PURPOSE: The partial volume effect (PVE) is an important source of bias in brain perfusion measurements. The impact of tissue PVEs in perfusion measurements with dynamic susceptibility contrast MRI (DSC-MRI) has not yet been well established. The purpose of this study was to suggest a partial volume correction (PVC) approach for DSC-MRI and to study how PVC affects DSC-MRI perfusion results.METHOD

In this paper we present a two-dimensional framework for analysis of research on standards and standardization and its implications for strategic management. Existing research is organized and analyzed, demonstrating that despite the multifaceted nature of the field, patterns and logics are exposed by applying the suggested theoretical framework - its two analytical dimensions being the level of a

Protein self-assembly is extensively used in nature to build functional biomolecules and provides a general approach to design molecular complexes with many intriguing applications. Although computational design of protein-protein interfaces remains difficult, much progress has recently been made in de novo design of protein assemblies with cyclic, helical, cubic, internal and lattice symmetries.

This paper analyzes how the influence of firm-level innovation determinants varies over the industry life cycle. Two sets of determinants are distinguished: (1) determinants of a firm's innovation propensity, i.e. the likelihood of being innovative and (2) determinants of its innovation intensity, i.e. innovation sales. By combining the literature emphasizing firms' internal resources (micro-level

With the triumph of the codex, medieval literature became more deeply hermeneutic in character. A vast range of texts, in various languages and genres, were not only copied with the commentaries and glosses of ancient tradition, but also underwent continuous reworking and transformation. Indeed, the very act of transcribing texts into a manuscript was often an incentive to rewrite them. This pract

In the present work, effects of loading scheme and strain reversal on structure evolution are studied by using high pressure torsion (HPT) and twist extrusion (TE) techniques. High purity aluminum (99.99%) was processed at room temperature up to a total average equivalent strain of ∼4.8 by TE and HPT with two deformation modes: monotonic and reversal deformation with a step of 12° rotation. It was

Ecosystem-based approaches for climate change adaptation are promoted at international, national, and local levels by both scholars and practitioners. However, local planning practices that support these approaches are scattered, and measures are neither systematically implemented nor comprehensively reviewed. Against this background, this paper advances the operationalization of ecosystem-based a

Background: Alcohol use disorder (AUD) is a classic multifactorial syndrome and it is critical to understand the diversity of the relevant risk factors and how they inter-relate over development. Method: We examined 21 risk factors for AUD in four developmental tiers reflecting (i) birth, (ii) childhood and early adolescence, (iii) late adolescence, and (iv) early adulthood in 47 414 Swedish men o

One stream of research states that closed innovation and knowledge concealing is imperative for firms seeking to profit from innovation. Another stream of research states that firms can enhance innovation outcomes by means of openness and the selective revealing of knowledge. To contrast these two streams of research, we offer a comparative analysis of under what conditions firms should conceal or

PurposeThe main purpose of this study is to investigate perceptions about and contributing activities to business-to-business (B2B) brand value by corporate managers and local stakeholders in the context of emerging markets.Design/methodology/approachThe case study examines brand strategies of a multinational company in the high-tech industry. By using NVIVO, this research analyses the brand narra

Purpose The AGO-OVAR 2.29/ENGOT-ov14/PENELOPE prospectively randomized phase III trial evaluated the addition of pertuzumab to chemotherapy in patients with platinum-resistant ovarian carcinoma with low tumor human epidermal growth factor receptor 3 (HER3)mRNA expression. We report the results of the primary efficacy analysis. Patients and Methods Eligible patients had ovarian carcinoma that progr

Let (Formula presented.) be a bounded, simply connected ℂ-convex domain. Let α ∈ ℤ+ n and let f be a function on Ω which is separately (Formula presented.) -smooth with respect to zj (by which we mean jointly (Formula presented.) -smooth with respect to Rezj, Imzj). If f is α-analytic on Ω\f−1(0), then f is α-analytic on Ω. The result is well-known for the case αi = 1, 1 ⩽ i ⩽ n, even when f a pri

The effect of Ca++, Mg++, K+ and SO=4, and of serum, on the activity of testis hyaluronidase in a carbonic acid-bicarbonate buffer with pH 7.4 was investigated with the turbidimetric method. The ions were added in amounts corresponding to the serum concentration of the ion in question.The turbidity of hyaluronic acid was not modified by the investigated ions nor by serum up to 0.10 ml.The hyaluron