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Mutations in Cytoplasmic Loops of the KCNQ1 Channel and the Risk of Life-Threatening Events Implications for Mutation-Specific Response to beta-Blocker Therapy in Type 1 Long-QT Syndrome

Background-beta-Adrenergic stimulation is the main trigger for cardiac events in type 1 long-QT syndrome (LQT1). We evaluated a possible association between ion channel response to beta-adrenergic stimulation and clinical response to beta-blocker therapy according to mutation location. Methods and Results-The study sample comprised 860 patients with genetically confirmed mutations in the KCNQ1 cha

Exponential Algorithms: Algorithms and Complexity Beyond Polynomial Time

This report documents the program and the outcomes of Dagstuhl Seminar 13331 "Exponential Algorithms: Algorithms and Complexity Beyond Polynomial Time". Problems are often solved in practice by algorithms with worst-case exponential time complexity. It is of interest to find the fastest algorithms for a given problem, be it polynomial, exponential, or something in between. The focus of the Seminar

The Soluble Form of the Axl Receptor Tyrosine Kinase

The present investigation focus on the receptor Axl, which is a member of the receptor tyrosine kinase family. Axl is activated by the ligand Gas6 inducing cell growth and proliferation, but also regulate inflammation and vascular homeostasis. The Axl receptor can be cleaved outside the membrane, releasing the extracellular, soluble domain, which alone can bind Gas6, removing it from cellbound rec

Relatedness and technological change in cities: the rise and fall of technological knowledge in US metropolitan areas from 1981 to 2010

This article investigates by means of US Patent and Trademark Office (USPTO) patent data whether technological relatedness at the city level was a crucial driving force behind technological change in 366 US cities from 1981 to 2010. Based on a three-way fixed-effects model, we find that the entry probability of a new technology in a city increases by 30% if the level of relatedness with existing t

Stripes disrupt odour attractiveness to biting horseflies: Battle between ammonia, CO2, and colour pattern for dominance in the sensory systems of host-seeking tabanids

As with mosquitoes, female tabanid flies search for mammalian hosts by visual and olfactory cues, because they require a blood meal before being able to produce and lay eggs. Polarotactic tabanid flies find striped or spotted patterns with intensity and/or polarisation modulation visually less attractive than homogeneous white, brown or black targets. Thus, this reduced optical attractiveness to t

A B-10-based neutron detector with stacked MultiWire Proportional Counters and macrostructured cathodes

We present the results of the measurements of the detection efficiency for a 4.7 angstrom neutron beam incident upon a detector incorporating a stack of up to five MultiWire Proportional Counters (MWPC) with Boron-coated cathodes. The cathodes were made of Aluminum and had a surface exhibiting millimeter-deep V-shaped grooves of 45 degrees, upon which the thin Boron film was deposited by DC magnet

Mechanisms of defective insulin secretion in type 2 diabetes

Popular Abstract in Swedish Diabetes, i dagligt tal även kallat sockersjuka, kännetecknas av konstant förhöjt blodsocker. Sjukdomen ökar lavinartat, och har beskrivits som en av det moderna samhällets stora epidemier. Diabetes förekommer i två huvudsakliga former, typ 1 och typ 2. I typ 1-diabetes, som framför allt drabbar barn och ungdomar, har de insulinproducerande beta-cellerna förstörts av krDefective insulin secretion from the pancreatic B-cells is a central feature in type 2 diabetes (T2D). There is a strong hereditary component in type T2D, but the underlying pathophysiology remains largely unknown. This thesis uses a combination of gene network analysis and cell-physiological techniques to explore the genetic and cellular basis for impaired insulin secretion in T2D. We found that

Fläderskära funnen i Blekinge – inkommen med importerad vass

Fläderskära är en nordamerikansk art som spritt sig till de tempererade delarna av Europa. Introduktionen till Blekinge är intressant, eftersom arten följde med importerad vass från Tyskland, som skulle användas som en s.k. kvävefälla till Kallinge flygplats utanför Ronneby. Fläderskäran förekommer här i ett rikt bestånd och kanske den etablerar sig.

Women with comorbid substance dependence and psychiatric disorders in Sweden: a longitudinal study of hospital care utilization and costs.

Substance use disorders are regarded as one of the most prevalent, deadly and costly of health problems. Research has consistently found that the prevalence of other psychiatric disorders among those with substance related disorders is substantial. Combined, these disorders lead to considerable disability and health years lost worldwide as well as extraordinary societal costs. Relatively little of

Neonatal resuscitation - studies in piglets

Background and aims: “It’s best to start with air” states the current guidelines on the resuscitation of babies at birth. In a piglet model mimicking severe neonatal asphyxia and circulatory arrest, different aspects of resuscitation were investigated (studies I-III). The hypotheses were that the return of spontaneous circulation (ROSC) would occur faster with the use of oxygen (I and III) or adre

Using GNG to improve 3D features extractio - Application to 6DoF Egomotion

Abstract in UndeterminedSeveral recent works deal with 3D data in mobile robotic problems, e.g. mapping or egomotion. Data comes from any kind of sensor such as stereo vision systems, time of flight cameras or 3D lasers, providing a huge amount of unorganized 3D data. In this paper, we describe an efficient method to build complete 3D models from a Growing Neural Gas (GNG). The GNG is applied to t

Instrumentation, Control and Automation in wastewater - from London 1973 to Narbonne 2013

Key developments of instrumentation, control and automation (ICA) applications in wastewater systems during the past 40 years are highlighted in this paper. From the first ICA conference in 1973 through to today there has been a tremendous increase in the understanding of the processes, instrumentation, computer systems and control theory. However, many developments have not been addressed here, s

Search for first generation scalar leptoquarks in pp collisions at root s=7 TeV with the ATLAS detector

We report a search for first generation scalar leptoquarks using 1.03 fb(-1) of proton-proton collisions data produced by the Large Hadron Collider at root s = 7 TeV and recorded by the ATLAS experiment. Leptoquarks are sought via their decay into an electron or neutrino and a quark, producing events with two oppositely charged electrons and at least two jets, or events with an electron, missing t

Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness.

Metabolite concentrations reflect the physiological states of tissues and cells. However, the role of metabolic changes in species evolution is currently unknown. Here, we present a study of metabolome evolution conducted in three brain regions and two non-neural tissues from humans, chimpanzees, macaque monkeys, and mice based on over 10,000 hydrophilic compounds. While chimpanzee, macaque, and m