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We here discuss the potential theranostic nanomedicine application of an innovative formulation consisting of monoolein-based nanoparticles with a two-dimensional hexagonal inner structure stabilized in water using a mixture of PEO132-PPO50-PEO132 block copolymers with and without conjugated folate for targeting. The proposed tumor-cell targeted formulation was shown to be able to simultaneously h

This narratological study deals with the stance of irony in Jane Austen’s juvenilia. It looks for ‘gaps’ between the attitudes of implied authors, narrators and characters, and investigates how these gaps contribute to the irony of the texts. Once it has been established that the implied author has an ‘ironic intent’, the primary question is whether the narrator shares this intent. Some narrators

We consider the problem of constructing linear precoders for quasi-stationary multiple-input multiple-output channels. Maximum-likelihood detection is assumed and the objective of the precoding is to maximize the minimum Euclidean distance of the signaling. Since the channel remains constant for some time, the precoding is performed spatially as well as across time. As will be shown, the precoder

An analysis of transient thermal substrate effects impairing the sensitivity of the DCS path in a tri-band GSM/DCS/PCS BiCMOS radio receiver is presented in this paper. A simple thermal model of the substrate is employed, enabling concurrent electrothermal circuit-substrate simulations within a standard analog circuit simulator. Simulation results obtained with this approach match very closely the

The standard model (SM) of particle physics is spectacularly successful, yet the measured value of the muon anomalous magnetic moment (g - 2)mu deviates from SM calculations by 3.6 sigma. Several theoretical models attribute this to the existence of a "dark photon," an additional U(1) gauge boson, which is weakly coupled to ordinary photons. The PHENIX experiment at the Relativistic Heavy Ion Coll

Objective: Transcatheter valve-in-valve implantation has emerged as an option, in addition to reoperative surgical aortic valve replacement, to treat failed biologic heart valve substitutes. However, the clinical experience with this approach is still limited. We report the comprehensive experience of transcatheter valve-in-valve implantation in the Nordic countries from May 2008 to January 2012.

The plant polysaccharide degradative potential of Aspergillus nidulans was analysed in detail and compared to that of Aspergillus niger and Aspergillus oryzae using a combination of bioinformatics, physiology and transcriptomics. Manual verification indicated that 28.4% of the A. nidulans ORFs analysed in this study do not contain a secretion signal, of which 40% may be secreted through a non-clas

Many of the interesting physics processes to be measured at the LHC have a signature involving one or more isolated electrons. The electron reconstruction and identification efficiencies of the ATLAS detector at the LHC have been evaluated using proton-proton collision data collected in 2011 at TeV and corresponding to an integrated luminosity of 4.7 fb. Tag-and-probe methods using events with lep

Intensive agricultural practices can dramatically change the landscape, thereby increasing the concentrations and rates at which nutrients are delivered to aquatic ecosystems. In the United States, concerns about accelerating rates of lake eutrophication related to increases in nutrient loading require a method of quantifying ecological changes that have occurred since European settlement. Because

We have examined the timing of calling behavior in the female Egyptian cotton leafworm, Spodoptera littoralis and its modification by exposure to sex pheromone. The calling rhythm of the female moth was found to be circadian, persistent for at least 4days once it has been entrained, and could be phase shifted by altering the light:dark regime. We also found that female exposure to pheromone affect

Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy encountered in diabetes. The short-term improvement after carpal tunnel release has previously been demonstrated not to differ between patients with and without diabetes, despite a marked impairment in health-related quality of life (HRQL) among the former. In this study, we compare HRQL 5 years after carpal tunnel release betwe

Purpose - The article has two major purposes. The first purpose is to examine the roles and practices of communication professionals in relation to internal aspects of crisis communication. The second purpose is to suggest new roles and practices for communication professionals that will enable a strategic approach to internal crisis communication. This article is based on empirical material from

Background: Plasmodium falciparum EBA175 and PfRh2 belong to two main families involved in parasite invasion, and both are potential vaccine candidates. Current knowledge is limited regarding which target antigens and subclasses of antibodies are actually important for protection, and how naturally acquired immunity is achieved. Methods: Repeated blood samples were collected from individuals in Ni

The classical Kalman-Yakubovich-Popov lemma gives conditions for solvability of a certain inequality in terms of a symmetric matrix. The lemma has numerous applications in systems theory and control. Recently, it has been shown that for positive systems, important versions of the lemma can equivalently be stated in terms of a diagonal matrix rather than a general symmetric one. This paper generali

Popular Abstract in Swedish Hur kan svenska myndigheter förbereda sig för att hantera nästa kris när det gäller tillgängligheten av deras mest kritiska informationssystem? Det är den centrala frågan i denna avhandling. Svenska myndigheter och kommuner har en central roll i det svenska krishanteringssystemet. Givetvis är svenska kommunala och statliga verksamheter väldigt beroende av IT-system. SjAs our dependence on IT systems increases, evaluating the dependability of critical IT systems becomes more important. This is especially true for systems that are critical in a crisis situation and whose dependability is an important factor in an organisation's capability to resolve a crisis. Because crisis situations are typically rare events, both the dependability and the criticality of IT sys

Habitat area is an important predictor of spatial variation in animal densities. However, the area often correlates with the quantity of resources within habitats, complicating our understanding of the factors shaping animal distributions. We addressed this problem by investigating densities of insect herbivores in habitat patches with a constant area but varying numbers of plants. Using a mathema