Objective: To explore the involvement of the wingless-type MMTV integration site (WNT) and bone morphogenetic protein (BMP) antagonists dickkopf-related protein 1 (DKK1), frizzled-related protein (FRZB) and gremlin 1 (GREM1) in knee injury and osteoarthritis (OA). Design: The antagonists were immunoassayed in synovial fluid from a cross-sectional cohort of nine knee healthy reference subjects, pat

Background--Interleukin-23 (IL-23) has been implicated in inflammatory and autoimmune diseases by skewing CD4+ T helper cells towards a pathogenic Th17 phenotype. In this study we investigated the presence of IL-23 receptor (IL-23R)-expressing cells in the atherosclerotic aorta and evaluated the effect of IL-23R deficiency on atherosclerosis development in mice. Methods and Results--We used hetero

Objectives: Indications for pulmonary valve replacement (PVR) in patients with pulmonary regurgitation (PR) after repaired tetralogy of Fallot (rToF) are debated. We aimed to compare right (RV) and left ventricular (LV) kinetic energy (KE) measured by 4D-flow magnetic resonance imaging (MRI) in patients to controls, to further understand the pathophysiological effects of PR. Methods: Fifteen patie

Reality television is a term that describes a mixture of fact and drama. We cannot understand reality television in isolation, but part of wider social and cultural phenomena, including production practices, communicative modes, and audience practices. As an inter-generic space reality television occupies the world space of observable phenomena, the dramatic space of entertainment, and the enterta

Background--Both the adrenergic and renin-angiotensin systems contribute to orthostatic circulatory homeostasis, which is impaired in postural orthostatic tachycardia syndrome (POTS). Activating autoantibodies to the α1-adrenergic and β1/2-adrenergic receptors have previously been found in sera from patients with POTS. We hypothesized that patients with POTS might also harbor activating autoantibo

The glucocorticoid receptor (GR) is a nuclear hormone receptor that regulates key genes controlling development, metabolism, and the immune response. GR agonists are efficacious for treatment of inflammatory, allergic, and immunological disorders. Steroid hormone binding to the ligand-binding domain (LBD) of GR is known to change the structural and dynamical properties of the receptor, which in tu

Standards, that is, a set of rules, norms or measures that establish a degree of uniformity such that idiosyncratic instances can be subjected to comparative evaluation, have long been recognized as fundamental to the production of economic efficiency. For instance, the division of labor, which underpins not only global trade but also innovation, relies on standards (Smith, 1776). Specifically, se

As the new generation of Information Technology is progressing at a rapid pace, with big data establishing a trend in organisations, integration between systems becomes substantial. In this chapter, we particularly look at information security as a system that has become an essential part of Business Intelligence (BI). BI systems represent one type of decision support system (DSS) with a focus on

A novel pilot-control angle globe valve is proposed, and it has an obvious advantage of energy conservation during its opening and closing process. In pilot-control angle globe valve, the opening and closing forces are related to the orifice located inside the valve core. In this paper, the effects of orifice diameter are thoroughly studied under different working conditions such as valve core dis

REVIEW QUESTION/OBJECTIVE: The objectives of this review are to explore parents' experiences of communication with healthcare professionals and to identify the meaningfulness of communication to parents in the neonatal intensive care unit (NICU).More specifically, the objectives are to identify.

Bröst- och hudcancerceller sprider sig via lymfatiska systemet och fastnar i en eller två regionala sentinel lymfnoder (SLN) där de med stor sannolikhet växer till metastaser. Därför är SLN-biopsier och relaterade histopatologiska undersökningar viktiga vid cancerdiagnostiken för att bestämma sjukdomsstatus och att från denna kunna bestämma rätt behandling. Patienter vars lymfnoder innehåller spriBreast cancer and malignant melanoma disseminate through the lymphatic system and the first metastases arise in one or two regional, sentinel lymph nodes (SLNs) draining the primary tumour site. Therefore, identification and characterization of the SLNs is of major importance for cancer staging and for choice of therapy in patients. The standard clinical procedure relies on lymphoscintigraphy afte

New industries emerge in increasingly complex spatial patterns that challenge existing explanations of industrial path creation. In particular, the case of latecomer regions building up industries in fields that are unrelated to their previous industrial capabilities is not well understood in the literature. This paper aims to address this gap by expanding on an analytical framework that draws on

The purpose of this paper is to describe strategic improvisation, a contemporary concept and approach based on the creative arts and organizational crisis theory, as a valuable approach for communication professionals. Strategic improvisation combines the need for planning and structure with creative action, and is a normative idea of how to work in an efficient way.Design/methodology/approach: Th

Most climate mitigation scenarios involve negative emissions, especially those that aim to limit global temperature increase to 2°C or less. However, the carbon uptake potential in land-based climate change mitigation efforts is highly uncertain. Here, we address this uncertainty by using two land-based mitigation scenarios from two land-use models (IMAGE and MAgPIE) as input to four dynamic globa

BACKGROUND: Blood group phenotype variation has been attributed to potential resistance to pathogen invasion. Variation was mapped in blood donors from Lampang (northern region) and Saraburi (central region), Thailand, where malaria is endemic. The previously unknown blood group allele profiles were characterized and the data were correlated with phenotypes. The high incidence of the Vel-negative

Rapporten sammanfattar resultaten från en experimentell undersökning där murade väggar belastade med samtidigt verkande normallast och moment har förstärkts genom ytarmering. En metod för beräkning av väggars bärförmåga i den aktuella lastsituationen presenteras. Förstärkningstekniken kan användas såväl i samband med renovering och energieffektivisering av fullmurade ytterväggar med omfattande fro

This thesis makes a contribution to matching theory and mechanism design. It consists of four self-contained papers focusing on kidney exchange, object allocation and partnership formation. The first paper, Pairwise Kidney Exchange over the Blood Group Barrier, investigates how the use of immunosuppressive drugs can be implemented within kidney exchange programs. Thanks to advances in medicine, im

Denna doktorsavhandling undersöker samtal om personliga problem i mötet med en specialist i radio. I synnerhet handlar studien om den dynamiska process då förståelse skapas – när upplevelser av personliga bekymmer förklaras och definieras som problem av särskilda slag. Denna meningsskapande process undersöks i detalj så som den utspelar sig i dialoger i radio och mellan programdeltagare och radiolThe dissertation examines how personal troubles are talked about in an encounter with a professional on the public arena of radio broadcasting, where the professional has to meet the challenge of making professional advice not only useful for the person seeking help, but also relevant or interesting for the radio audience. The study explores the dynamic process of shaping an understanding of probl

Background: Kidney disease is recognised as an important worldwide health burden. Kidney failure is the result of acute and chronic kidney disease and is associated with morbidity and mortality. Chronic kidney failure is associated with high-costs for society and low quality of life. Kidney failure may progress to end-stage renal disease (ESRD) that requires dialysis or kidney transplantation with