Chromosomal instability is a known hallmark of many cancers. DNA polymerases represent a group of enzymes that are involved in the mechanism of chromosomal instability as they have a central function in DNA metabolism. We hypothesized that genetic variation in the polymerase genes may affect gene expression or protein configuration and by that cancer risk and clinical outcome. We selected four gen

We have characterized the lipid chain freezing in dilute aqueous vesicle dispersions of the cationic lipid dioctadecyldimethylammonium bromide (DODAB) using wide and small angle X-ray scattering, solid state NMR, DSC, turbidity and density measurements. The lipids freeze in two steps. Above 40 degrees C the chains are fluid and the lipids are in a so-called liquid-crystalline state. When cooling b

The large bloom-forming flagellate Gonyostomum semen has been hypothesized to be inedible to naturally occurring zooplankton due to its large cell size and ejection of long slimy threads (trichocysts) induced by physical stimulation. In a grazing experiment using radiolabelled algae and zooplankton collected from lakes with recurring blooms of G. semen and lakes that rarely experience blooms, we f

Background: Calreticulin (CRT) is a ubiquitous ER protein involved in multiple cellular processes in animals, such as protein folding and calcium homeostasis. Like in animals, plants have evolved divergent CRTs, but their physiological functions are less understood. Arabidopsis contains three CRT proteins, where the two CRTs AtCRT1a and CRT1b represent one subgroup, and AtCRT3 a divergent member.

To address the problems of climate change and energy security, Chinese government strived to develop renewable power as an important alternative of conventional electricity. In this paper, the learning curve model is employed to describe the decreasing unit investment cost due to accumulated installed capacity; the technology diffusion model is used to analyze the potential of renewable power. Com

The production of deuterons and anti-deuterons in the transverse momentum range 1.1

Treatment of sludge with enzymes has previously been shown to efficiently release organic matter. However, the added enzymes were partially adsorbed to, entrapped by or bound to the sludge structure. Simultaneous decrease of enzymes activities was observed. Reduced adsorption and more effective, lower, enzyme dose was achieved in sludge pre-treated with three cation-binding agents. The enzymatic s

We examine how the generation and propagation of high-order harmonics in a partly ionized gas medium affect their strength and synchronization. The temporal properties of the resulting attosecond pulses generated in long gas targets can be significantly influenced by macroscopic effects, in particular by the intensity in the medium and the degree of ionization which control the dispersion. Under s

Caldicellulosiruptor owensensis strain OLT (DSM 13100) is an obligately anaerobic, extreme thermophilic bacterium that is capable of utilizing a broad range of carbohydrates and producing H2 as a metabolic by-product. The performance of C. owensensis on glucose and xylose was analyzed in lab-scale bioreactors to assess its potential use in biohydrogen production. Acetate, H2, and CO2 were the main

The World Health Organization has a standardized tool to assess surgical capacity in low- and middle-income countries (LMICs), but it is often resource- and time-intensive. There currently exists no simple, evidence-based measure of surgical capacity in these settings. The proportion of cesarean deliveries in regard to the total operations (C/O ratio) has been suggested as a way to assess quickly

Popular Abstract in Swedish Reumatoid artrit (RA) även kallat ledgångsreumatism, är en ledsjukdom som innebär inflammationer i kroppens leder. Sjukdomens symptom är smärta, trötthet, nedsatt fysisk kapacitet med svullna, ömma leder. Kvinnor drabbas i större utsträckning av ledgångsreumatism än män. Sjukdomen är kronisk och behandlas med antireumatiska läkemedel samt kompletterande teambaserad behaThe overall aim of this thesis was to study how persons experience the influence of Rheumatoid Arthritis (RA) on their sexual health and their experiences of communication about sexual health, in order to improve physiotherapy within the field of rheumatology. Sexual health is an integrated part of life, and persons with Rheumatoid Arthritis, RA, often experience a decreased sexual health, which c

The three-year research project funded by MSB applies design science, in combination with traditional scientific investigation, to develop a method to guide the planning phase of capacity development projects for disaster risk reduction and climate change adaptation. The method facilitates local participation and ownership as it builds on the strengths of the Logical Framework Approach (LFA), whil

Nematode-trapping fungi are soil-living fungi that capture and kill nematodes using special hyphal structures called traps. They display a large diversity of trapping mechanisms and differ in their host preferences. To provide insights into the genetic basis for this variation, we compared the transcriptome expressed by three species of nematode-trapping fungi (Arthrobotrys oligospora, Monacrospor

Diamond-Blackfan anemia (DBA) is a congenital red cell aplasia in which 25% of the patients have a mutation in the ribosomal protein (RP) S19 gene. It is not known how the RPS19 deficiency impairs erythropoiesis and proliferation of hematopoietic progenitors. To elucidate molecular mechanisms in RPS19 deficient DBA, we analyzed the effects of RPS19 deficiency on EPO induced signal transduction, ce

Global land acquisitions, often dubbed 'land grabbing' are increasingly becoming drivers of land change. We use the tools of network science to describe the connectivity of the global acquisition system. We find that 126 countries participate in this form of global land trade. Importers are concentrated in the Global North, the emerging economies of Asia, and the Middle East, while exporters are c

In the present paper energy-consistent momentum-conserving time-stepping schemes for geometrically nonlinear multiplicative elasto-plasto-dynamics referred to as `ECMC-cG methods' are developed. In this context, the entire discretisation procedure of the global equations of motion is based on Galerkin methods in space and time, whereby special emphasis is placed on the desired conservation propert

We present a dual-focus second harmonic generation (SHG) microscopy approach based on stable, compact, and inexpensive fiber technology. One-tenth of the fiber laser output is coupled into a 100 m (=500 ns) long single-mode fiber and further amplified to achieve two separately guided beams with time-alternating pulse trains. SHG detection is performed sequentially, generating two individual images

We report on the synthesis of non-tapered wurtzite (WZ) GaP nanowires by use of in-situ etching and the structural and optical characterization thereof. HCl was evaluated as an in-situ etchant in order to impede the onset of radial growth since the WZ crystal phase in GaP nanowires preferentially grows at relatively high growth temperatures around 600 degrees C, at which strong radial growth typic