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Enhanced external counter pulsation in treatment of refractory angina pectoris: two year outcome and baseline factors associated with treatment failure

Background: Enhanced external counter pulsation (EECP) is a non-invasive treatment option for patients with refractory angina pectoris ineligible to further traditional treatment. The aim of this study was to evaluate the effect of EECP on patients at a Scandinavian medical centre and to investigate if outcome can be predicted by analysing baseline factors. Methods: 86 consecutive patients (70 mal

An overview on preclinical and clinical experiences with photodynamic therapy for bladder cancer

Photodynamic therapy (PDT) is one of the most interesting methods of photo treatment. In general, PDT is a modality for the treatment of non-muscle invasive tumors. PDT is very well suited in managing bladder cancer, as the bladder is accessible by endoscopy and the tumors are most often limited to the mucosa or sub-mucosa. PDT is likely more useful for patients with recurrent tumors after convent

A novel proteomic approach reveals a role for Mg-protoporphyrin IX in response to oxidative stress

The presence of genes encoding organellar proteins in different cellular compartments necessitates a tight coordination of expression by the different genomes of the eukaryotic cell. This coordination of gene expression is achieved by organelle-to-nucleus communication. Stress-induced perturbations of the tetrapyrrole pathway trigger large changes in nuclear gene expression. In order to investigat

Biosynthesis of unusual moth pheromone components involves two different pathways in the Navel Orangeworm, Amyelois transitella

The sex pheromone of the navel orangeworm, Amyelois transitella (Walker) (Lepidoptera: Pyralidae), consists of two different types of components, one type including (11Z,13Z)-11,13-hexadecadienal (11Z,13Z-16:Ald) with a terminal functional group containing oxygen, similar to the majority of moth pheromones reported, and another type including the unusual long-chain pentaenes, (3Z,6Z,9Z,12Z,15Z)-3,

A low-power 2nd-order CT delta-sigma modulator with a single operational amplifier

We present a 2nd-order 4-bit continuous-time (CT) delta-sigma modulator (DSM) employing a 2nd-order loop filter with a single operational amplifier. This choice strongly reduces the power consumption, since operational amplifiers are the most power hungry blocks in the DSM. The DSM has been implemented in a 65 nm CMOS process, where it occupies an area of . It achieves an SNDR of 64 dB over a 500

Noncontact surface wave testing of pavements using microphones.

Pavements are constructed using several layers of materials, and their durability depends mainly on the stiffness modulus and thickness of these strata. Surface wave testing is an effective tool to measure the stiffness and thickness of pavement layers. However, measurements are still based on spot testing with fixed receivers and source. The typical large size of pavements and the cost of closing

Meta-analysis identifies six new susceptibility loci for atrial fibrillation

Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death(1). We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European anc

Contribution of various microenvironments to the daily personal exposure to ultrafine particles: Personal monitoring coupled with GPS tracking

Exposure to ultrafine particles (UFP) may have adverse health effects. Central monitoring stations do not represent the personal exposure to UFP accurately. Few studies have previously focused on personal exposure to UFP. Sixty non-smoking residents living in Copenhagen, Denmark were asked to carry a backpack equipped with a portable monitor, continuously recording particle number concentrations (

Quantification of Fat Content and Fatty Acid Composition Using Magnetic Resonance Imaging

Popular Abstract in Swedish Fetma har blivit ett växande folkhälsoproblem under de senaste decennierna och den epidemiartade utvecklingen har fått stor uppmärksamhet. Faktum är att världshälsoorganisationen WHO uppger att 1.4 miljarder människor är överviktiga och att 65 % av jordens befolkning lever i länder där fler dör av övervikt och fetma än av undervikt. Fetma är nära kopplat till hjärt- ochIn obesity and several other disease scenarios, the measurement of fat accumulation in various organs and tissues has become a sought-after technique in clinical diagnostics and research. Especially, quantitative and non-invasive techniques which also provide images of accumulated fat throughout the body would be valuable. In the typical hospital, magnetic resonance imaging (MRI) is the only techn

Selection Shapes Transcriptional Logic and Regulatory Specialization in Genetic Networks.

Living organisms need to regulate their gene expression in response to environmental signals and internal cues. This is a computational task where genes act as logic gates that connect to form transcriptional networks, which are shaped at all scales by evolution. Large-scale mutations such as gene duplications and deletions add and remove network components, whereas smaller mutations alter the con

Inflammatory mediators in diabetic retinopathy

Diabetic retinopathy (DR) is the most feared complication of diabetes with an overall prevalence of 21.9-36.8% and may, if untreated, lead to severe visual disability or blindness. DR is histologically characterized by pericyte and endothelial cell loss, formation of acellular vessel strands, micro-occlusions, progressive ischemia, and finally the appearance of neovascularization and fibrosis. Hyp

Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors

Background: The orally active quinoline-3-carboxamide tasquinimod [ABR-215050; CAS number 254964-60-8), which currently is in a phase II-clinical trial in patients against metastatic prostate cancer, exhibits anti-tumor activity via inhibition of tumor angiogenesis in human and rodent tumors. To further explore the mode of action of tasquinimod, in vitro and in vivo experiments with gene microarra

Economic consequences of accidents to hands and forearms by log splitters and circular saws: Cost of illness study

We estimated costs associated with injuries to hands from log splitters and circular saws used to cut up firewood and assessed the value of prevention. The study was carried out as a cost of illness study with an incidence approach based on 57 consecutive patients (median age 51; range 8--81) with injuries to the hand or forearm. Twenty-six of the 57 had an amputation which required microsurgery a

Tuberculosis case finding in HIV-positive adults receiving care at health centres in Ethiopia

Popular Abstract in Swedish Tuberkulos (tbc) är en av de sjukdomar som sedan tusentals år orsakat mest lidande för mänskligheten. Mycobacterium tuberculosis är den bakterie som orsakar tbc hos människor. Att vi lever tätare inpå varandra på grund av växande befolkning globalt gör att denna luftburna smitta kan fortleva. Fattigdom och undernäring är viktiga bidragande orsaker som förklarar varför dRapid, accurate diagnosis and management of TB in HIV-positive individuals is critical for the success of antiretroviral treatment programmes in primary health care in Sub-Saharan Africa. These studies aim to develop and evaluate methods for TB case finding in adults receiving care at Ethiopian health centres. The prevalence of active TB in a prospective cohort of 812 HIV-positive adults was deter

Dynamical effects in x-ray absorption spectra of graphene and monolayered h-BN on Ni(111)

We present first-principles calculations of x-ray absorption spectra of graphene and hexagonal BN monolayer on the Ni(111) substrate. Including dynamical core-hole screening effects according to the theory of Mahan-Nozieres-de Dominics (MND) results in an overall good agreement with previously published experimental data and our new observations. This approach provides a unified first-principles d

Diabetic Foot

Ulcerated diabetic foot is a complex problem. Ischaemia, neuropathy and infection are the three pathological components that lead to diabetic foot complications, and they frequently occur together as an aetiologic triad. Neuropathy and ischaemia are the initiating factors, most often together as neuroischaemia, whereas infection is mostly a consequence. The role of peripheral arterial disease in d