributed to handling errors during assembly, but moisture and temperature-related movements are al

Development of a controller to switch between relative and absolute path for target vehicles in simulation scenarios

Simulating vehicle scenarios for autonomous cars saves both time and money compared to physical testing. For this to work efficiently a sophisticated simulation software is often needed. Esmini is an open-source, lightweight vehicle simulator that can handle advanced traffic scenarios. When designing scenarios to be used for testing autonomous vehicles, it is often beneficial to set up relative ve

Ghost target classification using scene models in radar

In surveillance contexts, radars can be used to monitor an area, detecting and tracking moving objects inside it. Monitored areas in urban environments often contain many surfaces that reflect radar waves, which can have the undesired consequence of a single object producing multiple tracks due to multipath propagation effects. This thesis considers a method of identifying if a track is produced b

Indoor Blimp Control

The purpose of this thesis is to model and develop a control law that lets an unmanned aerial vehicle of blimp type fly autonomously in three-dimensional space. There are several uses of the blimp type UAV including, but not limited to, cargo transportation and surveillance. The work done throughout the thesis includes optimization of actuator placements, modelling the blimp and simulating the pro

A new, fast, and efficient automatic tuner for the ABB AC 800M family of controllers

The most common controller in the process industry today is the PID controller due to its simple structure. A regular factory may have thousands of different PID controllers in use where each of them has to be tuned to work satisfactory. Doing this manually can become both a difficult and time consuming task where some knowledge for each process is required. Therefore, it is highly beneficial to h

Artister utan publik : en kvalitativ studie om två artisters övergång till digitala arbetssätt under coronapandemin 2020-2021

The purpose of this study has been to examine in which ways musical artists and entertainers have been working with digital media and intermedial relations during the corona pandemic in the years 2020-2021. Using qualitative methods, this paper aims to create a deeper understanding of digital working strategies and the benefits that can be found with these in comparison with more traditional non-d

Private Regulatory Governance and Sustainable Development: Is there a connection? Mapping linkages of Voluntary Sustainability Standards (VSS) and Sustainable Development Goals (SDGs)

Voluntary Sustainability Standards (VSS) and the Sustainable Development Goals (SDGs) share similar objectives. VSS are being increasingly used because of their claims to address sustainability issues at the production stage, such as greenhouse gas emissions in production, biodiversity conservation, labor rights, worker’s wages, local pollution and good corporate governance. These issues are also

What Makes a Conversation Difficult?: Investigating the Role of Content and Interpersonal Relationships in Managerial Conversations

Dealing with difficult conversations is recognised as being one of the most challenging aspects of the managerial role. Scholarly research within this field is primarily normative in its nature where difficult conversations are still poorly understood from managers’ point of view. This thesis aimed to explore and analyse how middle managers perceive difficult one-on-one conversations in terms of t

Energy-efficient HVAC solution-sets for low-energy apartment buildings in Nordic climates - An analysis of an affordable housing project

To meet the aims of the Paris climate agreement, it is necessary to reduce energy use in buildings. Efficient HVAC systems are a critical part in achieving a low delivered energy use. However, there is a lack of comparative information of the best HVAC systems for apartment buildings, which represent an increasing share of newly built floor area in the Nordic countries. Elements of HVAC systems we

Lucas and Penrose vs. Computationalism: A Refutation of the Gödel-arguments

John Lucas and Roger Penrose attempted to refute Computationalism, the theory that the human mind is a computational system. They did so by utilizing meta-mathematical proofs by Kurt Gödel. I will explore various objections made against the attempt and discover that it relies on two uncertain premises – human consistency and proof for the consistency of a formal system. Revisions of the argument a

Integrating Ground Source Heat Pumps into Elderly Homes as Energy-efficient Heating and Cooling Solution - A Swedish Case Study

Energy efficiency and environmental questions have gained increased attention over the last decade. In combination with global warming and increasing cooling demands, the Swedish market for combined heating and cooling solutions such as ground source heat pumps expands. As it currently stands, the multi-family building market is highly dominated by district heating, while the market share of combi

Is Externalism Compatible with the KK-thesis?

In this paper I discuss the compatibility of externalism about epistemic justification with the well-known KK-thesis in epistemic logic. A weaker form of the KK-thesis (if one knows, one is also in a position to know that one knows) is first defended against Williamson's anti-luminosity arguments. Given some base assumptions about the nature of human beings and states of knowing, it is argued

Gruppdynamik inom projekt i byggbranschen

Titel: Gruppdynamik inom projekt i byggbranschen Författare: Amanda Turesson & Dahlia Elfadil Handledare: Radhlinah Aulin Examinator: Anne Landin Syfte & Mål: Examensarbetets syfte är att undersöka vilken roll gruppdynamik spelar i projekt inom byggbranschen för att säkerställa ett framgångsrikt projekt . Målet med studien är att sammanfatta ifall Myers Briggs Type Indicator och TuckmaTitle: Group dynamics in projects in the construction industry Authors: Amanda Turesson & Dahlia Elfadil Supervisor: Radhlinah Aulin Examiner: Anne Landin Aim & Goal: The aim of the degree project is to investigate the role group dynamics occupies in projects in the construction industry to ensure a successful project. The goal of the study is to summarize if Myers Briggs Type Indicato

Den verkställande direktörens interna skadeståndsansvar - En jämförelse mellan Sverige och Tyskland

Svenskt företagande har historiskt haft en stark ekonomisk koppling till Tyskland. Den tyska marknaden ses ofta som en attraktiv plattform för svenska företag att etablera sig på och en möjlighet till expansion av bolagets verksamhet. Vid en etablering i Tyskland väljer många svenska aktiebolag att använda sig av bolagsformen Gesellschaft mit beschränkter Haftung, som också är den mest frekvent anSwedish entrepreneurship has historically had a strong economic connection to Germany. The German market is often seen as an attractive platform for Swedish companies to establish themselves on and an opportunity for expansion of the company's operations. When establishing in Germany, many Swedish limited companies choose to use the company form “Gesellschaft mit beschränkter Haftung", wh

More than Rain - A modular rainwater harvesting solution.

This project documentation presents an overview of the design process of the master thesis of Elisabeth Langer and Lisa Laugs at Lund University, School of Industrial Design. The topic of the master thesis was rainwater harvesting, which was first explored through extensive research and analysis. This topic is highly relevant as several aspects such as population growth, urbanisation, and climate

Bevare mig väl! : Om användningen av det okatalogiserade trycket på Lunds universitetsbibliotek

Deliver us from evil! : A study of the use of the uncatalogued small print and ephemera at the Lund University Library. Since 1698 everything printed in Sweden has been delivered to, kept, and made accessible at, the Lund University Library. A considerable part of the material is arranged according to the principle of provenance in a collection with an annual growth of approximately 150 shelfmet

The Impact of Gamification on Motivation to Learn: A study on Using Gamification to Increase Intrinsic Motivation and the Interaction with Personality

Gamification is a concept which can be used to enhance performance and motivation to learn with the help of game design. The present study aims to investigate the effects of gamification on performance, intrinsic motivation, amotivation, as well as exploring the interactions with personality traits. In two separate studies using a randomized experimental design gamification defined by narrative, a

Designing a New Warehouse to Improve Space Utilization and Handling Efficiency: A Case Study of a Production Warehouse

Title: Designing a new warehouse to improve space utilization and handling efficiency: A case study of a production warehouse Authors: Emil Niklasson, Erik Ramström Supervisor: Joakim Kembro, Department of Industrial Management and Logistics, Faculty of Engineering, Lund University Problem description: The focus on warehousing has grown in the industry during the 21st century to increase the compe