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Combined cell-based therapy strategies for the treatment of Parkinson's disease : Focus on mesenchymal stromal cells

Parkinson's disease is a neurodegenerative condition characterized by motor impairments caused by the selective loss of dopaminergic neurons in the substantia nigra. Levodopa is an effective and well-Tolerated dopamine replacement agent. However, levodopa provides only symptomatic improvements, without affecting the underlying pathology, and is associated with side effects after long-Term use. Cel

Microglial angiotensin type 2 receptors mediate sex-specific expression of inflammatory cytokines independently of circulating estrogen

There are sex differences in microglia, which can maintain sex-related gene expression and functional differences in the absence of circulating sex steroids. The angiotensin type 2 (AT2) receptors mediate anti-inflammatory actions in different tissues, including brain. In mice, we performed RT-PCR analysis of microglia isolated from adult brains and RNA scope in situ hybridization from males, fema

Prostaglandin EP2 Receptors Mediate Mesenchymal Stromal Cell-Neuroprotective Effects on Dopaminergic Neurons

Mesenchymal stromal cells (MSCs) have been shown to have useful properties for cell therapy and have been proposed for treatment of neurodegenerative diseases, including Parkinson’s disease. However, the mechanisms involved in recovering dopaminergic neurons are not clear. The present study aims to evaluate the pathways and molecules involved in the neuroprotective effect of MSCs. We analyzed the

School principals' proposals for preventive actions to improve mental health

BACKGROUND: School principals face a demanding work situation that puts them at risk for stress-related poor mental health. Ideally, preventive actions should be based on knowledge about the underlying notions that motivate action. However, knowledge about prevention areas and suitable initiatives for school principals is scarce or lacking, leaving key stakeholders without the overview necessary f

Nrf2 activation and downstream effects : Focus on parkinson’s disease and brain angiotensin

Reactive oxygen species (ROS) are signalling molecules used to regulate cellular metabolism and homeostasis. However, excessive ROS production causes oxidative stress, one of the main mechanisms associated with the origin and progression of neurodegenerative disorders such as Parkinson’s disease. NRF2 (Nuclear Factor-Erythroid 2 Like 2) is a transcription factor that or-chestrates the cellular res

Dopamine regulates adult neurogenesis in the ventricular-subventricular zone via dopamine D3 angiotensin type 2 receptor interactions

Adult neurogenesis is a dynamic and highly regulated process, and different studies suggest that dopamine modulates ventricular-subventricular zone (V-SVZ) neurogenesis. However, the specific role of dopamine and the mechanisms/factors underlying its effects on physiological and pathological conditions such as Parkinson's disease (PD) are not fully understood. Recent studies have described counter

Kind of Folk VOL 5 - Poland : concert with Groupa

Groupa started the new project 'Kind of Folk VOL 5 - Poland'. A collaboration with polish musicians: Grzech Piotrowski - sax, Marta Matuszna - vocalsThis day there was a concert at the Skansen museum nearby Olsztyn.

Dose-dependent effect of mesenchymal stromal cells co-grafted with dopaminergic neurons in a Parkinson's disease rat model

A major limiting factor for cell therapy in Parkinson's disease is the poor survival and reinnervation capacity of grafted dopaminergic neurons, independently of the cell source. Mesenchymal stromal cells (MSCs) have high capability to regulate the local environment through the release of trophic, antiapoptotic and immunomodulatory factors. In this work, we investigated whether co-grafting of MSCs

Posttraumatic stress disorder and its cross-generational familial relationship with drug use disorder and alcohol use disorder : an extended Swedish adoption study

Objective: Information on how parental risk for posttraumatic stress disorder (PTSD) relates to their children’s risk for drug use disorder (DUD) and alcohol use disorder (AUD) is limited. This study is the first to utilize an extended adoption design which can address questions about the degree of, and sources of, cross-generational and cross-disorder transmission of PTSD and substance use disord

Angiotensin II induces oxidative stress and upregulates neuroprotective signaling from the NRF2 and KLF9 pathway in dopaminergic cells

