Non-steroidal anti-inflammatory drugs (NSAIDs) and other eicosanoid pathway modifiers are among the most ubiquitously used medications in the general population. Their broad anti-inflammatory, antipyretic, and analgesic effects are applied against symptoms of respiratory infections, including SARS-CoV-2, as well as in other acute and chronic inflammatory diseases that often coexist with allergy an

In this third episode of the podcast Nic and Rebecca invite Jens Hoeijmakers to the mic and chat to him about ultra-hot Jupiters and their atmospheres. Thereafter they take a closer look at a comet, which is named after the its two discoverers: Michel Giacobini and Ernst Zinner.

In this fourth episode of the podcast Nic and Rebecca invited Laura Hrastar to the mic and chatted with her about life and work at Max IV - which is a Swedish national laboratory producing brilliant synchrotron radiation for various research projects . Thereafter they take a closer look at the galaxy listed as the 31st object in the Messier Catalogue.

X-ray fluorescence microscopy performed at nanofocusing synchrotron beamlines produces quantitative elemental distribution maps at unprecedented resolution (down to a few tens of nanometres), at the expense of relatively long measuring times and high absorbed doses. In this work, a method was implemented in which fast low-dose in-line holography was used to produce quantitative electron density ma

We revisit the hypothesis that a Weberian bureaucracy enhances economic growth. Theoretically, we develop arguments for why such a bureaucracy may enhance growth and discuss plausible counterarguments. Empirically, we use new measures capturing various Weberian features in countries across the world, with some time series extending back to 1789. The evidence base from previous large-N studies is s

The S-adenosyl-L-methionine (SAM)-dependent methyltransferases attach a methyl group to the deprotonated methyl lysine (Kme0) using SAM as a donor. An intriguing, yet unanswered, question is how the deprotonation of the methyl lysine takes place which results in a lone pair of electrons at the Nϵ atom of the methyl lysine for the following methyl transfer. PRDM9, one of the few methyltransferases

High-resolution O 1s resonant inelastic x-ray scattering spectra of liquid H2O, D2O, and HDO, obtained by excitation near the preedge resonance show, in the elastic line region, well-separated multiple vibrational structures corresponding to the internal OH stretch vibration in the ground state of water. The energy of the first-order vibrational excitation is strongly blueshifted with respect to t

Palaearctic steppes evolved under the Cenozoic cold arid climate and megaherbivore pressure. A large portion of the biome persisted into the Holocene but has recently been subjected to human land use alternation. Pseudophilotes bavius (Lepidoptera: Lycaenidae) is a steppe specialist sporadically distributed in Eastern Europe and Pontic-Caspian region (from Transylvania to Southern Urals), the Balk

Agents that trigger cell differentiation are highly efficacious in treating certain cancers, but such approaches are not generally effective in most malignancies. Compounds such as DMSO and hexamethylene bisacetamide (HMBA) have been used to induce differentiation in experimental systems, but their mechanisms of action and potential range of uses on that basis have not been developed. Here, we sho

October is coming to an end as we release this sixth and last episode of the first season (not to worry, we are already planning a second season). This time Nic and Rebecca have invited Paul McMillan to the mic and chat with him about our galaxy, the Milky Way, and his involvement in ESA's Gaia satellite . Thereafter they take a closer look at the Pleiades.

In this very special solstice episode of The Meridian Nic and Rebecca look back at some of the highlights of 2021. With the days growing ever longer here in the Northern Hemisphere they have rallied a troupe of PhD students to compete in the 2021 Astronomy Games! Nic is joined by Alvaro and Johan on his team and Rebecca has convinced Daniel and Madeleine to join her team. The Games were recorded i

This work presents an analysis of the observed trends in extreme precipitation events in the Paraná River basin (PRB) from 1977 to 2016 (40 yr) based on daily records from 853 stations. The Mann–Kendall test and inverse-distance-weighted interpolation were applied to annual and seasonal precipitation and also for four extreme precipitation indices. The results show that the negative trends (signif

A continuous integrated bioprocess available from the earliest stages of process development allows for an easier, more efficient and faster development and characterization of an integrated process as well as production of small-scale drug candidates. The process presented in this article is a proof-of-concept of a continuous end-to-end monoclonal antibody production platform at a very small scal

The elliptic flow (v2) of (anti-)3He is measured in Pb–Pb collisions at sNN=5.02TeV in the transverse-momentum (pT) range of 2–6 GeV/c for the centrality classes 0–20%, 20–40%, and 40–60% using the event-plane method. This measurement is compared to that of pions, kaons, and protons at the same center-of-mass energy. A clear mass ordering is observed at low pT, as expected from relativistic hydrod

Objective: The aim of this systematic review and meta-analysis (SR-MA) was to identify signaling molecule profiles and blood-derived biomarkers in migraine and cluster headache (CH) patients. Background: Currently no migraine and CH valid biomarkers are available. Blood tests based on biomarker profiles have been used to gather information about the nervous system. Such tests have not yet been est

BACKGROUND: Malignant pleural mesothelioma (MPM) is a disease mostly confined to the thoracic cavity. Untreated, the median survival is

Cytoreductive surgery combined with intraoperative hyperthermic intrathoracic chemotherapy (HITHOC) is studied in a phase I study in the treatment of malignant pleural mesothelioma and pleural thymoma. We studied the pharmacokinetics of doxorubicin and cisplatin used during the HITHOC procedure. Furthermore, the penetration characteristics of doxorubicin were examined. Between 1998 and 2001, 24 pe

Background: Tumor ablation is often employed for unresectable colorectal liver metastases. However, no survival benefit has ever been demonstrated in prospective randomized studies. Here, we investigate the long-term benefits of such an aggressive approach. Methods: In this randomized phase II trial, 119 patients with unresectable colorectal liver metastases (n < 10 and no extrahepatic disease) re

Background CytoReductive Surgery and Hyperthermic IntraPEritoneal Chemotherapy (CRS-HIPEC) is now the preferred treatment of many peritoneal surface malignancies. In this retrospective study we aimed to analyze how several performance indicators changed during the first 100 CRS-HIPEC procedures in hospitals which recently introduced this treatment, and compare those with an experienced institution