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Studies on renal progenitor cells and kidney cancer
Kidney cancer and renal injuries affect millions of people in the world resulting in high patient morbidity and mortality, as well as one of the most extensive medical costs for society. Upon renal injury the kidney has an endogenous ability to repair damaged tubules and restore kidney function, provided that the patient receives adequate supportive care in time. The molecular basis for this regen
Simulation of a suite of generic long-pulse neutron instruments to optimize the time structure of the European Spallation Source
We here describe the result of simulations of 15 generic neutron instruments for the long-pulsed European Spallation Source. All instruments have been simulated for 20 different settings of the source time structure, corresponding to pulse lengths between 1 ms and 2 ms; and repetition frequencies between 10 Hz and 25 Hz. The relative change in performance with time structure is given for each inst
Increased Factor Viii Activity In Portal Vein Thrombosis And Budd-Chiari Syndrome
Policy instruments for managing road safety on EU-roads
Directive 2008/96/EC on road infrastructure safety management requires the establishment and implementation of procedures relating to road safety impact assessments (RSIA), road safety audits (RSA), ranking of high accident concentration sections and network safety ranking (NSR) and road safety inspections (RSI). The aim of this article is to present the outputs of BALTRIS project. The goal of the
Acupuncture compared with placebo acupuncture in radiotherapy-induced nausea-a randomized controlled study
It is not known if verum (real) acupuncture is effective for nausea and vomiting (emesis) during radiotherapy. We randomly treated 215 blinded cancer patients with verum: penetrating 'deqi' creating acupuncture (n = 109) or non-penetrating sham needles (n = 106) two to three times per week. The patients documented emesis daily during the radiotherapy period. Primary end point was the number of pat
The origin of polymorphic crypsis in a heterogeneous environment
ABSTRACT Polymorphic crypsis has been observed in several taxa, but has, until now, lacked a firm theoretical understanding. How does a single morph, well camouflaged in one type of habitat, evolve crypsis in another, not isolated, habitat? We here analyze a model of one prey species living in two different habitats connected by passive dispersal. We find that the rate of dispersal, the trade-off
The evolution of respiratory chain complex I from an 11-subunit last common ancestor
Perceptions of Learning among Swiss Watch Managers
Purpose – This paper aims to explore managers' perceptions of learning within a sample of Swiss watch firms. Design/methodology/approach – A purposeful (judgmental) stratified sampling method was employed, where in‐depth interviews with 13 marketing managers and owners were carried out over a three‐month period. Meaning units (MUs) were abstracted, which were compared and discussed with the inter
Mutual Exclusivity Analysis of Genetic and Epigenetic Drivers in Melanoma Identifies a Link Between p14(ARF) and RAR beta Signaling
Melanoma genomes contain thousands of alterations including: mutations, copy number alterations, structural aberrations, and methylation changes. The bulk of this variation is stochastic and functionally neutral, with only a small minority representing "drivers" that contribute to the genesis and maintenance of tumors. Drivers are often directly or inversely correlated across tumors, reflecting th
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A Genetic Mouse Model of Parkinson's Disease Shows Involuntary Movements and Increased Postsynaptic Sensitivity to Apomorphine
Alpha-synuclein (SNCA) protein aggregation plays a causal role in Parkinson's disease (PD). The SNCA protein modulates neurotransmission via the SNAP receptor (SNARE) complex assembly and presynaptic vesicle trafficking. The striatal presynaptic dopamine deficit is alleviated by treatment with levodopa (l-DOPA), but postsynaptic plastic changes induced by this treatment lead to a development of in
CO₂-cycle in cement and concrete : Part 1: Examination of a previous NIC-project - Part 2: Further literature study on mechanisms/models
Increased abdominal obesity, adverse psychosocial factors and shorter telomere length in subjects reporting early ageing; the MONICA Northern Sweden Study
Background: The rate of biological ageing is individual and represents the steady decrease in physiological and mental functions. Adverse social factors have been shown to influence this process. Self-perceived early ageing (SEA) might be a useful indicator of early biological ageing and increased mortality risk. The aim of this population-based study was to identify markers of SEA, including telo
Analyzing the Relationship between Objective-Subjective Health Status and Public Perception of Climate Change as a Human Health Risk in Coastal Tanzania
Climate change is considered as the biggest threat to human health in the 21st century. Sub-Saharan Africa, which is the most-at-risk region of the world, is estimated to have a disproportionately large share of the burden of climate change-induced environmental and human health risks. To develop effective adaptations to protect public health, it is essential to consider how individuals perceive a
Phosphorylation of ERα and HIF-1α in breast cancer with focus on tamoxifen response and links to kinase activation
Anti-oestrogens are commonly used in adjuvant breast cancer treatment and for a long time tamoxifen has been the main endocrine treatment. Patients who are eligibly for endocrine treatment are selected by the tumour-specific expression of oestrogen receptor (ER) and approximately 70 % of all breast cancer patients are classified as ER positive. However, resistance to tamoxifen is common and severa
Inverse relation between vitamin D and serum total immunoglobulin G in the Scandinavian Cystic Fibrosis Nutritional Study
Background/Objectives: The hallmark of cystic fibrosis (CF) is chronic lung inflammation. The severity of lung disease is closely correlated with immunoglobulin G (IgG) levels. Beyond its contribution to the bone health, the importance of vitamin D has not been fully recognized owing to the lack of human studies providing evidence of its benefit. In the context of the recently described immunomodu
Inotropic Support During Experimental Endotoxemic Shock: Part II. A Comparison of Levosimendan with Dobutamine
BACKGROUND: We compared the association of levosimendan or dobutamine with norepinephrine for the maintenance of systemic and hepatosplanchnic perfusion during early endotoxemic shock. METHODS: Twenty anesthetized pigs (26.8 +/- 0.5 kg) were instrumented with flow probes and catheters to monitor systemic and regional perfusion as described in our companion article in this issue of the journal. Two
Resonant photoemission spectroscopy studies of the magnetic phase transitions in Pr0.5Sr0.5MnO3
The valence band electronic structure of Pr0.5Sr0.5MnO3 has been investigated using resonant photoemission spectroscopies across its paramagnetic metallic (PMM)-ferromagnetic metallic (FMM)-antiferromagnetic insulator (AFMI) transition. Using bulk sensitive soft X-ray photoemission, we have confirmed the presence of a gap in the near Fermi level electronic spectrum in the charge ordering (CO) anti
The very long-term course of severe depression, with focus on suicidality
Abstract Objective: To study the very long-term course of severe depression and the subjects own experiences many years after a suicide attempt. Method: Patients diagnosed with severe depression/melancholia between 1956 and 1969 were interviewed 37- 53 years after index admission. Seventy-five telephone interviews were held and medical records were read in many cases. Long-term course of depressio