Drug repurposing is the use of a given therapeutic agent for indications other than that for which it was originally designed or intended. The concept is appealing because of potentially lower development costs and shorter timelines than are needed to produce a new drug. To date, drug repurposing for cardiovascular indications has been opportunistic and driven by knowledge of disease mechanisms or

In mudflats, interactions and transfers of nutrients and secondary metabolites may drive ecosystems and biodiversity. Foraminifera have complex trophic strategies as they often rely on bacteria and eukaryotes or on potential symbionts for carbon and nitrogen resources. The capacity of these protists to use a wide range of adaptive mechanisms requires clarifying the relationships between them and t

The levelized cost of energy (LCoE) is an important measure to quantify the macro-economic efficiency of an offshore wind farm and to enable a quantitative comparison with other types of energy production. The costs of the structural integrity management - which is required to ensure an adequate lifetime reliability of the turbine support structures - are part of the operational expenditures of an

The number of people who live in bushfire-prone areas around the world is growing. In Australia, in the states of Victoria and New South Wales, over 1.5 million people live in areas rated as high to extreme bushfire risk in (SGS Economics and Planning 2019). As effects of climate change increase the size and severity of bushfires, and a greater number of people move into these at-risk areas, there

For more than a century, the origin and evolution of the arthropod head and brain have eluded a unifying rationale reconciling divergent morphologies and phylogenetic relationships. Here, clarification is provided by the fossilized nervous system of the lower Cambrian lobopodian Cardiodictyon catenulum, which reveals an unsegmented head and brain comprising three cephalic domains, distinct from th

Background: Although many people infected with SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) experience no or mild symptoms, some individuals can develop severe illness and may die, particularly older people and those with underlying medical problems. Providing evidence-based interventions to prevent SARS-CoV-2 infection has become more urgent with the spread of more infectious SARS

On March 18, 2019, Safar (a pseudonym) was on an airplane heading to Istanbul in search of new adventures. The evening flight from Tashkent to Istanbul on Uzbekistan Airways took just under six hours.

According to the 2021 Rule of Law Index, one of the leading global indicators on the rule of law published annually by the World Justice Project, Russia and Turkey ranked 101st and 117th, respectively, among 139 countries (WJP. Rule of Law Index 2021 [online]. https://worldjusticeproject.org/our-work/research-and-data/wjp-rule-law-index-2021, 2021). The low positions of these two countries in the

Complement C3 was originally regarded as a serum effector protein, although recent data has emerged suggesting that intracellular C3 can also regulate basic cellular processes. Despite the growing interest in intracellular C3 functions, the mechanism behind its generation has not been demonstrated. In this study we show that C3 can be expressed from an alternative translational start site, resulti

Global political developments, economic growth and trade liberalization since the 1980s have changed the political and economic landscapes of most regions in the world. First, the collapse of the Soviet Union (and the communist regimes in Central and Eastern Europe) lead to the movement of large segments of populations. For example, the dissolution of the Soviet Union alone left tens of millions o

New conodont and stable isotope data are presented from the classical Baizitian section in the Yanbian County of Sichuan Province, South China. The Telychian to Sheinwoodian strata were sampled and studied for carbon isotope stratigraphy and conodont biostratigraphy. The paired δ13Ccarb and δ13Corg data reveal a pronounced positive excursion, the Manitowoc carbon isotope excursion (Manitowoc CIE,

Traditional fire alarms emit a high-frequency sound to alert the occupants of an imminent threat, which may be less appropriate for people who are deaf or hard of hearing. To address this issue, the scientific literature concerning alternative alarm technologies has been reviewed to evaluate their effectiveness in awakening people who are deaf or hard of hearing. The results show that low-frequenc

The tourism sector declared a climate emergency in 2020. It is against this background that this Curated Collection on Climate Change and Tourism is launched. A bibliometric analysis of 1290 articles reviews the 35-year development of climate change and tourism scholarship, including major research themes, key knowledge gaps, and our capacity to deliver the enormous knowledge requirements for an e

Morphology and facet engineering have been proved efficient strategies to prepare high-performance photoelectrochemical (PEC) materials. WO3/BiVO4 heterojunction photoanodes with different morphologies were prepared by simply controlling the amount of electrodeposited charge. The coral-like WO3/BiVO4 photoanode with the orientation growth of {110} and {011} active facets of BiVO4 exhibited the opt

Background: Hosts are often simultaneously infected with several parasite species. These co-infections can lead to within-host interactions of parasites, including mutualism and competition, which may affect both virulence and transmission. Birds are frequently co-infected with different haemosporidian parasites, but very little is known about if and how these parasites interact in natural host po

Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery.

OBJECTIVES: Sequential Organ Failure Assessment score is the basis of the Sepsis-3 criteria and requires arterial blood gas analysis to assess respiratory function. Peripheral oxygen saturation is a noninvasive alternative but is not included in neither Sequential Organ Failure Assessment score nor Sepsis-3. We aimed to assess the association between worst peripheral oxygen saturation during onset

From the reaction of 2-hydroxy-6-methylpyridine (L) with iron(ii) tetrafluoroborate, a new mononuclear iron(iii) octahedral complex [FeL6](BF4)3 has been isolated. The color of the complex reversibly changed from red at room temperature to yellow-orange at the liquid nitrogen temperature. Magnetization measurements indicate that iron(iii) in [FeL6](BF4)3 is in a high-spin state S = 5/2, from room