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Interobserver agreement for neonatal seizure detection using multichannel EEG

Objective: To determine the interobserver agreement (IOA) of neonatal seizure detection using the gold standard of conventional, multichannel EEG. Methods: A cohort of full-term neonates at risk of acute encephalopathy was included in this prospective study. The EEG recordings of these neonates were independently reviewed for seizures by three international experts. The IOA was estimated using sta

Influence of gender on assessments of disease activity and function in early rheumatoid arthritis in relation to radiographic joint damage

Objective: To evaluate gender differences in score on 28-joint Disease Activity Score (DAS28), Health Assessment Questionnaire (HAQ) and Signals Of Functional Impairment (SOFI) and to relate these scores to radiographic joint destruction. Methods: In all, 549 patients with early RA (62% women) from the BARFOT (for "Better Anti-Rheumatic FarmacOTherapy'') study were included. At baseline, 1, 2 and

Operation for nitritation of sludge liquor in a full-scale SBR.

At Sjölunda WWTP, a full-scale SBR for treatment of mesophilic sludge digester liquor has been operated almost a year with stable nitrite accumulation. Only nitritation of the sludge liquor is needed since the oxidized ammonium is denitrified in the first anoxic zone of the high-loaded activated sludge in the main plant. The process strategy was to have an ammonium set-point to end the aeration, a

Bioturbation as Driver of Zooplankton Recruitment, Biodiversity and Community Composition in Aquatic Ecosystems

In an experimental study we assessed if benthic bioturbating invertebrates affect the recruitment (hatching) of zooplankton from the sediment, and if this effect persists as differences in the zooplankton community in the water column, that is, if bioturbation quantitatively stimulates benthic-pelagic coupling. We investigated the effects of four different benthic invertebrates (Asellus aquaticus,

Efficacy of strength and aerobic exercise on patient-reported outcomes and structural changes in patients with knee osteoarthritis: study protocol for a randomized controlled trial

Background: Despite an extensive literature on treatment interventions for patients with knee osteoarthritis, studies comparing the efficacy of different exercise interventions and living the life as usual on quality of life, cartilage quality and cost-effectiveness are lacking. The aim of the present study is to compare the efficacy of two different exercise programs compared to a control group i

Post-Prandial Plasma Glucose Prediction in Type I Diabetes Based on Impulse Response Models

In this paper the impact of different meals and rapid insulin were estimated as Finite Impulse Response Models from a data set of 18 patients. Based on these models short-term individualized predictors were tested for 20 and 60 minute prediction. The predictors were evaluated using Clarke Grid Analysis and had on average more than 94 % and 75 % in the A zone and less than 1 % and 3 % in the erroro

Drosophila Avoids Parasitoids by Sensing Their Semiochemicals via a Dedicated Olfactory Circuit.

Detecting danger is one of the foremost tasks for a neural system. Larval parasitoids constitute clear danger to Drosophila, as up to 80% of fly larvae become parasitized in nature. We show that Drosophila melanogaster larvae and adults avoid sites smelling of the main parasitoid enemies, Leptopilina wasps. This avoidance is mediated via a highly specific olfactory sensory neuron (OSN) type. While

Historical origins of cultural supply in Italy

I investigate the consequences of long-run persistence of a society's preferences for cultural goods. Historical cultural activity is approximated with the frequency of births of music composers during the Renaissance and is linked with contemporary measures of cultural activity in Italian provinces. Areas with a 1% higher number of composer births nowadays show an up to 0.29% higher supply of cla

Health, balance, and walking as correlates of climbing steps

The aim of this study was to investigate walking and health among woman age 75 yr or older, in the associations between the highest step up performed without support by an individual and balance, walking, and health among women age 75+. Records of the highest step, balance, walking, and health were made for 307 women age 75-93 yr living in the community. Eighty percent managed to climb steps highe

JC viral loads in patients with Crohn's disease treated with immunosuppression: can we screen for elevated risk of progressive multifocal leukoencephalopathy?

Background and aims: Anti-alpha 4 integrin therapy with natalizumab is efficacious in refractory Crohn's disease and in multiple sclerosis, but carries an estimated 1/1000 risk of progressive multifocal leukoencephalopathy (PML) caused by reactivation of latent JC virus infection. Athough anti-alpha 4 integrin therapies are likely to be introduced in the clinic, screening for the risk of PML has n

Enantiomeric Derivatives of Tokinolide B: Absolute Configuration and Biological Properties

The enantiomeric lactams (-)-8, (+)-8, (+)-9, and (-)-9 were formed by the reaction of the dimeric phthalide rac-tokinolide B (rac-3) with (R)-(+)-alpha-methylbenzylamine and (S)-(-)-alpha-methylbenzylamine. The absolute configurations of compounds 8 and 9 were assigned by experimental and theoretically calculated electronic circular dichroism methods for (+)-8 and (-)-9. Compounds 3, 5, (-)-8, (+

Thinning effects on pine-spruce forest transpiration in central Sweden

This study analyses the effects of thinning on stand transpiration in a typical mixed spruce and pine forest in the southern boreal zone. Studies of transpiration are important for models of water, energy and carbon exchange, and forest management, like thinning, would change those processes. Tree transpiration was measured by the tissue heat-balance sapflow technique, on a reference plot and a th

beta-Adrenoceptor activation depresses brain inflammation and is neuroprotective in lipopolysaccharide-induced sensitization to oxygen-glucose deprivation in organotypic hippocampal slices

Background: Inflammation acting in synergy with brain ischemia aggravates perinatal ischemic brain damage. The sensitizing effect of pro-inflammatory exposure prior to hypoxia is dependent on signaling by TNF-alpha through TNF receptor (TNFR) 1. Adrenoceptor (AR) activation is known to modulate the immune response and synaptic transmission. The possible protective effect of (alpha) over tilde and

Latent Autoimmune Diabetes in Adults Differs Genetically From Classical Type 1 Diabetes Diagnosed After the Age of 35 Years

OBJECTIVE- We studied differences between patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes, and classical type 1 diabetes diagnosed after age 35 years. RESEARCH DESIGN AND METHODS- Polymorphisms in HLA-DQB1, INS, PTPN22, and CTLA4 were genotyped in patients with LADA (n = 213), type 1 diabetes diagnosed at >35 years of age (T1D(>35y); n = 257) or 35y) and type 2 diabetic

On the performance of iterative receivers for interfering MIMO-OFDM systems in measured channels

This paper investigates the gains harvested through base station cooperation in the up-link for a multi-user (MU) Multiple-Input Multiple-Output Orthogonal Frequency Division Multiplexing (MIMO-OFDM) system, operating in a real indoor environment. The base stations perform joint detection using an iterative receiver that carries out multi-user detection and channel estimation via soft information