Det svenska e-infrastrukturlandskapet är fragmenterat och trots rekommendationer från beslutsfattare så ökar fragmenteringen. De nationella aktörer som har uppdrag och/eller mandat som rör forskningsdata är främst SNIC, SND, och Sunet. Dessa aktörer tillhandahåller tjänster och stöd till forskare under olika delar av forskningsdatalivscykeln. På grund av de oklara mandat och uppdrag som råder nati

In this investigation we show that the entropy of the two-dimensional infinite-state Potts model is linear in configurational energy in the thermodynamic limit. This is a direct consequence of the local convexity of the microcanonical entropy, associated with a finite system undergoing a first-order transition. For a sufficiently large number of states q, this convexity spans the entire energy ran

LukGH (LukAB) is a potent leukocidin of Staphylococcus aureus that lyses human phagocytic cells and is thought to contribute to immune evasion. Unlike the other bi-component leukocidins of S. aureus, LukGH forms a heterodimer before binding to its receptor, CD11b expressed on professional phagocytic cells, and displays significant sequence variation. We employed a high diversity human IgG1 library

The tRNA glycylation system is amongst the most complex aminoacylation systems since neither the oligomeric structure of the enzymes nor the discriminator base in tRNAs are conserved in the phylae. To understand better this structural diversity and its functional consequences, the prokaryotic glycylation system from Thermus thermophilus, an extreme thermophile, was investigated and its structural

Objectives: SSc-associated pulmonary arterial hypertension (SSc-APAH) is a late but devastating complication of SSc. Early identification of SSc-APAH may improve survival. We examined the role of circulating miRNAs in SSc-APAH. Methods: Using quantitative RT-PCR the abundance of mature miRNAs in plasma was determined in 85 female patients with ACA-positive lcSSc. Twenty-two of the patients had SSc

Boken är en översiktlig genomgång och analys av den antika världens sju underverk, med utblick mot liknande fenomen i modern tid.

The narrative of the Western modernity is a story about technological progress where technology gradually has replaced humans in the world of work. Yet, the relationship between technology and humans is more complex than that. This is illustrated by Jeff Bezos’ idea of “Artificial Artificial Intelligence,” where humans are hired as stand-ins when automatized systems fail. Much has been said about The narrative of the Western modernity is a story about technological progress where technology gradually has replaced humans in the world of work. Yet, the relationship between technology and humans is more complex than that. This is illustrated by Jeff Bezos’ idea of “Artificial Artificial Intelligence,” where humans are hired as stand-ins when automatized systems fail. Much has been said about

We have earlier shown that radio frequency electromagnetic fields can cause significant leakage of albumin through the blood-brain barrier of exposed rats as compared to non-exposed rats, and also significant neuronal damage in rat brains several weeks after a 2 h exposure to a mobile phone, at 915 MHz with a global system for mobile communications (GSM) frequency modulation, at whole-body specifi

The environment in which biology exists has dramatically changed during the last decades. Life was formed during billions of years, exposed to, and shaped by the original physical forces such as gravitation, cosmic irradiation and the terrestrial magnetism. The existing organisms are created to function in harmony with these forces. However, in the late 19th century mankind introduced the use of e

Ribonucleotide reductases catalyze the reduction of ribonucleotides to deoxyribonucleotides. Three classes have been identified, all using free- radical chemistry but based on different cofactors. Classes I and II have been shown to be evolutionarily related, whereas the origin of anaerobic class III has remained elusive. The structure of a class III enzyme suggests a common origin for the three c

In recent years, because the cloud can provide huge advantages regarding storage and computing resources, industry has been motivated to move industrial control systems to the cloud. However, the cloud also introduces major security challenges, since moving control systems to the cloud can enable attackers to infiltrate the system and establish an attack that can lead to damages and disruptions wi

The existing information supports the use of this material as described in this safety assessment. Octyl isobutyrate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog hexyl isobutyrate (CAS # 2349-07-7) show that octyl isobutyrate is

In the second episode of the second season Nic and Rebecca invite Diane Feuillet to the microphone. Diane is a researcher here at Lund Observatory working on galactic archaeology using stellar abundances, ages and kinematics. In this second season of the Meridian we are also bringing you some field reporting from the Nordic Optical Telescope on La Palma, where a team of astronomers are trying to c

Diffusion is a reoccurring phenomena in many fields and is affected by the geometry in which it takes place. Here we investigate the effects of geometry on diffusion in a Brick and Mortar model system. The tortuous effects are evaluated based on generalized Fick's law, i.e. diffusion driven by differences in chemical potential. The presented formalism gives a general (semi-) exact analytic express

Acetylated, propionylated and butyrylated rice and quinoa starches at different levels of modification and starch concentrations, were used to stabilize oil-in-water starch Pickering emulsions at 10% oil fraction. Short-chain fatty acid modified starch Pickering emulsions (SPEs) were characterized after emulsification and after 50 days of storage. The particle size distribution, microstructure, em

The purpose of this proof-of-concept study was to develop three-dimensional patient-specific mechanobiological knee joint models to simulate alterations in the fixed charged density (FCD) around cartilage lesions during the stance phase of the walking gait. Two patients with anterior cruciate ligament (ACL) reconstructed knees were imaged at 1 and 3 years after surgery. The magnetic resonance imag

The bi-component leukocidins of Staphylococcus aureus are important virulence factors that lyse human phagocytic cells and contribute to immune evasion. The γ-hemolysins (HlgAB and HlgCB) and Panton-Valentine leukocidin (PVL or LukSF) were shown to assemble from soluble subunits into membrane-bound oligomers on the surface of target cells, creating barrel-like pore structures that lead to cell lys

Reconstitution of the tyrosyl radical in ribonucleotide reductase protein R2 requires oxidation of a diferrous site by oxygen. The reaction involves one externally supplied electron in addition to the three electrons provided by oxidation of the Tyr-122 side chain and formation of the μ-oxo- bridged diferric site. Reconstitution of R2 protein Y122F, lacking the internal pathway involving Tyr-122,

Adopting a human rights-based approach to examining law, policy and practice relating to displacement in the context of disasters and climate change highlights gaps between international and national standards, and realities on the ground.