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Left atrial reservoir strain (LASr) offers diagnostic and prognostic value in patients with heart failure. However, LASr may be technically challenging and is not available to all clinical echocardiographers. Since LASr is a consequence of left atrial (LA) stretch during apical descent of the mitral annulus, we hypothesized that a ratio between mitral annular plane systolic excursion (MAPSE) and L

Background: Despite the efficacy of SARS-CoV-2 vaccines in reducing mortality and severe cases of COVID-19, a proportion of survivors experience long-term symptoms, known as post-acute sequelae of SARS-CoV-2 infection (PASC). This study investigates the long-term immunological and neurodegenerative effects associated with extracellular vesicles (EVs) in COVID-19 survivors, 15 months after SARS-CoV

Introduction: Population-based registers provide an important source of real-world data. The growing number of large cohort studies using data from cancer registers makes validation of such registers important. The Swedish Quality Register of Gynecologic Cancer (SQRGC) is a nationwide population-based register containing data on patient and tumor characteristics, treatment, and follow-up. To ensur

The construction industry has a great impact on the environment but there is a great potential for improvements. In the era of climate change, sustainable construction methods and ecological solutions are required to improve energyefficiency, and to decrease the environmental impact of housing development. Circular Economy is considered a feasible solution to global sustainability issues and relat

Conventional Quality of Service(QoS) measurements are incapable to meet the demand for analysing communication performance on timeliness of information in Industrial Control Networks with many connected subsystems. The Age of Information (AoI) and the Age of Actuation (AoA) give a promise to be a solution. Many recent research articles cover theoretical aspects and analyse performance characterist

In the ocean, carbon export is driven by the biological carbon pump where organic matter is transported from the surface layer to the deep sea. The sinking particulate organic matter is mainly a product of phytoplankton aggregates and faecal pellets from zooplankton & fish, together also known as “marine snow”. Marine snow is continuously being degraded by microbial and zooplankton activities

According to sexual selection theory, males should benefit more from mating with multiple partners than females do as male investment into offspring production is typically lower. However, male reproductive success might not increase indefinitely with an increasing number of female mating partners. Male ejaculates are limited, and so mating with multiple females over a short period of time may cau

Global rising temperatures is impacting species interactions worldwide including those between host and parasites. A long-term study on a population of blue tits (Cyanistes caeruleus) linked increases in avian malaria parasites to rising temperatures. Understanding the consequences that these increases in avian malaria parasites are causing is vital. Therefore, data from the past 28 years on this

In developing EnergyNet we have leveraged and are extending lessons from telecom's shift from a centralized, circuit-switched phone system to decentralized, packet-switched data networks. EnergyNet utilizes 1) an Energy Router that enforces galvanic separation and utilizes software-controlled energy flows over a DC backplane, 2) Energy Local and Wide Area Networks (ELAN/EWAN) based on DC microgridIn developing EnergyNet we have leveraged and are extending lessons from telecom's shift from a centralized, circuit-switched phone system to decentralized, packet-switched data networks. EnergyNet utilizes 1) an Energy Router that enforces galvanic separation and utilizes software-controlled energy flows over a DC backplane, 2) Energy Local and Wide Area Networks (ELAN/EWAN) based on DC microgrid

Infant Acute Lymphoblastic Leukemia (ALL) driven by the KMT2A::AFF1 onco-fusion is an aggressive, poor prognosis disease with few co-operative mutations. The fusion originates in utero, yet the embryonic initiating steps of disease development remain poorly understood. Here, we present a novel murine KMT2A::AFF1 model, that provides key insights into KMT2A::AFF1 pre-leukemia, relevant to human dis

BackgroundAirway hyperresponsiveness (AHR), a key feature of asthma, leads to airway narrowing in response to bronchoconstrictor stimuli. Notably, AHR is also observed in individuals with chronic obstructive pulmonary disease (COPD). The Mannitol challenge test is an indirect method to assess airway hyperresponsiveness.ObjectiveThe primary aim of this study was to explore airway hyperresponsivenes

Background and purpose — Traditional surgery forarthritis of the distal radioulnar joint (DRUJ), which typicallyinvolves resecting the ulnar head, is being increasingly challengedby newer techniques, such as prosthetic ulnar headreplacement. The aim of our prospective cohort study was toinvestigate the clinical and patient-reported functional results,up to 2 years postoperatively, among patients w

INTRODUCTION: We investigated the natural history of the relationship between PSA at age 60 and lifetime risk of prostate cancer death in an unscreened cohort followed for 40 years, the Malmö Preventive Project. We also investigated whether percent free PSA could risk-stratify men with low PSAs.METHODS: The cohort included 1162 men aged 58-62 at blood draw in 1981-82, with 1151 deaths by December

IMPORTANCE: Repeating a prostate-specific antigen (PSA) test after an elevated measurement is a guideline-recommended component of the prebiopsy workup. However, it is unclear whether certain patients can be exempted from repeat PSA testing and proceed directly to further workup.OBJECTIVE: To determine yearly PSA variability and implications of repeating an elevated PSA in the Prostate, Lung, Colo

After the clinical implementation of amyloid-β-targeting therapies for people with cognitive impairment due to Alzheimer's disease (AD), there is an urgent need to efficiently identify this patient population in primary care. Therefore, we created a brief and self-administered digital cognitive test battery (BioCog). Based on its sub-scores, a logistic regression model was developed in a secondary

INTRODUCTION: Inflammation is integral to wound healing; yet, its dynamics in normally healing epidermal wounds are not fully characterized. To this end, we analyzed longitudinal wound fluid samples collected from epidermal suction blister wounds in healthy volunteers.MATERIALS AND METHODS: A total of 48 control wounds were induced by suction blister method in 24 healthy volunteers-1 on each thigh

Objectives:To determine the cumulative live birth rate (CLBR) under three consecutive in vitro fertilisation (IVF) treatments in women with endometriosis and/or adenomyosis.Methods:A prospective cohort study of 1035 women aged 25–≤39 years undergoing up to three consecutive IVF treatments between January 2019 and April 2024. All women underwent an advanced transvaginal ultrasound examination prior

Ante el incremento continuo desde 2015 del número de personas desplazadas por la fuerza y el declive de las fuentes tradicionales de financiamiento público destinadas a la ayuda humanitaria, que ha culminado con el desmantelamiento de la Agencia de Estados Unidos para el Desarrollo Internacional (USAID), ha surgido la necesidad de buscar soluciones innovadoras para financiar las respuestas a los d