Background: Tumour-infiltrating lymphocytes (TILs) are of important prognostic and predictive value in human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC) and triple-negative breast cancer (TNBC), but their clinical relevance in oestrogen receptor-positive/HER2-negative (ER+/HER2−) remains unknown. The primary study aim was to analyse the prognostic effect of TILs on the B

Crowdfunding in tourism and leisure projects appears to be growing. However, little is known about why individuals participate in incentive crowdfunding from a theoretical perspective. To address the research question, this study aims to compare a theoretically integrated model regarding linkages among antecedents, attribution, trust, and behavior. This study conducted an online survey to collect

The sustainability of complex resource systems, such as the food, water, and energy (FWE) nexus, is increasingly threatened by climate change impacts, expanding populations, urbanization, and economic instability. However, while research on the topic has burgeoned, studies focused on solution development and implementation, especially at the urban level, have lagged behind. Against this background

IMPORTANCE Treatment trials require sound knowledge on the natural course of disease. OBJECTIVE To assess clinical features, genetic findings, and genotype-phenotype correlations in patients with retinitis pigmentosa (RP) associated with biallelic sequence variations in the PDE6A gene in preparation for a gene supplementation trial. DESIGN, SETTING, AND PARTICIPANTS This prospective, longitudinal,

Purpose: To describe the stages of development and natural course of a full-thickness macular hole (FTMH) in a patient with enhanced S-cone syndrome (ESCS). Methods: This study reported the serial ophthalmologic examinations and macular spectral-domain optical coherence tomography (SD-OCT) imaging over a period of 6 years in a 29-year-old man with ESCS confirmed by electroretinography (ERG) and NR

Background: Sensitization to acrylates is a concern in the occupational/environmental dermatology field. Objective: To describe an occupational allergic contact dermatitis (ACD) outbreak from a smartphone screen protector glue. Methods: Thirteen affected workers of a chain store selling phone screen protectors were investigated in five Spanish dermatology departments. The glue datasheet and label

Strax sydöst om Ronneby i anslutning till Angelåns utlopp i Angelskogsviken, öster om Ronnebyhamn , ligger en anläggning som i folkmun kallas ”Hagbards källare”. Det utgör resterna av ett medeltida torn. Artikeln berättar om de preliminära resultaten av en arkeologisk undersökning 2021.

Vertically aligned metal halide perovskite (MHP) nanowires are promising for various optoelectronic applications, which can be further enhanced by heterostructures. However, present methods to obtain free-standing vertically aligned MHP nanowire arrays and heterostructures lack the scalability needed for applications. We use a low-temperature solution process to prepare free-standing vertically al

How can an online course be designed to promote better mood and improved lighting and darkness conditions in the home? Based on the Information-Motivation-Behaviour Skills Model, the online course comprises multiple components (light, activity and sleep) and various learning strategies. Factual information is provided about, e.g. light as the most potent external time cue for the internal body cloHow can an online course be designed to promote better mood and improved lighting and darkness conditions in the home? Based on the Information-Motivation-Behaviour Skills Model, the online course comprises multiple components (light, activity and sleep) and various learning strategies. Factual information is provided about, e.g. light as the most potent external time cue for the internal body clo

Background: Prophylactic lightweight mesh in the sublay position reduced the cumulative incidence of parastomal hernia (PSH) after cystectomy with ileal conduit diversion in a randomised controlled trial.Objective: To investigate whether the use of prophylactic mesh is cost-effective in comparison to no mesh from the health care provider perspective.Design setting and participants: Data on health

Follow-on pharmaceutical innovation occurring after the initial discovery of a drug active ingredient plays an important, but at times underappreciated, role in providing innovative solutions to compelling medical needs. Examples of follow-on innovation include new forms of a drug with improved safety-efficacy profiles, new formulations and dosages providing improved patient outcomes, and new meth

BACKGROUND: Extensive exposure to per-and polyfluoroalkyl substances (PFAS) have been observed in many countries. Current deterministic frame-works for risk assessment lack the ability to predict the likelihood of effects and to assess uncertainty. When exposure exceeds tolerable intake levels, these shortcomings hamper risk management and communication. OBJECTIVE: The integrated probabilistic ris

Multiplicity and pseudorapidity (η) density (dN ch/dη) distributions of charged hadrons provide key information towards understanding the particle production mechanisms and initial conditions of high-energy heavy-ion collisions. However, detector constraints limit the η-range across which charged particle measurements can be carried out. Extrapolating the measured distributions to large η-range by

Pressurised meltwater has a major impact on ice dynamics, as well as on sedimentary and deformational processes occurring below/in front of glaciers and ice sheets, but its role in glaciotectonic processes is yet to be fully understood. This study explores micro- and macroscale structures developed within décollements in two thrust-block moraines of Late Weichselian age in Melasveit, western Icela

Objectives: To compare the performance of ultrasound measurements and subjective ultrasound assessment (SA) in detecting deep myometrial invasion (MI) and cervical stromal invasion (CSI) in women with endometrial cancer, overall and according to whether they had low- or high-grade disease separately, and to validate published measurement cut-offs and prediction models to identify MI, CSI and high-

This paper employs Swedish data on households' stock holdings to investigate how consumption responds to changes in stock market returns. We instrument the actual capital gains and dividend payments with past portfolio weights. Unrealized capital gains lead to a marginal propensity to consume of 23% for the bottom 50% of the wealth distribution and about 3% for the top 30% of the wealth distributi

Dietary carbohydrates have long been expected to be associated with risk of type 2 diabetes; however, the associations for many carbohydrates and carbohydrate-rich foods remain inconclusive. This study analysed associations between intakes of six types of carbohydrates and thirteen carbohydrate-rich foods with incident type 2 diabetes in 26 622 participants (61% women) in the Malmö Diet and Cancer

BACKGROUND: Gastrectomy including D2 lymphadenectomy is regarded as the standard curative treatment for advanced gastric cancer in Asia. This procedure has also been adopted gradually in the West, despite lack of support from RCTs. This study sought to investigate any advantage for long-term survival following D2 lymphadenectomy in routine gastric cancer surgery in a Western nationwide population-

Purpose: To compare rates of tau biomarker positivity (T-status) per the 2018 Alzheimer’s Disease (AD) Research Framework derived from [18F]flortaucipir (FTP) PET visual assessment, FTP quantification, and cerebrospinal fluid (CSF) phosphorylated Tau-181 (PTau181). Methods: We included 351 subjects with varying clinical diagnoses from three cohorts with available FTP PET and CSF PTau181 within 18