In eukaryotes, stalled and collided ribosomes are recognized by several conserved multicomponent systems, which either block protein synthesis in situ and resolve the collision locally, or trigger a general stress response. Yeast ribosome-binding GTPases RBG1 (DRG1 in mammals) and RBG2 (DRG2) form two distinct heterodimers with TMA46 (DFRP1) and GIR2 (DFRP2), respectively, both involved in mRNA tr

The last 20 years have seen dramatic improvements in the performance of algorithms for Boolean satisfiability-so-called SAT solvers-and today conflict-driven clause learning (CDCL) solvers are routinely used in a wide range of application areas. One serious short-coming of CDCL, however, is that the underlying method of reasoning is quite weak. A tantalizing solution is to instead use stronger pse

With the full-scale colonization of Hokkaido, home to the indigenous Ainu people, by the Japanese Meiji government (1868-1912), unprecedented ethnographic opportunities emerged for Western scientists and adventure-seekers. Literally dozens of such individuals “discovered” information about the Ainu and their homeland during this period, introducing European and American audiences to the subject th

Membrane proteins are challenging to study due the necessity to maintain a lipid-like environment to preserve their structure and function. Particularly difficult to study are membrane-bound enzymes that interact with lipophilic substrates. The aim of this doctoral thesis was to investigate the mechanism of action and inhibition of membrane-bound enzymes that interact with lipids and lipophilic su

Objective: The clinical significance of QT interval adaptation to heart rate changes has been poorly investigated in atrial fibrillation (AF), since QT delineation in the presence of f-waves is challenging. Therefore, the objective of the present study is to investigate new techniques for QT adaptation estimation in permanent AF. Methods: A multilead strategy based on generalized periodic componen

Flerovium (Fl, element 114) is the heaviest element chemically studied so far. To date, its interaction with gold was investigated in two gas-solid chromatography experiments, which reported two different types of interaction, however, each based on the level of a few registered atoms only. Whereas noble-gas-like properties were suggested from the first experiment, the second one pointed at a vola

C4b-binding protein (C4BP) is a multimeric glycoprotein in plasma with important regulatory functions in the complement system. It occurs in two forms, as free protein and in a non-covalent bimolecular complex with the vitamin K-dependent protein S. Protein S is an important anticoagulant and enhances the rate of inactivation by activated protein C of blood coagulation factors, Va and VIIIa. Prote

En genomgång av fiktiva språk, syldaviska, borduriska, Arumbya, i Hergés Tintin och om språkens rötter i den belgiska dialekten marolliska.

The incredible thing with blood stem cells, also known as hematopoietic stem cells (HSC), is that they can restore normal hematopoiesis in patients that need a new blood system. Since a prerequisite for successful transplantation is immune compatibility, it requires large donor registries to find a suitable match for a recipient. Unfortunately, there is still a shortage of immune-compatible donors

The electoral success of radical right parties throughout Western Europe is the biggest change to these formerly stable party systems. Several studies have identified that mainstream parties can shape the trajectory of radical right parties. Our aim is to contribute to this literature, and to investigate if and how radical right parties gain from mainstream party recognition. Theoretically, we dra