FLT3 kinase has become an attractive drug target in AML with up to 30% of cases harboring internal-tandem-duplication (ITD) mutations. For these, conferring a worse prognosis and decreased overall survival, several FLT3 tyrosine kinase inhibitors (TKIs) are currently being tested in clinical trials. However, when using these drugs as monotherapy, the problem of short duration of remissions and hig

In this article, we investigate the nexus of green city branding and municipal climate networks. In recent decades, a number of formal transnational municipal climate networks have emerged and their membership continues to increase. In parallel, city branding that is based on green policies, has gained importance. Based on quantitative and qualitative data, we assess how and to what extent German

Many low-income consumers face a limited budget for food purchases. The United States Department of Agriculture developed the Thrifty Food Plan to address this problem of consuming a healthy diet given a budget constraint. This dietary optimization program uses common food choices to build a suitable diet. In this article, the United States Department of Agriculture data sets are used to test the

Introduction and hypothesis Urinary incontinence (UI) is common among the elderly, but the literature is sparse on the surgical treatment of UI among the elderly. This systematic review aims to assess the effectiveness of surgical interventions as treatment for urinary incontinence in the elderly population >= 65 years of age. Methods Randomized controlled trials (RCT) and prospective nonrandomize

Questions Can the model performance of the landscape reconstruction algorithm (LRA) for small forest hollows be validated through comparison to inventory-based vegetation reconstructions from the last 150yrs? Does the application of LRA and the comparison to historical data enhance interpretation of the pollen record? Location Denmark. The Gribskov-Ostrup small forest hollow (56 degrees N, 12 degr

Inhibitors of the mammalian target of rapamycin (mTORi) can produce de novo proteinuria in kidney transplant patients. On the other hand, mTORi has been shown to suppress disease progression in several animal models of kidney disease. In the present study we investigated whether glomerular permeability can be acutely altered by the mTORi, temsirolimus, and whether mTORi can affect acute purumycin

To establish an experimental model for acute ischaemic isolated right ventricular dysfunction and the subsequent haemodynamic changes.

SCF (Skp1/Cul1/F-box) ubiquitin ligases act as master regulators of cellular homeostasis by targeting key proteins for ubiquitylation. Here, we identified a hitherto uncharacterized F-box protein, FBXO28 that controls MYC-dependent transcription by non-proteolytic ubiquitylation. SCFFBXO28 activity and stability are regulated during the cell cycle by CDK1/2-mediated phosphorylation of FBXO28, whic

Reduced irregularity of RR intervals in permanent atrial fibrillation (AF) has been associated with poor outcome. It is not fully understood, however, whether modification of atrioventricular (AV) conduction using rate-control drugs affects RR variability and irregularity measures. We aimed at assessing whether atrial fibrillatory rate (AFR) and variability and irregularity of the ventricular rate

Four different elastic models for sheathing-to-framing connections are presented and evaluated on asingle connection level and on a shear wall level. Since the models are elastic in their nature they aresuitable mainly for cases where the sheathing-to-framing connections are subjected to monotonicallyincreasing displacements. Of the four models one is uncoupled and the others are coupled with resp

Expanding hypoxia in the Baltic Sea over the past century has led to the development of anoxic and sulfidic (euxinic) deep basins that are only periodically ventilated by inflows of oxygenated waters from the North Sea. In this study, we investigate the potential consequences of the expanding hypoxia for manganese (Mn) burial in the Baltic Sea using a combination of pore water and sediment analyse

Background: Activity performance is marked by the degenerative nature of Parkinson's disease (PD), but few qualitative studies have focused on how people with PD perceive participation in life situations. Objective: To identify and describe barriers and facilitators for participation from the perspective of people with PD. Methods: Qualitative data was obtained by the focus group method using a se

Aldehyde dehydrogenase family 1 member A1 (ALDH1A1) is a putative marker of breast cancer stem cells (CSCs) with prognostic implications when expressed in cancer or stroma. However, previous results are contradictory and we therefore aimed to further evaluate the impact of ALDH1A1 on distant disease-free survival (DDFS) and correlation with clinicopathological variables in breast cancer, specifica

Background: Three-dimensional time-resolved (4D) phase-contrast (PC) CMR can visualize and quantify cardiovascular flow but is hampered by long acquisition times. Acceleration with SENSE or k-t BLAST are two possibilities but results on validation are lacking, especially at 3 T. The aim of this study was therefore to validate quantitative in vivo cardiac 4D-acquisitions accelerated with parallel i

A split sample study was performed on 109 bronchial brushings and washings and evaluated from conventional slides (CS) and CytoRich Red/Tripath preparations (CRR/Tripath). Unassessable bronchial washings were significantly more frequent in CS (5 vs. 0), but as all brushings were assessable with both methods, no overall diagnostic advantage was found. CS and CRR/Tripath gave discordant diagnoses in

Severe cracks have been found in several box-girder bridges in Sweden, with the cracks being more frequent on the south side than the north. This indicates that solar radiation has a large impact on the stress field of these bridges, since this is the only factor that is significantly different between the walls. In this study the Vätösund Bridge has been modelled in a 3D FE-model to analyse the t

Streptococcal toxic shock syndrome is frequently caused by Streptococcus pyogenes of the M1 serotype. The aim of this study was to determine the role of Ras-homologous (Rho)-kinase signaling in M1 protein-provoked lung damage. Male C57BL/6 mice received the Rho-kinase-specific inhibitor Y-27632 before administration of M1 protein. Edema, neutrophil accumulation and CXC chemokines were quantified i