Disadvantaged areas may prompt or force older people to relocate due to a lack of services, the presence of crime, and area unattractiveness, but knowledge in this area is insufficient. The aim was to investigate whether older adults living in different types of disadvantaged areas in Sweden were considering moving away from the area, and to explore similarities and differences in underlying resid

I civilprocessrätten är taleformerna, möjligheten att göra taleändringar och reglerna om rättskraft centrala, men de anses ofta svåröverskådliga. Här ges en översikt över rättsläget med fokus på de viktigaste frågorna. Bland annat behandlas när en prestation måste vara förfallen till fullgörelse för att en fullgörelsetalan ska kunna väckas, hur förutsättningarna för att väcka en fastställelsetalan

The efficiency of translation termination is determined by the nature of the stop codon as well as its context. In eukaryotes, recognition of the A-site stop codon and release of the polypeptide are mediated by release factors eRF1 and eRF3, respectively. Translation termination is modulated by other factors which either directly interact with release factors or bind to the E-site and modulate the

BACKGROUND: Allergic contact dermatitis (ACD) from protective gloves is often caused by rubber additives, such as accelerators. However, while accelerator-free rubber gloves are available, they still cause ACD in some individuals.OBJECTIVES: A new allergen, 2-cyаnоethyl dimethyldithiocarbamate, (CEDMC), has recently been identified in accelerator-free gloves, and we here provide a first in vitro c

The human silencing hub (HUSH) complex binds to transcripts of LINE-1 retrotransposons (L1s) and other genomic repeats, recruiting MORC2 and other effectors to remodel chromatin. How HUSH and MORC2 operate alongside DNA methylation, a central epigenetic regulator of repeat transcription, remains largely unknown. Here we interrogate this relationship in human neural progenitor cells (hNPCs), a soma

You want to run an experiment where you anticipate finding a treatment effect.How large should your sample size be to have a reasonable chance of detectingsignificant results? In this manuscript, I present and explain the Stata code I use toaddress this question. The code uses simulations to conduct power analyses,offering a flexible alternative to the commonly used analytical tools. Unliketraditi

Variations in solar activity have been proposed to play an important role in recent and past climate change. To study this link on longer timescales, it is essential to know how the Sun has varied over the past millennia. Direct observations of solar variability based on sunspot numbers are limited to the past 400 years, and beyond this we rely on records of cosmogenic radionuclides, such as 14C a

Treating severe dermal disruptions often presents significant challenges. Recent advancements have explored biological cell sprays as a promising treatment, but their success hinges on efficient cell delivery and complete wound coverage. This requires a good spray distribution with a small droplet size, high particle number, and ample surface coverage. The type of nozzle used with the spray device

In recent years, trust has emerged as a topic of interest for scholars aiming to understand the mechanisms enabling transnational intelligence cooperation and focusing on relations of trust between intelligence agencies. The potential dynamics between the trust facilitating transnational intelligence cooperation and the public trust in intelligence agencies on a national level, however, remains un

2H-NbS2 is a classic example of an anisotropic multiband superconductor, with significant recent work focusing on the interesting responses seen when high magnetic fields are applied precisely parallel to the hexagonal niobium planes. It is often contrasted with its sister compound 2H-NbSe2 because they have similar onset temperatures for superconductivity, but 2H-NbS2 has no charge density wave w

Objective: To screen a general pediatric population for type 1 diabetes (T1D), celiac disease (CD), and autoimmune thyroid disease (AITD) after home capillary sampling. Methods: Swedish schoolchildren between 6–9 years and 13–16 years of age were invited to screening by taking a capillary sample at home. Samples were returned by mail and assessed for autoantibodies associated with T1D, CD, and AIT

Motivated by the analysis of the tunneling effect for the magnetic Laplacian, we introduce an abstract framework for the spectral reduction of a self-adjoint operator to a hermitian matrix. We illustrate this framework by three applications, firstly the electro-magnetic Laplacian with constant magnetic field and three equidistant potential wells, secondly a pure constant magnetic field and Neumann

A cubic DNA nanocage probe is able to enter EVs derived from MDA-MB-231 cells and react with miRNA-10b. The probe-loaded EVs were employed to monitor the process of entry of miRNA-10b into MCF-10A cells, allowing visualization of EV-mediated intercellular communication of miRNA-10b between the cancer cells.

The ribosome is an essential drug target as many classes of clinically important antibiotics bind and inhibit its functional centers. The catalytic peptidyl transferase center (PTC) is targeted by the broadest array of inhibitors belonging to several chemical classes. One of the most abundant and clinically prevalent mechanisms of resistance to PTC-acting drugs is C8-methylation of the universally