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Background: When compared to the other mismatch repair genes involved in Lynch syndrome, the identification of mutations within PMS2 has been limited (<2% of all identified mutations), yet the immunohistochemical analysis of tumour samples indicates that approximately 5% of Lynch syndrome cases are caused by PMS2. This disparity is primarily due to complications in the study of this gene caused by
Objective To determine if the prediction of the Malignancy of all adnexal mass using pattern recognition, i.e. subjective evaluation of gray-scale and Doppler ultrasound findings, is as accurate when based on static images as it is when based on a real-time ultrasound examination. Methods The static images of 166 non-consecutive patients with 'difficult' adnexal masses, who all underwent surgery a
Industry involvement in open source software development has become a popular practice among companies which, e.g., share software development costs with other community participants or implement an open source based business model. An increased understanding of the underlying development structure, especially in a case where the community participants are composed of competing industry members, c
We investigate electrical properties of self-assembled branched InAs nanowires. The branched nanowires are catalytically grown using chemical beam epitaxy, and three-terminal nanoelectronic devices are fabricated from the branched nanowires using electron-beam lithography. We demonstrate that, in difference from conventional macroscopic junctions, the fabricated self-assembled nanowire junction de
Abstract in UndeterminedJavaScript has gone from being a mechanism for providing dynamic web pages to an important component of many web applications. Currently one of the most popular type of web applications is so-called social networks, e.g., Facebook, Twitter, and MySpace. However, the workload and execution behavior of JavaScript in this context have not been fully explored or understood.In t
The aim of this paper is to integrate spatial cognition with lexical semantics. We develop cognitive models of actions and events based on conceptual spaces and vectors on them. The models are then used to present a semantic theory of verbs. We propose a two-vector model of events including a force vector and a result vector. We argue that our framework provides a unified account for a multiplicit
We report the measurement of cumulants (C-n,n = 1, ..., 4) of the net-charge distributions measured within pseudorapidity (vertical bar eta vertical bar < 0.35) in Au + Au collisions at root s(NN) = 7.7-200 GeV with the PHENIX experiment at the Relativistic Heavy Ion Collider. The ratios of cumulants (e.g., C-1/C-2, C-3/C-1) of the net-charge distributions, which can be related to volume independe
Background: In 2007, the World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) issued recommendations on diet, physical activity, and weight management for cancer prevention on the basis of the most comprehensive collection of available evidence. Objective: We investigated whether concordance with WCRF/AICR recommendations is related to risk of death. Design: The
An important regulatory suppressive function in autoimmune and other inflammatory processes has been ascribed to CD4(+) Foxp3(+) regulatory T cells (Tregs), which requires direct cell-cell communication between Tregs, effector T cells, and APCs. However, the molecular basis for these interactions has not yet been clarified. We show here that sialoadhesin (Sn), the prototype of the siglec family of
Den 6 december 2012 kom EU-domstolens dom i målet. Den omfattar 206 domsmotiv mot tribunalens 920 – således ett relativt sett lättillgängligt aktstycke, vilket också ligger i sakens natur med den begränsade talerätten vid överprövning. AZ yrkade att kommissionens beslut skulle ogiltigförklaras på grund av: (i) tribunalens felaktiga rättstillämpning vad gällde fastställandet av den relevanta markna
Preparation of a new type of cryostructured carbon particle macroporous gel with one-step sub-zero cross-linking was studied in this work. Aggregation of nano-and micro-particles of poly(N-isopropylacrylamide-co-allylamine) was used to form a polymeric network to integrate activated carbon particles. The cryostructured particle gel was compared with the conventional composite cryogel. The unique m
Lärosäten Syd är ett nära och formaliserat samarbete mellan de fem skånska och blekingska lärosätena, nämligen Blekinge Tekniska Högskola, Högskolan Kristianstad, Lunds universitet Malmö högskola och SLU/Alnarp, Figur 1. Universitet och högskolor har på ett nytt sätt blivit väsentliga regionala aktörer med ett stort ansvar inom ett antal viktiga områden som tillväxt, industri, kultur och arbetsmar
Sweden's connections to and relationships with the European and wider world is a field of study attracting considerable scholarly attention. The essays here, from archaeologists and historians, offer a new perspective on early modern Sweden as deeply affected by the increasing internationality of the 16th-18th centuries. Set in the socio-political context of an expanding and changing kingdom, they
Myoglobin has the ability to react with hydrogen peroxide, generating high-valent complexes similar to peroxidases (compounds I and II), and in the presence of excess hydrogen peroxide a third intermediate, compound III, with an oxymyoglobin-type structure is generated from compound II. The compound III is, however, easily one-electron reduced to peroxymyoglobin by synchrotron radiation during cry
Only a small fraction of the peptides generated inside the cell end up being presented by HLA-I on the cell surface. High stability of peptide-HLA-I complexes and a low HLA-I tapasin-facilitation have been proposed to predict immunogenicity. We here set out to investigate if these parameters correlated and defined immunogenic peptides. Both peptide-HLA-B*08:01 and peptide-HLA-A*02:01 complexes sho
BACKGROUND/OBJECTIVES: Cross-sectionally, educational attainment is strongly associated with the prevalence of obesity, but this association is less clear for weight change during adult life. The objective of this study is to examine the association between educational attainment and weight change during adult life in the European Prospective Investigation into Cancer and Nutrition (EPIC). SUBJECT
To facilitate reliable and accurate modeling of the late transition metal oxides from first principles, we present detailed and systematic calculations of the dynamical screened Coulomb interactions (Hubbard U) of MnO, FeO, CoO, and NiO within the constrained random-phase approximation. The matrix elements of the screened interactions are calculated in maximally localized Wannier functions. We con
I Jonstorps socken finns flera av de mest välkända stenåldersplatserna inom Skandinavien. De är uppmärksammade både nationellt och internationellt. Det är tack vare rektorn och arkeologen Oskar Lidén (1870–1957), som vi känner till dem. Han gjorde systematiska inventeringar och samlade in ett mycket stort stenåldersmaterial mellan åren 1910 och 1937. Han skrev många artiklar och böcker om fyndplat
