Bacterial drug resistance is a serious concern for human health. Multidrug efflux pumps export a broad variety of substrates out of the cell and thereby convey resistance to the host. In Escherichia coli, the AcrB:AcrA:TolC efflux complex forms a principal transporter for which structures of the individual component proteins have been determined in isolation. Here, we present the X-ray structure o

Fractures of the proximal part of the femur, hip fractures, are common and costly. The number of hip fractures has increased in all western countries during recent decades. This has occurred mainly because of an increase in the number of elderly people and also due to an increase in the risk for hip fracture among the oldest persons. Due to an increase in ageing population all over the world there

Background: Dietary risks today constitute the largest proportion of disability-adjusted life years (DALYs) globally and in Sweden. An increasing number of people today consume highly processed foods high in saturated fat, refined sugar and salt and low in dietary fiber, vitamins and minerals. It is important that dietary trends over time are monitored to predict changes in disease risk. Methods:

We present a model featuring heterogeneous households with a conspicuous consumptionmotive, in which inequality can decrease financial stability, and relate this behavior to the recent financial crisis in theUSA. A natural policy conclusion would be to combat income inequality jointly with financial instability by means of a progressive system of taxes and transfers. We investigate this for the ca

Seventy-nine consecutive patients, 70 patients with acoustic neurinomas (ACN) and 9 patients with cerebello-pontine angle tumours of other etiology (o-CPA) were analysed with respect to tumour size and the result of the caloric and oculomotor tests. The size of the tumour was judged by the largest diameter calculated from the computerized tomography. A highly significant linear relationship betwee

The molecular characterization of recurrent chromosome aberrations in the early 1980s laid the foundation for gene fusion detection in cancer. This approach remained the unrivalled method to identify fusion genes for a quarter of a century and led to the detection of more than 700 neoplasia-associated fusion genes. The advancement of deep sequencing in the mid-2000s revolutionized the search for c

BACKGROUND: The amount of resources, particularly prepaid resources, available for health can affect access to health care and health outcomes. Although health spending tends to increase with economic development, tremendous variation exists among health financing systems. Estimates of future spending can be beneficial for policy makers and planners, and can identify financing gaps. In this study,

BACKGROUND: An adequate amount of prepaid resources for health is important to ensure access to health services and for the pursuit of universal health coverage. Previous studies on global health financing have described the relationship between economic development and health financing. In this study, we further explore global health financing trends and examine how the sources of funds used, typ

A short peripheral intravenous catheter or cannula (PIVC) is frequently used to deliver chemotherapy in oncology practice. Although safe and easy to insert, PIVCs do fail, leading to personal discomfort for patients and adding substantially to treatment costs. As the procedure of peripheral catheterization is invasive, there is a need for greater consistency in the choice, insertion and management

Honeybees face many parasites and pathogens and consequently rely on a diverse set of individual and group-level defenses to prevent disease. The crop microbiota of Apis mellifera, composed of 13 Lactic Acid Bacterial (LAB) species within the genera Lactobacillus and Bifidobacterium, form a beneficial symbiotic relationship with each other and the honeybee to protect their niche and their host. Po

The postural control mechanisms were evaluated in 10 blinds and in 10 subjects with Usher's syndrome. The results were compared with 27 age matched healthy volunteers. In visual conditions the subjects with Usher's syndrome performed worse, but in nonvisual condition they performed equally well as the controls. The results were the same irrespective of whether the tests were performed on a rigid s

Fourteen patients with vestibular neuritis were examined at onset of symptoms and after one year. Postrotatory time constant and gain in the vestibulo-ocular reflex (VOR) were measured after rotation with a velocity step of 150 deg/s. There was no significant difference in gain towards the healthy side at onset of the disease compared to recordings after one year. The time constant towards the hea

Many subjects have a negative spike in the beginning of a saccade in electro-oculographic signals. The amplitude of the spike depends on the location of the electrodes. The spike distorts the saccades and causes errors in the parameters. The saccade spike can assist in the identification of small saccades. A syntactic technique based on formal languages and parsing is presented which looks for spi

Saccadic eye movements provide important information about the neuron system at several levels. In recent years computer analysis of saccades has been adapted for use in clinical work. The most common detection methods do not always function without the user's control and aid. In the present paper a digital filter is described for the detection of saccades. This non-recursive filter unscrambles sa

The article intends to analyze the closely correlated concepts of trademark exhaustion and parallel imports. The growing importance of these concepts in the current world, especially in the European Union, makes it an interesting research topic, even though the concepts are complicated due to their nature and different actors involved. The authors use comparative approach, concentrating on two wor