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Genetic and Metabolic Markers for the Development of Diabetes after Gestational Diabetes Mellitus

Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING PÅ SVENSKA Graviditetsdiabetes (GDM) definieras som ett diabetestillstånd som upptäcks under graviditet. Ofta orsakas detta tillstånd av de hormonförändringar som uppträder under graviditet vilka medför en ökad insulinresistens, dvs. ett ökat motstånd mot insulinets effekter. Diagnosen GDM utesluter dock inte diabetes av annan orsak soThe aims of this work were to determine the prevalence of postpartum diabetes among women with gestational diabetes mellitus (GDM) in a prospective study 5 years postpartum; to characterize these women according to insulin secretion, insulin sensitivity, autoimmunity and genetics; and to identify possible markers and predictors for the development of manifest diabetes. The subjects were recruited

Reduced Insular Glutamine and N-Acetylaspartate in Systemic Lupus Erythematosus: A Single-Voxel H-1-MR Spectroscopy Study

Rationale and Objectives: To investigate for differences in metabolic concentrations and ratios between patients with systemic lupus erythematosus (SLE) without (group SLE) and those with neurological symptoms (group NPSLE) compared to a healthy control (group HC) in three normal-appearing brain regions: the frontal white matter, right insula (RI), and occipital gray matter and whether changes in

The current role of beta-blockers in chronic heart failure: with special emphasis on the CIBIS III trial

Beta-blockers (bisoprolol, metoprolol succinate, carvedilol, and to some extent nebivolol), given on top of angiotensin-converting enzyme (ACE) inhibitors, improve survival and reduce morbidity in symptomatic stable chronic heart failure (CHF). Early beta-blockade may help to improve survival and especially prevent sudden death, but the usual practice of starting the ACE inhibitor first may lead t

Validation of a new plasma cystatin C-based formula and the Modification of Diet in Renal Disease creatinine-based formula for determination of glomerular filtration rate

Objective. New proposed definitions of chronic kidney disease necessitate the development and use of simple and accurate methods for estimating glomerular filtration rate (GFR). Plasma cystatin C has been shown to be a more reliable GFR marker than creatinine and formulae for estimating GFR have been reported. The purpose of this study was to validate a cystatin C-based GFR prediction equation in

Typification of species of Hieracium s. stricto described by Norrlin from central Scandinavia

Twenty-six names of taxa of Hieracium sections Hieracium, Bifida and Vulgata (Asteraceae) described by the Finnish author J.P. Norrlin based on material from central Sweden and adjacent Norway and originally published in 1888 are lectotypified, and their applications are discussed. The replacement name H. cognatum T. Tyler & Sennikov is proposed as a substitute for the illegitimate H. propinqu

Polarization dependence of surface-enhanced Raman scattering in gold nanoparticle-nanowire systems

We study the polarization dependence of surface-enhanced Raman scattering (SERS) in coupled gold nanoparticle-nanowire systems. The coupling between the continuous nanowire plasmons and the localized nanoparticle plasmons results in significant field enhancements and SERS enhancements comparable to those found in nanoparticle dimer junctions. The SERS intensity is maximal when the incident light i

Probing the transient interaction between the small heat-shock protein Hsp21 and a model substrate protein using crosslinking mass spectrometry.

Small heat-shock protein chaperones are important players in the protein quality control system of the cell, because they can immediately respond to partially unfolded proteins, thereby protecting the cell from harmful aggregates. The small heat-shock proteins can form large polydisperse oligomers that are exceptionally dynamic, which is implicated in their function of protecting substrate protein

On Pressure Regulation of the Middle Ear

Popular Abstract in Swedish Mellanörats funktion är att överföra och förstärka ljudvågor från luften i hörselgången till innerörats vätska. Denna överföring är optimal när trumhinnan är i neutral position, dvs när trycket i mellanörat och omgivningen är lika. Avvikelser i mellanörats tryck ses vid kroniska mellanöresjukdomar, fr a är det visat ett samband mellan negativt tryck och sjukdomstillstånThe middle ear (ME) pressure is regulated by gas diffusion over the ME mucosa and pressure equalizations via the Eustachian tube (ET). Disturbance in the regulation of ME pressure is believed to contribute to the development of chronic ear diseases. In this work subjects with chronic central perforation (CCP), healthy ears with ventilation tubes (VTs), attic cholesteatoma (AC) and Meniere’s diseas

Candidate chiral bands in Tl-198

High-spin states in Tl-198 were studied using the Au-197(alpha, 3n) reaction. The level scheme was considerably extended including two new bands and several non-yrast levels. One of the new bands is possibly a chiral partner to the yrast pi h(9/2) circle times vi(13/2)(-1) band. Two-quasiparticle-plus-triaxial-rotor model calculations suggest an aplanar orientation of the total angular momenta for

Multiexciton Absorption Cross Sections of CdSe Quantum Dots Determined by Ultrafast Spectroscopy

Multiexciton absorption cross sections are important for analysis of a number of experiments, including multiple exciton generation and stimulated emisson. We present a rigorous method to determine these cross sections using transient absorption (TA) measurements. We apply the method to CdSe quantum dots (QDs) and core–shell (CdSe)ZnS QDs. The method involves measuring TA dynamics for various exci

Antibodies against gonadotropin-releasing hormone (GnRH) in patients with diabetes mellitus is associated with lower body weight and autonomic neuropathy.

Esophageal dysmotility and gastroparesis are common secondary complications in patients with diabetes mellitus. Patients with dysmotility express antibodies against gonadotropin-releasing hormone (GnRH) in serum. The aim of the present study was to scrutinize patients with diabetes mellitus with regard to the presence of GnRH antibodies, and to examine associations between antibodies and clinical

Vegetation and climate in the latest Oligocene-earliest Miocene in Jylland, Denmark

Two exposures in Jylland, Denmark, encompassing beds of latest Oligocene to earliest Miocene age (latest Chattian-early Aquitanian) yielded well-preserved palynofloras. The assemblages indicate that Jylland was covered by extensive Taxodiaceae swamp forests in the mid-Cenozoic. Besides a Taxodiaceae-Cupressaceae association, which was overwhelmingly dominant, other common plants in this habitat we

A Contemporary Update on Pathology Reporting for Prostate Cancer: Biopsy and Radical Prostatectomy Specimens

Context: The diagnosis of and reporting parameters for prostate cancer (PCa) have evolved over time, yet they remain key components in predicting clinical outcomes. Objective: Update pathology reporting standards for PCa. Evidence acquisition: A thorough literature review was performed for articles discussing PCa handling, grading, staging, and reporting published as of September 15, 2011. Electro

International Network for Comparison of HIV Neutralization Assays: The NeutNet Report II

Background: Neutralizing antibodies provide markers for vaccine-induced protective immunity in many viral infections. By analogy, HIV-1 neutralizing antibodies induced by immunization may well predict vaccine effectiveness. Assessment of neutralizing antibodies is therefore of primary importance, but is hampered by the fact that we do not know which assay(s) can provide measures of protective immu