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Stroke is a leading cause of disability and currently lacks effective therapy enabling long-term functional recovery. Ischemic brain injury causes local inflammation, which involves both activated resident microglia and infiltrating immune cells, including monocytes. Monocyte-derived macrophages (MDMs) exhibit a high degree of functional plasticity. Here, we determined the role of MDMs in longterm

We demonstrate that an undamped few-body precursor of the Higgs mode can be investigated in a harmonically trapped Fermi gas. Using exact diagonalization, the lowest monopole mode frequency is shown to depend nonmonotonically on the interaction strength, having a minimum in a crossover region. The minimum deepens with increasing particle number, reflecting that the mode is the few-body analogue of

The glycocalyx is a carbohydrate-rich layer that lines the luminal side of the vascular endothelium. Its soluble components exist in a dynamic equilibrium with the bloodstream and play an important role in maintaining endothelial layer integrity. However, the glycocalyx can be easily damaged and is extremely vulnerable to insults from a variety of sources, including inflammation, trauma, haemorrha

Purpose: To investigate if plasma cytokine concentrations predict a beneficial response to corticosteroid treatment in septic shock patients. Methods: A cohort of septic shock patients in whom a panel of 39 cytokines had been measured at baseline (n = 363) was included. Patients who received corticosteroids were propensity score matched to non-corticosteroid-treated patients. An optimal threshold

Hematopoietic stem cells (HSCs) compose a rare population of undifferentiated cells, residing in the bone marrow of adult individuals, ensuring life-long maintenance and replenishment of the blood system. This fantastic achievement is possible owing to two special characteristics of the HSCs: their ability to make copies of themselves (self-renew), and their capacity to differentiate to all lineag

Sport diplomacy provides a challenging example of how diplomaticpractice is changing in light of a proliferation of actors,agendas, and modes of communication. This context hasinspired greater interest in techniques for managing the participationof others in the pursuit of desired outcomes, such asdebates surrounding multi-stakeholder diplomacy, publicdiplomacy, and soft power. However, these deba

Det första skedet när ett byggnadsverk ska uppföras är det konceptuella designskedet, det är här de första besluten om utformningen av byggnadsverket görs. I det traditionella arbetsflödet utformas byggnadsverket först i ett ritprogram, sedan används ett annat datorverktyg för att verifiera att det utformade byggnadsverket kan hantera de krafter som uppstår, t.ex. vind, egentyngd osv. Detta arbeteBefore a new structure can be built, it must be designed. This design phase is a very important step in the building process. The total cost of the structure and its structural performance are largely dependent on the structural design process. The impact of decisions on the design process is initially high and declines as the design matures. However, few computational tools are available for the

The purpose of dynamic asset allocation (DAA) is to overcome the challenge that changing market conditions present to traditional strategic asset allocation by adjusting portfolio weights to take advantage of favorable conditions and reduce potential drawdowns. This article proposes a new approach to DAA that is based on detection of change points without fitting a model with a fixed number of reg

Purpose – The purpose of this paper is to explore, illustrate, and conceptualize how sustainability service is performed and the role it plays in the promotion of sustainable consumption. Design/methodology/approach – Theoretically, this paper takes a practice theory approach, conceptualizing the provision of sustainability service as a set of complex, socio-material, and performative practices. M

ObjectivesThe objective of our article is to show how “quality of evidence” and “imprecision,” as they are defined in Grading of Recommendations Assessment, Development, and Evaluation (GRADE) articles, may lead to confusion. We focus only on the context of systematic reviews.Study Design and SettingWe analyze, with the aid of standard probabilistic and statistical concepts, the concepts of qualitThe objective of our article is to show how “quality of evidence” and “imprecision,” as they are defined in Grading of Recommendations Assessment, Development, and Evaluation (GRADE) articles, may lead to confusion. We focus only on the context of systematic reviews.

Report on the medieval parish church of Stora Köpinge in Scania, Sweden. The report is part of a never fullfiled plan of publishing short building archaeological reports on all the medieval churches of the two counties Ljunits and Herrestad at Ystad in Scania as part. The investigation was conducted as a part of the research project "The Cultural Landscape during 6000 years in Southern Sweden", al

Katedralen var en av de mest centrala institutionerna i det medeltida samhället. Kring stiftets biskop samlades den kyrkliga makten och dåtidens elit, dygnet runt firades gudstjänster och här utbildades stiftets präster. En viktig roll för livet i och kring katedralen hade domkapitlet eller katedralkapitlet, dvs det organiserade prästerskap som betjänade domkyrkan och bistod biskopen.I mitt avhandThe cathedral was one of the most important institutions in medieval Europe. The local as well as ecclesiastical elite gathered around it and its bishop; the liturgy was celebrated day and night, year after year; the cathedral served as educational institution of the clergy. The cathedral chapter, i.e. the organized clergy that served at the cathedral, played a decisive part in all this.The overar

Kolhydratsystem så som alkylglycosider, cellulosa och cyklodextrin är miljövänliga förnybara material som används inom många områden i dagens samhälle; som bärare av aktiva substanser i läkemedelstabletter, matsmältningsfiber, papper, kosmetika och hygienartiklar för att nämna några. De är fasta substanser uppbyggda av molekyler ordnade i en viss struktur. Med tiden, och eventuell yttre påverkan, In the solid state, molecules are normally ordered in a specific structure. With time, and as a result of influence from the surroundings, solid materials can change their molecular and/or crystal structure and, as a consequence, obtain completely different properties. Water is particularly important in this respect. Adsorption of minuscule amounts of water from the atmosphere may have huge effect