We have investigated the effect of deposition temperature on supported lipid bilayer formation via vesicle fusion. By using several complementary surface-sensitive techniques, we demonstrate that despite contradicting literature on the subject, high-quality bilayers can be formed below the main phase-transition temperature of the lipid. We have carefully studied the formation mechanism of supporte

Blogs offer a space where engineers can engage with public audiences about engineering topics, challenging and surpassing a deficit model of science communication. Communication that is adapted for a broad audience, discusses topics that are socially relevant, and facilitates participation and dialogue is more likely to be engaging. We examined 14 top engineering blogs to see how engineers present

We appraised the methodology, execution and quality of the five published meta-analyses that are based on the five randomized controlled trials (RCTs) which compared cardiotocography (CTG) +ST analysis to CTG. The meta-analyses contained errors, either created de novo in handling of original data, or from a failure to recognize essential differences among the RCTs, particularly in their inclusion

Background: Previous studies of the natural history of alpha-1-antitrypsin (AAT) deficiency are mostly based on highly selected patients. The aim of this study was to analyse the mortality of PiZZ individuals. Methods: Data from 1339 adult PiZZ individuals from the Swedish National AAT Deficiency Registry, followed from 1991 to 2008, were analysed. Forty-three percent of these individuals were ide

The opacity of the Earth to incident ultrahigh energy neutrinos is directly connected with the behavior of the neutrino-nucleon (sigma(nu N)) cross sections in a kinematic range utterly unexplored. In this work we investigate how the uncertainties in sigma(nu N) due the different QCD dynamic models modify the neutrino absorption while they travel across the Earth. In particular, we compare the pre

Background: Although post-stroke depression is widely recognized, less is known about depressive symptoms in the acute stage of stroke and especially in young stroke patients. We thus investigated depressive symptoms and their determinants in such a cohort. Methods:The Stroke in Young Fabry Patients study (sifap1) prospectively recruited a large multinational European cohort (n = 5,023) of patient

Aims: During recent years, two strategies of incretin-based therapy [glucagon-like peptide-1 (GLP-1) receptor agonism and dipeptidyl peptidase-4 (DPP-4) inhibition] have entered the market for pharmacological management of type 2 diabetes. A main indication for this therapy is as add-on to on-going metformin therapy in subjects with type 2 diabetes who have insufficient glycaemic control with metf

Despite a lack of scientific evidence, oxygen has long been a part of standard treatment for patients with acute myocardial infarction (AMI). However, several studies suggest that oxygen therapy may have negative cardiovascular effects. We here describe a randomized controlled trial, i.e. Supplemental Oxygen in Catheterized Coronary Emergency Reperfusion (SOCCER), aiming to evaluate the effect of

The European Landscape Convention encourages everyone to be part of the management and perception of the landscape. In Swedish forestry today, however, it is experts in biodiversity who are responsible for the management policies used when planning tree retention as a biodiversity conservation strategy. This gives the forest a certain structure, but it is uncertain whether this structure is felt t

We consider the problem of reliable communication over multiple-access channels (MAC) where the channel is driven by an independent and identically distributed state process and the encoders and the decoder are provided with various degrees of asymmetric (noisy or partial) channel state information (CSI). Namely, we provide a single letter characterization for the capacity region when the encoders

Saccharomyces cerevisiae lacks the ability to ferment the pentose sugar xylose that is the second most abundant sugar in nature. Therefore two different xylose catabolic pathways have been heterologously expressed in S. cerevisiae. Whereas the xylose reductase (XR)-xylitol dehydrogenase (XDH) pathway leads to the production of the by-product xylitol, the xylose isomerase (XI) pathway results in si

Despite the ban by the European Union, anabolic steroids might still be illicitly employed in bovine meat production. The surveillance of misuse of such potentially harmful molecules is necessary to guarantee consumers' health. Analytical methods for drug residue control are based on LC-MS/MS, but their efficacy can be hindered due to undetectable residual concentrations as a result of low-dosage

To explore coping with the perceived psychosocial consequences of a false-positive screening mammography.

Abstract Objective. The postprandial acid pocket is suggested to be an important factor in the pathogenesis of gastroesophageal reflux disease (GERD) as it according to the theory extends into the distal esophagus. The aim of this study was to test the hypothesis that the acid pocket transverses the squamocolumnar junction (SCJ) and exposes the most distal esophagus to gastric acid for extended pe

In 1919 the now largely forgotten popular novelist E.M. Hull sparked a decade of infatuation with the ‘desert romance’ on the publication of her first book, The sheik. The obsession with the genre, fuelled by the release of Melford's 1921 film adaptation of the book, saw women swooning in the aisles at ‘screen god’ Rudolph Valentino's starring role. My aim here is to broaden the focus on Hull away

Coherent dynamics in bacterial reaction centres were studied by electronic 2D spectroscopy at 80 K temperature. Polarization measurements together with Fourier analysis allowed assignment of observed population time beatings at different frequencies to the coherences of electronic and vibrational character.

Psychiatric symptoms such as depression and anxiety are important clinical features of Huntingtons disease (HD). However, the underlying neurobiological substrate for the psychiatric features is not fully understood. In order to explore the biological origin of depression and anxiety in HD, we used a mouse model that expresses the human full-length mutant huntingtin, the BACHD mouse. We found that

Molecular dynamics (MD) simulations give atomically detailed information on structure and dynamics in amphiphilic bilayer systems on timescales up to about 1 μs. The reorientational dynamics of the C-H bonds is conventionally verified by measurements of (13)C or (2)H nuclear magnetic resonance (NMR) longitudinal relaxation rates R1, which are more sensitive to motional processes with correlation t