Cytokines and Neutrophils in the Urinary Tract Mucosa
This study investigated the urinary tract cytokine reponse to infection and the role of chemokines for neutrophil recruitment to the urinary tract. The results suggest that 1) IL-8 and TGFb are consitutively produced by uroepithelial cells in vivo, and that uroepithelial cells are stimulated to produce IL-1b and IL-6 by uropathogenic Escherichia coli. 2) MIP-2 (mouse IL-8 homologue) plays an impor