The efficiency approach of moving towardssustainable consumption throughmainlytechnological solutions, which dominatesenvironmental policymaking, has overallfailed to reduce the adverse environmental impacts caused by unsustainable consumption patterns. Increasingly, it is recognized that efficiency needs to be coupled with sufficiency, which aims to reduce the absolute levels of consumption. Whil

BACKGROUND: Methods to quantify and evaluate function are important for development of specific rehabilitation interventions. This study aimed to evaluate functional movement compensation in individuals with hip osteoarthritis performing the five times sit-to-stand test and change following total hip arthroplasty. To this end, trajectories of the body's center of mass in the medial-lateral and ant

Recycling is an important area to improve to reduce negative impact on the environment. With increased material recovery, less virgin materials are needed to provide the same benefits for the society. Aluminium is an important metal in the efforts to reduce negative climate impact. Demand for wrought aluminium will heavily increase with electrification of vehicles. However, with today’s recycling,

Glioblastoma has remained the deadliest primary brain tumor while its current therapy offers only modest survival prolongation. Immunotherapy has failed to record notable benefits in routine glioblastoma treatment. Conventionally, immunotherapy relies on T cells as tumor-killing agents; however, T cells are outnumbered by macrophages in glioblastoma microenvironment. In this study, we explore the

BACKGROUND: Nearly a quarter of patients with locally advanced (T4 stage) or perforated colon cancer are at risk of developing peritoneal metastases, often without curative treatment options. We aimed to determine the efficacy of adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with locally advanced colon cancer.METHODS: This multicentre, open-label trial was done in nine hos

In 1969, a government report concluded that there was a need for closer contact between the citizens and Swedish government agencies. Television, at this time still considered a new medium, was highlighted in the report as a valuable form of mass communication with great yet unfulfilled promise as a disseminator of government information. A heated debate about the role and function of government i

Although progress has been made to improve access to sexual and reproductive health services globally in the past two decades, in many low-income countries, improvements have been slow. Discrimination against vulnerable groups and failure to address health inequities openly and comprehensively play a role in this stagnation. Healthcare practitioners are important actors who, often alone, decide wh

Background: Accumulating data support the role of flow cytometry (FCM) in diagnostic work-up of myelodysplastic syndromes (MDS). Changes in erythropoiesis are less documented than in granulopoiesis. However, most studies were performed on bone marrow samples (BMSs) after red blood cell lysis. We have established a FCM protocol for erythropoiesis, following a no-lysis approach and live gate acquisi

The Klotho (KL) gene is involved in phosphate homeostasis. Polymorphisms in this gene have been reported to be associated with the risk of cardiovascular disease. Here we used computational tools to predict the damage-associated single nucleotide polymorphisms (SNPs) in the human KL gene. We further investigated the association of SNPs in the KL gene and mortality in the Swedish multicenter prospe

Animal models of Parkinson's disease (PD) are essential to investigate pathogenic pathways at the whole-organism level. Moreover, they are necessary for a preclinical investigation of potential new therapies. Different pathological features of PD can be induced in a variety of invertebrate and vertebrate species using toxins, drugs, or genetic perturbations. Each model has a particular utility and

Potassium and chlorine chemistry at high temperature is of great importance in biomass utilization through thermal conversion. In well-defined hot environments, we performed quantitative measurements of main potassium species, i.e., potassium hydroxide (KOH), potassium chloride (KCl) and K atoms, and the important radical OH. The concentrations of KOH, KCl and OH radicals were measured through a n

This article shows the importance in human rights law of the right to leave any country, particularly in the light of increasing efforts by European countries of destination to prevent departures, and to contain movement by enrolling countries of origin and transit to act as gatekeepers. The article highlights the autonomous nature of the right and clarifies the challenges in triggering its applic

The links between β-amyloid (Aβ) and tau in Alzheimer's disease are unclear. Cognitively unimpaired persons with signs of Aβ pathology had increased cerebrospinal fluid (CSF) phosphorylated tau (P-tau181 and P-tau217) and total-tau (T-tau), which increased over time, despite no detection of insoluble tau aggregates [normal Tau positron emission tomography (PET)]. CSF P-tau and T-tau started to inc

BACKGROUND: Compared to the general population, patients with alcohol and drug addiction have an increased risk of additional hazardous lifestyles and suffer from more chronic diseases, adding to their already significantly higher morbidity and mortality. The objective of this study was to test the efficacy of the Very Integrated Program (VIP) on treatment and health outcomes for patients diagnose

Aim: Climate change impacts forest functioning and services through two inter-related effects. First, it impacts tree growth, with effects, for example, on biomass production. Second, climate change also reshuffles community composition, with further effects on forest functioning. However, the relative importance of these two effects has rarely been studied. Here, we developed a new modelling appr

We present calculations on the atomic delay in photoionzation obtained with different combinations of linearly and circularly polarized light, and show how a tensor operator approach can be used to readily obtain results for any combination from a single calculation of the radial integrals. We find that for certain choices of polarization and detection geometry a single time-delay measurement is e

According to Zagaria et al. (2020), evolutionary psychology may be the meta-theory that is needed if psychological science is to enter a paradigmatic stage. Other writers have suggested that what is needed is a person-oriented approach, which focuses on the person as a complex system that needs to be studied (1) as a whole (holism), (2) as an intentional agent in interaction with its environment (

The potential role of introgression in evolution has gained increased interest in recent years. Although some fascinating examples have been reported, more information is needed to generalize the importance of hybridization and introgression for adaptive divergence. As limited data exist on haploid dominant species, we analyzed genomes of three subspecies of the liverwort Marchantia polymorpha. We