Background: Mobile health (mHealth), wearable activity trackers (WATs) and other digital solutions could support physical activity (PA) in individuals with hip and knee osteoarthritis (OA), but little is described regarding experiences and perceptions of digital support and the use of WAT to self-monitor PA. Thus, the aim of this study was to explore the experiences of using a WAT to monitor PA an

Aquaporin-9 (AQP9) is a facilitator of glycerol and other small neutral solute transmembrane diffusion. Identification of specific inhibitors for aquaporin family proteins has been difficult, due to high sequence similarity between the 13 human isoforms, and due to the limited channel surface areas that permit inhibitor binding. The few AQP9 inhibitor molecules described to date were not suitable

Colour vision allows animals to use the information contained in the spectrum of light to control important behavioural decisions such as selection of habitats, food or mates. Among arthropods, the largest animal phylum, we find completely colour-blind species as well as species with up to 40 different opsin genes or more than 10 spectral types of photoreceptors, we find a large diversity of optic

Transnational municipal networks (TMNs) have emerged as important actors in the global response to climate change. Environmentalists both within and outside governments have placed great expectations and hopes on these networks. Through their novel form of agency, TMNs are expected to provide cities with a form of ‘extra-legem’ empowerment in their responses to climate change. This empowerment is

In this edited volume, we explored the contributions that political science as a discipline can offer to the evolving Anthropocene debate. The term Anthropocene denotes a new geological epoch in the Earth’s history in which humans have become the main drivers of planetary-wide changes. Some authors interpret this as good news, pointing to progress as a result of human ingenuity and the endless pos

MHC genes are extraordinarily polymorphic in most taxa. Host-pathogen coevolution driven by negative frequency-dependent selection (NFDS) is one of the main hypotheses for the maintenance of such immunogenetic variation. Here, we test a critical but rarely tested assumption of this hypothesis—that MHC alleles affect resistance/susceptibility to a pathogen in a strain-specific way, that is, there i

Introduction: In Sweden, head computed tomography (CT) is commonly used for prediction of neurological outcome after cardiac arrest, as recommended by guidelines. We compare the prognostic ability and interrater variability of routine and novel CT methods for prediction of poor outcome. Methods: Retrospective study including patients from Swedish sites within the Target Temperature Management afte

Background: Few studies have evaluated the efficacy of ketamine-assisted psychotherapy (KAP) in the treatment of treatment-resistant depression (TRD) and substance use disorders (SUD). Methods: A systematic review of clinical trials reporting on the efficacy of KAP and discussing mechanisms of action, identified on PubMed and PsycInfo. Results: Five randomized-controlled trials reported on the eff

In dual control, the manipulated variables are used to both regulate the system and identify unknown parameters. The joint probability distribution of the system state and the parameters is known as the hyperstate. The paper proposes a method to perform dual control using a deep reinforcement learning algorithm in combination with a neural network model trained to represent hyperstate transitions.

Demokratin kräver en fin väv av normer och strukturer för att kunna fungera. De fria allmänna valen är bara en del av många i denna väv. En annan del är starka och modiga professioner i det offentliga kärnuppdraget. Med sitt omdöme och sin professionella etik utgör dessa grupper en trygghet för våra medborgare och för deras talan i många situationer. Det finns flera skäl till att offentlig styrnin

Inom Svenska kyrkan talas idag ofta om vikten av att rekrytera ideella medarbetare. I en tid då de ekonomiska resurserna minskar blir det viktigt att på nytt arbeta med människors engagemang. Vi har vant oss vid att de anställda medarbetarna är många, men hur och varför växte de stora arbetslagen fram?Detta är en bok om hur lekmannamedarbetare kom att bli en naturlig del av den församlingsverksamh

Major atmospheric oxidants (OH,O3 and NO3) dominate the atmospheric oxidation capacity, while H2SO4 is considered as a main driver for new particle formation. Although numerous studies have investigated the long-term trend of ozone in Europe, the trends of OH, NO3 and H2SO4 at specific sites are to a large extent unknown. The one-dimensional model SOSAA has been applied in several studies at the S

Climate change is rapidly altering the Arctic environment. Although long-term environmental observations have been made at a few locations in the Arctic, the incomplete coverage from ground stations is a main limitation to observations in these remote areas. Here we present a wind and sun powered multi-purpose mobile observatory (ARC-MO) that enables near real time measurements of air, ice, land,

Preclinical rodent models of Parkinson’s Disease (PD) based on alpha-synuclein (αSyn) present some of the pathological hallmarks of the human condition, such as the progressive loss of dopaminergic neurons in the substantia nigra (SN) and the development of behavioural deficits. However, numerous reports on these models highlighted the variable outcomes that might originate from them if not valida

A novel method to derive pressure-volume (PV) loops noninvasively from cardiac magnetic resonance images has recently been developed. The aim of this study was to evaluate inter- and intraobserver variability of hemodynamic parameters obtained from noninvasive PV loops in healthy controls, subclinical diastolic dysfunction (SDD), and patients with heart failure with preserved ejection fraction, mi

Background and ObjectivesEEG is widely used for prediction of neurologic outcome after cardiac arrest. To better understand the relationship between EEG and neuronal injury, we explored the association between EEG and neurofilament light (NfL) as a marker of neuroaxonal injury, evaluated whether highly malignant EEG patterns are reflected by high NfL levels, and explored the association of EEG bac

In modern society, the consumption of fossil fuels has been increasing drastically, leading to significant emissions of carbondioxide (CO2), air pollution, global warming, and political and economic imbalances. This has increased the interest inrenewable and sustainable energy sources such as wind- and hydropower, solar energy, and in energy conversion by fuel celltechnology, and water electrolyse

Estimation of the defect content is important to enable quality control throughout the software development process. Capture-recapture methods and curve fitting methods have been suggested as tools to estimate the defect content after a review: The methods are highly reliant on the quality of the data. If the number of reviewers is fairly small, it becomes difficult or even impossible to get relia