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Unconventional Zwitterionic State of L-Cysteine

We report the signature of an unconventional zwitterion in thick (>40 angstrom) L-cysteine films grown at low temperature (100 K) by means of sublimation in ultrahigh vacuum. Using X-ray photoelectron spectroscopy (XPS) we find that protonated amino groups (57%) are less prevalent than in films grown at higher temperatures. A large majority of the protonated amino groups receive the hydrogen throu

Charged-particle multiplicities in pp interactions measured with the ATLAS detector at the LHC

Measurements are presented from proton-proton collisions at centre-of-mass energies of root s = 0.9, 2.36 and 7 TeV recorded with the ATLAS detector at the LHC. Events were collected using a single-arm minimum-bias trigger. The charged-particle multiplicity, its dependence on transverse momentum and pseudorapidity and the relationship between the mean transverse momentum and charged-particle multi

Galectin binding proteins in serum and bronchoalveolar lavage -in healthy and pathological conditions

Galectins are carbohydrate binding proteins, implicated in conditions of both inflammation and cancer. Connections between chronic inflammation and cancer are proposed by the increased remodelling and proliferation that occurs, leading to enhanced survival and proliferation of malignant cells. Since galectins have been implicated in mechanisms of both chronic inflammation and cancer, we have inves

Probing protein surface accessibility of amino acid substitutions using hydrophobic interaction chromatography.

Hydrophobic interaction chromatography (HIC) has been used to determine the influence of amino acid substitutions on protein retention and thereby their accessibility on the protein surface. The retentions of mutants of green fluorescent protein (GFPuv) and human hemoglobin (Hb) were studied on multimodal HIC media and compared to the hydrophobicities from known hydrophobicity scales with respect

Optimal combination of form and motion cues in human heading perception

We examined what role motion-streak-like form information plays in heading perception. We presented observers with an integrated form and motion display in which random-dot pairs in a 3D cloud were oriented toward one direction on the screen (the form FOE) to form a radial Glass pattern while moving in a different direction in depth (the motion FOE). Observers' heading judgments were strongly bias

Constrainedly fair job assignments under minimum wages

A number of jobs are to be assigned to a greater number of workers. While having to abide by the law of minimum wages, firms must determine who should be assigned which job and at what Salary. In Such situations fair (envy-free) allocations usually fail to exist. To cope with this Situation, this paper proposes a new concept of fairness, called constrained fairness. Among the set of constrainedly

Time-variant analysis and design of a power efficient ISM-band quadrature receiver

In this work a 2.2 GHz quadrature receiver front-end suitable for low-power applications is presented. The low-noise amplifier, the mixer and the voltage-controlled oscillator are merged into a single stage, making the circuit capable of extreme current reuse while keeping it still functional at low supply voltage. A careful linear time-variant analysis is proven to be necessary to accurately pred

Generation and oxidation of aerosol deposited PdAg nanoparticles

PdAg nanoparticles with a diameter of 10 nm have been generated by an aerosol particle method, and supported on a silica substrate. By using a combination of X-ray Energy Dispersive Spectroscopy and X-ray Photoelectron Spectroscopy it is shown that the size distribution of the particles is narrow and that the two metals form an alloy with a mixture of 75% Pd and 25% Ag. Under oxidizing conditions,

Acid-Catalyzed Nucleophilic Aromatic Substitution: Experimental and Theoretical Exploration of a Multistep Mechanism.

The mechanism for the acid-mediated substitution of a phenolic hydroxyl group with a sulfur nucleophile has been investigated by a combination of experimental and theoretical methods. We conclude that the mechanism is distinctively different in nonpolar solvents (i.e., toluene) compared with polar solvents. The cationic mechanism, proposed for the reaction in polar solvents, is not feasible and th

Total Serum Cholesterol and Cancer Incidence in the Metabolic Syndrome and Cancer Project (Me-Can)

Objective: To investigate the association between total serum cholesterol (TSC) and cancer incidence in the Metabolic syndrome and Cancer project (Me-Can). Methods: Me-Can consists of seven cohorts from Norway, Austria, and Sweden including 289,273 male and 288,057 female participants prospectively followed up for cancer incidence (n = 38,978) with a mean follow-up of 11.7 years. Cox regression mo

Hyperlocal event extraction of future events

From metropolitan areas to tiny villages, there is a wide variety of organizers of cultural, business, entertainment, and social events. These organizers publish such information to an equally wide variety of sources. Every source of published events uses its own document structure and provides dierent sets of information. This raises signicant customization issues. This paper explores the possibi

A Theory of Distances in Software Engineering

[Context] Coordinating a software project across distances is challenging. Even without geographical and time zone distances, other distances within a project can cause communication gaps. For example, organisational and cognitive distances between product owners and development-near roles such as developers and testers can lead to differences in understanding and interpretation of the business re

Investigating highly replicated asthma genes as candidate genes for allergic rhinitis

Background: Asthma genetics has been extensively studied and many genes have been associated with the development or severity of this disease. In contrast, the genetic basis of allergic rhinitis (AR) has not been evaluated as extensively. It is well known that asthma is closely related with AR since a large proportion of individuals with asthma also present symptoms of AR, and patients with AR hav

Improving early diagnosis of acute coronary syndrome and resource utilisation in acute chest pain patients

A high volume of acute chest pain patients, poor early diagnosis and high admission rates result in high resource utilization. In 1000 consecutively chest pain patients the majority of the direct cost was found due to admission time. The difference between mean cost of an “ACS-rule-out” admission and a discharge from the ED was 6.2 kSEK (9.7 kSEK in 2011). Early diagnosis can be improved by 1)

Optical atmospheric extinction over Cerro Paranal

Aims. The present study was conducted to determine the optical extinction curve for Cerro Paranal under typical clear-sky observing conditions, with the purpose of providing the community with a function to be used to correct the observed spectra, with an accuracy of 0.01 mag airmass(-1). Additionally, this work was meant to analyze the variability of the various components, to derive the main atm

Reaction Mechanism of Manganese Superoxide Dismutase Studied by Combined Quantum and Molecular Mechanical Calculations and Multiconfigurational Methods.

Manganese superoxide dismutases (MnSODs) are enzymes that convert two molecules of the poisonous superoxide radical into molecular oxygen and hydrogen peroxide. During the reaction, the manganese ion cycles between the Mn(2+) and Mn(3+) oxidation states and accomplishes its enzymatic action in two half-cycles (corresponding to the oxidation and reduction of O(2)(*-)). Despite many experimental and

Simultaneous determination of fragmentation and coalescence rates during pilot-scale high-pressure homogenization

The emulsification process is primarily determined by the rate of fragmentation and coalescence of emulsion drops. However, there is presently no fast, reliable method for measuring these rates for pilot and production scale high pressure homogenizers. In this paper a method for simultaneous estimating fragmentation and coalescence is developed and tested based on the work of Hounslow and Ni (2004

Barnskötarna, förskollärarna och det förtydligade pedagogiska uppdraget

Syftet med rapporten var att med utgångspunkt i den reviderade versionen av förskolans läroplan, Lpfö 98, belysa hur man som yrkesverksam i förskolan upplever den numera framskrivna och allt tydligare åtskillnad i uppdrag mellan förskolans olika yrkeskategorier, främst förskollärare och barnskötare. Vidare belyser rapporten förskolepersonals tankar och åsikter kring förskolechefens uppdrag: - Hur