The study of healthy human aging is important for shedding light on the molecular mechanisms behind aging to promote well-being and to possibly predict and/or avoid the development of age-related disorders such as atherosclerosis and diabetes. Herein, we have employed an untargeted mass spectrometry-based approach to study age-related protein changes in a healthy Sicilian plasma cohort including l

Background: Cervical cancer is a public health challenge despite the available free screening service in Ethiopia. Early screening for cervical cancer significantly improves the chances of successful treatment of pre-cancers and cancers among women of reproductive age. Therefore, this study aimed to assess the uptake of screening and identify the factors among women of reproductive age. Methods: A

Activation of the kynurenine pathway (KP) has been reported in patients with pulmonary arterial hypertension (PAH) undergoing PAH therapy. We aimed to determine KP-metabolism in treatment-naïve PAH patients, investigate its prognostic values, evaluate the effect of PAH therapy on KP-metabolites and identify cytokines responsible for altered KP-metabolism. KP-metabolite levels were determined in pl

Therapeutic antibodies are transforming the treatment of cancer and autoimmune diseases. Today, a key challenge is finding antibodies against new targets. Phenotypic discovery promises to achieve this by enabling discovery of antibodies with therapeutic potential without specifying the molecular target a priori. Yet, deconvoluting the targets of phenotypically discovered antibodies remains a bottl

Responding effectively to climate change requires an understanding of what shapes people’s individual and collective sense of agency and responsibility towards the future. It also requires transforming this understanding into political engagement to support systems change. Based on a national representative survey in Sweden (N = 1,237), this research uses the novel SenseMaker methodology to look i

The European Union has a low-carbon roadmap that aims at reducing greenhouse gas emissions toprevent further climate change and achieve climate-neutrality by 2050. Many of the historical buildings that wehave today will still be around in 2050. Hence, there is a need to improve their energy performance. A way to dothis is to use hemp-lime as a material for renovation. Hemp shiv, the woody core par

In eukaryotes, iron-sulfur clusters are essential cofactors for numerous physiological processes, but these clusters are primarily biosynthesized in mitochondria. Previous studies suggest mitochondrial ABCB7-type exporters are involved in maturation of cytosolic iron-sulfur proteins. However, the molecular mechanism for how the ABCB7-type exporters participate in this process remains elusive. Here

Background: Adolescent major depressive disorder (MDD) is highly prevalent and associated with lifelong adversity. Evidence-based treatments exist, but accessible treatment alternatives are needed. We aimed to compare internet-based psychodynamic therapy (IPDT) with an established evidence-based treatment (internet-based cognitive behavioural therapy [ICBT]) for the treatment of adolescents with d

Objective Ultrasound is a promising tool to foster much-needed improvement of skin assessment in systemic sclerosis (SSc). Our aim was to develop evidence and expert opinion-based recommendations to promote the standardisation and harmonisation of technical execution and reporting of skin ultrasound studies in SSc. Methods A multidisciplinary task force of 16 members from five European countries a

Written with media students in mind, this accessible book provides both students and researchers with a new perspective on how to research engagement, not as a metric but as a marker of power relations.This book navigates the reader through a tighter analytical notion of engagement within an understanding of media, culture and democracy. Dahlgren and Hill offer a new definition of engagement as an

A Circular Economy (CE) constitutes one pathway towards realising sustainable productionand consumption. Here, the repair of broken products (compared to replacement) consti-tutes an important strategy to keep products in the economy for longer, thereby reducingwaste, as well as the need to extract resources and emit pollution in the manufacture of areplacement product. In today’s world, repair do

In 2017, the Danish parliament discussed prayer rooms at educational institutions in a broadly publicised controversy. The debate followed a series of issues arising from such institutions’ changing demography, resulting in increased Muslim presence. Beneath the public and parliamentary debate in 2017, civil servants in ministries and educational institutions became highly engaged in negotiating w

While improved catalytic properties of many surfaces covered by two-dimensional materials have been demonstrated, a detailed in situ picture of gas delivery, undercover reaction, and product removal from the confined space is lacking. Here, we demonstrate how a combination of gas pulses with varying compositions and time-resolved ambient pressure photoelectron spectroscopy can be used to obtain su

This brief puts forward three foundational principles that explain the difficulties in regulating multinational enterprises. This has implications on whether more or less coercive strategies could be pursued to ensure responsible business conduct. The task of regulating lead firms should remain mindful of fundamental considerations of corporate law (legal separation of entities), international law