Deoxyribonucleoside kinases are feedback inhibited by the final products of the salvage pathway, the deoxyribonucleoside triphosphates. In the present study, the mechanism of feedback inhibition is presented based on the crystal structure of a complex between the fruit fly deoxyribonucleoside kinase and its feedback inhibitor deoxythymidine triphosphate. The inhibitor was found to be bound as a bi

In 1962, the first thorough investigation into the expansion of the Swedish public sector was presented as a doctoral dissertation by Erik Höök. This article investigates the origin and reception of this thesis. Höök’s work has been consid ered a standard work of financial statistics. However, it attracted heavy criticism in the media and from other academics for having explained the public sector

Background: Patients with chronic kidney disease (CKD) have poor outcomes following myocardial infarction (MI). We performed an untargeted examination of 175 biomarkers to identify those with the strongest association with CKD and to examine the association of those biomarkers with long-term outcomes. Methods: A total of 175 different biomarkers from MI patients enrolled in the Swedish Web-System

A model for mate competition in moths sexually signalling with pheromones is presented. The model has four variables. N is the number of individuals of each sex per area unit. r is the length of the female odour plume as detected by a responding male. ε is a parameter increasing with male ability to discriminate between concentrations. r-ε becomes the competitive part of the female pheromone plume

One of the important challenges for wooden construction is to assure good sound insulation in low-frequency range. To that end, it is important to establish reliable prediction tools to reduce the number of experimental tests and the costs. The study reported here is a first investigation aiming at developing a reliable numerical model to predict the vibration behavior of a cross-laminated timber

In this paper water and salt mass balances for the Dead Sea were modeled. Precipitation, evaporation, river discharges, ground water flows, input/output from potash companies and salt production, and brine discharge were included in the models. The mixing time in the Dead Sea was modeled using a single-layer (well-mixed) a two-layer (stratified) system. Using the single-layer approach the water le

How customers develop purchase intentions in online shopping has been a perennial area of interest. In this research note, we ask whether males and females leverage trust in and perceive reputation of online retailers differently in reporting purchase intentions. Drawing on the broader literature on differences in males and females in online shopping behaviors, we propose that females rely on repu

Water and salt mass balances for the Dead Sea were modeled. Precipitation, evaporation, river discharges, ground water flows, input/output from potash companies and salt production, and brine discharge were included in the models. The mixing time in the Dead Sea was modeled using a single-layer (well-mixed) atwo-layer (stratified) system.Using the single-layer approach the water level was predicte

In this paper we develop a number of generic techniques and algorithms in spectral analysis of large linear approximations for use in cryptanalysis. We apply the developed tools for cryptanalysis of ZUC-256 and give a distinguishing attack with complexity around 2236 . Although the attack is only 220 times faster than exhaustive key search, the result indicates that ZUC-256 does not provide a sour

Background: In Scandinavia, there is a strong tradition for research and quality monitoring based on registry data. In Denmark, Norway and Sweden, 63 clinical registries collect data on disease characteristics, treatment and outcome of various cancer diagnoses and groups based on process-related and outcome-related variables. Aim: We describe the cancer-related clinical registries, compare organiz

There is a growing body of literature investigating if and how monetary policy impacts income inequality. Labor unions are generally found to mitigate income inequality and recent literature highlights that changing labor mar- ket structures, such as de-unionization, may be important for monetary pol- icy. This paper tests whether labor unions influence the impact of monetary shocks on income ineq

Proactive identification of chemicals with skin sensitizing properties is a key toxicological endpoint within chemical safety assessment, as required by legislation for registration of chemicals. In order to meet demands of increased animal welfare and facilitate increased testing efficiency also in nonregulatory settings, considerable efforts have been made to develop nonanimal approaches to repl

To protect public health, heat-related policies are increasingly being adopted by city authorities to address the unequal impact of heatwaves. Ahmedabad’s Heat Action Plan (HAP) is an acclaimed and successful policy response in India and beyond. While the pilot evaluation of the initiative suggests that almost a thousand deaths were avoided annually after its implementation, it is not yet clear wh

Det är dags för ett nytt socialt kontrakt som utgår ifrån individens skyldighet att bidra till ett samhällssystem som tar de ekologiska gränserna på allvar. Staten bör i sin tur garantera att det sätts ett tak på hur jordens resurser ska kunna användas för befolkningens välbefinnande, skriver Jayeon Lindellee och Max Koch.