Nuclear factor-E2-related factor 2 (NRF2) is a transcription factor that activates the antioxidant cellular defense in response to oxidative stress, leading to neuroprotective effects in Parkinson's disease (PD) models. We have previously shown that Angiotensin II (AngII) induces an increase in reactive oxygen species (ROS) via AngII receptor type 1 and NADPH oxidase (NOX), which may activate the

Data on the effect of Angiotensin II and 6-hydroxydopamine on reactive oxygen species production, antioxidant gene expression and viability of different neuronal cell lines

This article describes the effect of the oxidative stress inducers Angiotensin II and 6-hydroxydopamine (6-OHDA) on different cell lines. The levels of expression Angiotensin type 1 and type 2 receptors in different dopaminergic cell lines are shown. The data indicate that treatment with Angiotensin II and 6-OHDA increases the production of reactive oxygen species (ROS) and decreases cell viabilit

Dynamic User Grouping based on Location and Heading in 5G NR Systems

User grouping based on geographic location in the fifth generation (5G) New Radio (NR) systems has several applications that can significantly improve network performance, user experience, and service delivery. We demonstrate how Sounding Reference Signals channel fingerprints can be used for dynamic user grouping in a 5G NR commercial deployment based on outdoor positions and heading direction emUser grouping based on geographic location in fifth generation (5G) New Radio (NR) systems has several applications that can significantly improve network performance, user experience, and service delivery. We demonstrate how Sounding Reference Signals channel fingerprints can be used for dynamic user grouping in a 5G NR commercial deployment based on outdoor positions and heading direction employ

Policy insights on the migration-sustainability nexus for urban governance.

Cities typically treat migration and sustainability as separate policy domains. When migration is highlighted in the context of sustainability in urban destination areas, it is typically understood to have no, or at worst, negative impacts on sustainability. As a result, migration and migrants are commonly left out of sustainability policy and planning. Here, we present emerging evidence to refram

Avidity maturation of anti-spike IgG after vaccination in COVID-19 convalescent vs COVID-19 naïve patients

Antibodies and avidity maturation contribute to long-lasting immunity, and previous COVID-19 seems to enhance the immune response after vaccination. The aim of this study was to compare the immune response after vaccination between COVID-19 convalescents and naïve patients. Blood samples from COVID-19 convalescents and naïve patients, taken 1, 3 and 6 months after the second dose of vaccine (mRNA-

Masking Influences : A Systematic Review of Placebo Control and Masking in Psychedelic Studies

Psychedelic-assisted therapy is becoming increasingly acknowledged as an effective therapeutic intervention for various psychiatric illnesses. However, the evaluation of masking success is rarely reported in trials. The objective of the present systematic review was to evaluate placebo-control and masking in studies exploring psychedelic-assisted therapy. Nine (k = 9) studies dating between Januar

Prevention of Trafficking in Organs, Tissues, and Cells

Trafficking in human organs, cells, and tissues has long been a source of concern for health authorities and professionals, and several international ethical guidance documents and national laws have affirmed the prohibition of trade in these substances of human origin (SoHOs). However, despite considerable attention to the issue of organ trafficking, this remains a substantial and widespread prob

Numerically robust square root implementations of statistical linear regression filters and smoothers

In this article, square-root formulations of the statistical linear regression filter and smoother are developed. Crucially, the method uses QR decompositions rather than Cholesky downdates. This makes the method inherently more numerically robust than the downdate based methods, which may fail in the face of rounding errors. This increased robustness is demonstrated in an ill-conditioned problem,

Effect of Independent Component Artifact Rejection on EEG-Based Auditory Attention Decoding

Effective preprocessing of electroencephalography (EEG) data is fundamental for deriving meaningful insights. Independent component analysis (ICA) serves as an important step in this process by aiming to eliminate undesirable artifacts from EEG data. However, the decision on which and how many components to be removed remains somewhat arbitrary, despite the availability of both automatic and manua

No Conflicting Loyalties in Parents When Their Healthy Child Donates Stem Cells to a Severely Ill Sibling : An Interview Study

Background: When a potential stem cell donor to a seriously ill child is a healthy sibling below 18 years, Swedish parents have the legal right and obligation to decide on behalf of the donor child. However, there are potentially conflicting loyalties when parents have one severely ill child in need for a cure and one healthy child who will be subjected to medical procedures. This study explored p