BACKGROUND: A new generation of positron emission tomography with computed tomography (PET-CT) was recently introduced using silicon (Si) photomultiplier (PM)-based technology. Our aim was to compare the image quality and diagnostic performance of a SiPM-based PET-CT (Discovery MI; GE Healthcare, Milwaukee, WI, USA) with a time-of-flight PET-CT scanner with a conventional PM detector (Gemini TF; P

Anaplastic thyroid cancer (ATC) is a rare and highly aggressive thyroid malignancy, usually resistant to conventional therapeutic strategies. The prognosis of ATC is extremely poor with a median survival rate of 6 months. Current treatment therapy includes surgical resection in combination with external radiotherapy and chemotherapy. The underlying mechanisms involved in ATC tumorigenesis is under

Beslutsfattare bör alltid vara skeptiska till universallösningar på sociala problem. Detta gäller inte minst BID-modellen, som har kritiserats bland annat för att skapa ett demokratiskt underskott i boendeområden, skriver forskare.

Changes in the immune system induced by tyrosine kinase inhibitors (TKI) have been shown to positively correlate with therapy responses in chronic myeloid leukemia (CML). However, only a few longitudinal studies exist and no randomized comparisons between two TKIs have been reported. Therefore, we prospectively analyzed the immune system of newly diagnosed CML patients treated with imatinib (n = 2

Rationale and Objectives: Emphysema is a hallmark of chronic obstructive pulmonary disease. The primary aim of this study was to investigate inter- and intraobserver agreement of visual assessment of mild emphysema in low-dose multidetector computed tomography of subjects in the pilot SCAPIS in order to certify consistent detection of mild emphysema. The secondary aim was to investigate the perfor

Large-scale land acquisitions are a critical driver of global socio-environmental change, in particular in the Global South. This study aims to investigate drivers, impacts and feedbacks of environmental change in Kilombero Valley, Tanzania, a region in rapid societal and environmental transformation. We use land cover classifications to map and quantify land cover changes from 1990 to 2016, and c

Purpose: After resuscitation from out-of-hospital cardiac arrest (OHCA), renal injury and hemodynamic instability are common. We aimed to assess the association between low cardiac output during targeted temperature management (TTM) and acute kidney injury (AKI) after OHCA. Materials and methods: Single-center substudy of 171 patients included in the prospective, randomized TTM-trial. Hemodynamic

Introduction: This study aimed to investigate the dose-response and pharmacology of a range of single doses of nebulised ensifentrine (RPL554), an inhaled dual phosphodiesterase (PDE) 3/4 inhibitor in patients with asthma. Methods: In this randomised, placebo-controlled, double-blind crossover study, patients received single nebulised doses of ensifentrine 0.4, 1.5, 6 and 24 mg, salbutamol 2.5 and

We consider the problem of grid-forming control of power converters in low-inertia power systems. Starting from an average-switch three-phase power converter model, we draw parallels to a synchronous machine (SM) model and propose a novel converter control strategy which dwells upon the main characteristic of a SM: the presence of an internal rotating magnetic field. In particular, we augment the

We detail here the convergence properties of a new model-independent imaging method, the Lévy expansion, that seems to play an important role in the analysis of the differential cross section of elastic hadron-hadron scattering. We demonstrate, how our earlier results concerning the Odderon effects in the differential cross-section of elastic proton-proton and proton-antiproton scattering as well

Review of Heimir Pálsson, Örlagasaga eyfirðings

This paper gives an overview of some feedback & control systems at Synchrotron SOLEIL that are in use or in development today. Beam stability is crucial and adressed in all SOLEIL aspects; Fast Orbit Feedback is a multi-input multi-output control system made to stabilize beam position perturbations in the low- & high frequency band. In addition, active RF cavities are used to maintain stab

Breast cancer is the major cause of deaths related to cancer for women worldwide. Although much is known about this malignancy, extensive research is still needed to gain complete understanding of the complexity of the disease. The inter and intra tumor heterogeneity is an important trait of breast cancer. The intratumor heterogeneity is reflected in sub-populations of cancer cells that appear to Breast cancer is the major cause of deaths related to cancer for women worldwide. Although much is known about this malignancy, extensive research is still needed to gain complete understanding of the complexity of the disease. The inter and intra tumor heterogeneity is an important trait of breast cancer. The intratumor heterogeneity is reflected in sub-populations of cancer cells that appear to

Objectives Global incidence and attention to childhood cancer is increasing and treatment abandonment is a major cause of treatment failure in low-and middle-income countries. The purpose of this study was to gain an understanding of factors contributing to non-adherence to treatment. Design A prospective cohort study with 2 year follow-up of incidence, family-reported motives and risk factors. Se

Follicular lymphoma (FL) is a heterogeneous disease with varying prognosis owing to differences in clinical, laboratory, and disease parameters. Although generally considered incurable, prognosis for early- and advanced-stage disease has improved because of therapeutic advances, several of which have resulted from elucidation of the biologic and molecular basis of the disease. The choice of treatm

Human breast cancer is believed to arise in luminal progenitors within the normal breast. A subset of these are double positive (DP) for basal and luminal keratins and localizes to a putative stem cell zone within ducts. We here present a new protocol based on a combination of CD146 with CD117 and CD326 which provides an up to thirty fold enrichment of the DP cells. We show by expression profiling

With growing tourism in natural areas, monitoring recreational impacts is becoming increasingly important. This paper aims to evaluate how di_erent trampling intensities a_ect some common Icelandic plant communities by using digital photographs to analyze and quantify vegetation in experimental plots and to monitor vegetation recovery rates over a consecutive three-year period. Additionally, it se