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The pancreatic islet beta-cells are the target for an autoimmune process that eventually results in an inability to control blood glucose due to the lack of insulin. The different steps that eventually lead to the complete loss of the beta-cells are reviewed to include the very first step of a triggering event that initiates the development of beta-cell autoimmunity to the last step of appearance
BACKGROUND: A role for the transient receptor potential (TRP) A1 ion channel in rat lower urinary tract (LUT) sensation and disease has been proposed, but in the human LUT no information on TRPA1 activity is available. OBJECTIVES: To investigate the distribution of TRPA1 in the human urethra and to study the effect of TRPA1 agonists on isolated urethral strip preparations. DESIGN, SETTINGS, AND PA
Popular Abstract in Swedish Syftet med denna avhandling är att undersöka vilken roll synlighet spelar i skapandet och utmanandet av tillhörighet till politiska gemenskaper. Baserat på en empirisk studie av ryska medier under 2010-talet föreslås ett sätt att teoretiskt begreppsliggöra förhållandet mellan synlighet och tillhörighet, som utgår från idén att vad som blir synligt för en publik och hur,The purpose of this dissertation is to explore the role of visibility in the production and contestation of belonging to political communities. On the basis of an empirical enquiry of Russian media during the 2010s, a theoretical conceptualization of the relation between visibility and belonging is suggested, starting in the idea that what becomes visible to publics and how, and what is rendered i
AIMS: To estimate the willingness to pay for health improvements among participants in the programme "Physical Activity on Prescription". The objective was also to examine predictors such as income, education level, health status, activity level and BMI, differences for long- and short-term health effects of physical activity and differences between a high- and low-intensity activity group. METHOD
In the Alzheimer's disease (AD) brain, binding of Clq within the Cl complex, the initiating molecule of the classical complement pathway, to apoptotic cells, DNA and amyloid-beta (Abeta), the major constituent of senile plaques, can initiate complement activation. However, the extent of activation is determined by the balance between activation and inhibition. Fluid-phase complement inhibitor C4b-
Abstract in UndeterminedCrisis communication is a growing field of research and practice. A weakness in the traditional research field is the lack of theoretical development and the isolated sender and mass communication focus. In the present paper, we challenge traditional research by focusing on the contemporary cultural and ethnic diversity in society from an audience-oriented media perspective
A compact co-located MIMO structure with high port isolation is proposed for 2.4 GHz WLAN application. The antenna structure consists of a proximity-coupled square ring patch antenna, and a probe fed planar inverted F antenna co-located inside. The operating frequency of the two radiators is designed to be at the same frequency, and a high port isolation below 25 dB is achieved with an extremely n
Rationale: Vascular calcification is a significant contributor to cardiovascular morbidity and mortality. We recently reported that cartilage oligomeric matrix protein (COMP) is pivotal for maintaining the homeostasis of vascular smooth muscle cells (VSMCs). Whether COMP affects the process of vascular calcification is unknown. Objective: We aimed to test whether COMP modulates vascular calcificat
BACKGROUND: It is widely believed that cancer can be prevented by high intake of fruits and vegetables. However, inconsistent results from many studies have not been able to conclusively establish an inverse association between fruit and vegetable intake and overall cancer risk. METHODS: We conducted a prospective analysis of the European Prospective Investigation into Cancer and Nutrition (EPIC)
Most adult patients with congenital heart disease (CHD) have reduced aerobic exercise capacity. Their habitual physical activity (PA) level is, however, less well studied. In this study, habitual PA level in a cohort of adults with CHD compared with healthy age- and sex-matched controls was investigated.
In this paper, we study the problem of joint permutor analysis and design for J-dimensional multiple turbo codes with J constituent encoders, J>2. The concept of summary distance is extended to multiple permutors of size N and used as the design metric. Using the sphere-packing concept, we prove that the minimum length-2 summary distance (spread) Dmin,2 is asymptoticly upper-bounded by O(N J-1/J).
Popular Abstract in Swedish Förståelse är ett komplext begrepp. Det används dagligdags utan en motsvarande strikt vetenskaplig definition. Avhandlingen strävar efter att fånga olika aspekter av detta begrepp. Tesen är att förstå handlar om att se ett mönster, i betydelsen att man kan "se" strukturen i en uppgift, en princip eller ett problem. Att se ett mönster innebär också att man uppmärksammar The thesis proposes that understanding is a matter of experiencing a pattern. To experience a pattern involves seeing how a task, principle, or problem space is structured; to attend to the relevant information; and to be able to use that information as it relates to the knowledge domain at hand. The every day concept of understanding, which is a term used in many ways is discussed and it is explo
Extraordinary transmission through subwavelength apertures is usually observed in a narrow bandwidth range, and the transmission outside this range is low, in agreement with classical results. The analysis presented here is based on the Babinet's principle and hence scattering by the complementary structure, where the apertures are replaced by finite scatterers. It is shown that the transmission c
A many-body theory based on nonequilibrium Green functions, in which transport and optics are treated on a microscopic quantum-mechanical basis, is used to compute gain and absorption in the optical and terahertz regimes in quantum cascade laser structures. The relative importance of Coulomb interactions for different intersubband transitions depends strongly on the spatial overlap of the wave fun
