The temperature dependence of the conformational properties in simulations of the intrinsically disordered model protein histatin 5 has been investigated using different combinations of force fields, water models, and atomistic and coarse-grained methods. The results have been compared to experimental data obtained from NMR, SAXS, and CD experiments to assess the accuracy and validity of the simul

For many multivariable problems there are no efficient algorithms for finding solutions. To this day, conventional electronic computers mainly solve problems in a sequential manner. This sequential operation prevents problem-solving within a reasonable time-frame due to superpolynomial, and sometimes even exponential, time complexities. Developing powerful parallel computation techniques has there

What role does academic development have to play in responding to radical cultural shifts in the global landscape? Whose voices and identities are contributing to institutional change? This reflective essay encompasses the perspectives of the four international panellists in the opening plenary of the International Consortium for Educational Development (ICED) 2018 conference in Atlanta, Georgia,

Syftet med denna studie är att undersöka och jämföra hur undervisning i digitala miljöer konstrueras, dels i reflekterande texter skrivna av universitetslärare som deltog i en högskolepedagogisk kurs 2017–2018, dels i styrdokument om e-lärande från svenska lärosäten. Resultatet visar att lärarnas och styrdokumentens diskurser emellanåt står i kontrast till varandra. Medan de senare såväl explicit

The Homogeneous Charge Compression Ignition ({HCCI}) combustion principle lacks direct ignition timing control, instead the auto-ignition depends on the operating condition and fast combustion phasing control is necessary for reliable operation. A six-cylinder heavy-duty HCCI engine was controlled on a cycle-to-cycle basis in real time using a variety of sensors, actuators and control structures f

Multiplex separation of mixed cell samples is required in a variety of clinical and research applications. Herein, we present an acoustic microchip with multiple outlets and integrated pre-alignment channel to enable high performance and label-free separation of three different cell or particle fractions simultaneously at high sample throughput. By implementing a new cooling system for rigorous t

A measurement of the four-lepton invariant mass spectrum is made with the ATLAS detector, using an integrated luminosity of 36.1 fb −1 of proton-proton collisions at s = 13 TeV delivered by the Large Hadron Collider. The differential cross-section is measured for events containing two same-flavour opposite-sign lepton pairs. It exhibits a rich structure, with different mass regions dominated in th

WHAT WE ALREADY KNOW ABOUT THIS TOPIC: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Technology for cardiac output (CO) and blood volume measurements has been developed based on blood dilution with a small bolus of physiologic body temperature saline, which, after transcardiopulmonary mixing, is detected with ultrasound sensors attached to an extracorporeal arteriovenous loop using existing

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci assoc

We compared three different Graphical User Interfaces (GUI) that we have designed and implemented to enable human supervision of an unmanned ship. Our findings indicate that a 3D GUI presented either on a screen or in a Virtual Reality (VR) setting provides several objective and subjective benefits compared to a Baseline GUI representing traditional tools.

We discuss vector, axial-vector, scalar and pseudoscalar two-point functions at low and intermediate energies. We first review what is known from chiral perturbation theory, as well as from a heat kernel expansion within the context of an extended Nambu-Jona-Lasinio (ENJL) model. We derive then these two-point functions to all orders in the momenta and to leading order in 1/N c within the framewo