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Limited clinical efficacy of azacitidine in transfusion-dependent, growth factor-resistant, low- and Int-1-risk MDS : Results from the nordic NMDSG08A phase II trial

This prospective phase II study evaluated the efficacy of azacitidine (Aza) + erythropoietin (Epo) in transfusion-dependent patients with lower-risk myelodysplastic syndrome (MDS). Patients ineligible for or refractory to full-dose Epo + granulocyte colony stimulation factors for 48 weeks and a transfusion need of ≥ 4 units over 8 weeks were included. Aza 75mgm -2 d-1, 5/28 days, was given for six

p53 protein expression independently predicts outcome in patients with lower-risk myelodysplastic syndromes with del(5q)

Del(5q) myelodysplastic syndromes defined by the International Prognostic Scoring System as low- or intermediate- 1-risk (lower-risk) are considered to have an indolent course; however, recent data have identified a subgroup of these patients with more aggressive disease and poorer outcomes. Using deep sequencing technology, we previously demonstrated that 18% of patients with lower-risk del(5q) m

Allosteric and temperature effects on the plasma protein binding by streptococcal M protein family members

Most group A streptococcal strains bind immunoglobulins (Ig) and fibrinogen to their cell walls. It is shown in this paper that the Ig-binding of three different strains was much weaker at 37 degrees C than at room temperature (20 degrees C), whereas the fibrinogen binding was unaffected by temperature. The binding properties and molecular sizes of two purified group A streptococcal cell surface p

Formation of the alpha 1-microglobulin chromophore in mammalian and insect cells : a novel post-translational mechanism?

alpha 1-Microglobulin is an immunosuppressive plasma protein synthesized by the liver. The isolated protein is yellow-brown, but the hypothetical chromophore has not yet been identified. In this work, it is shown that a human liver cell line, HepG2, grown in a completely synthetic and serum-free medium, secretes alpha 1-microglobulin which is also yellow-brown, suggesting a de novo synthesis of th

PAC dosing to an MBBR – Effects on adsorption of micropollutants, nitrification and microbial community

Two nitrifying MBBR reactors were operated in parallel, one with PAC dosing and one without, to determine the effects of PAC dosing on nitrification and micropollutant adsorption in municipal wastewater. The removal of micropollutants was evaluated for several doses of PAC and batch experiments were performed to measure adsorption kinetics and nitrification rates. The influence of PAC on the nitri

Pattern recognition in high energy physics with artificial neural networks - JETNET 2.0

A F77 package of adaptive artificial neural network algorithms, JETNET 2.0, is presented. Its primary target is the high energy physics community, but it is general enough to be used in any pattern-recognition application area. The basic ingredients are the multilayer perceptron back-propagation algorithm and the topological self-organizing map. The package consists of a set of subroutines, which

Neutral-current supernova-neutrino cross sections for Pb 204,206,208 calculated by Skyrme quasiparticle random-phase approximation

The present work constitutes a detailed study of neutral-current (NC) supernova-neutrino scattering off the stable even-even lead isotopes Pb204,206,208. This is a continuation of our previous work [Almosly et al., Phys. Rev. C. 94, 044614 (2016)10.1103/PhysRevC.94.044614] where we investigated charged-current processes on the same nuclei. As in the previous work, we have adopted the quasiparticle

Ligament lengthening compared with simple division of the transverse carpal ligament in the open treatment of carpal tunnel syndrome

It has been suggested that the new (and controversial) endoscopic techniques are more successful than standard operation for the preservation of the ligamentous pulley function across the carpal tunnel and for the separation of the gliding structures from the subcutaneous tissues after release of the carpal ligament in carpal tunnel syndrome. We therefore decided to study the possible importance o

Prediction of recidivism in a long-term follow-up of forensic psychiatric patients : Incremental effects of neuroimaging data

One of the primary objectives in forensic psychiatry, distinguishing it from other psychiatric disciplines, is risk management. Assessments of the risk of criminal recidivism are performed on a routine basis, as a baseline for risk management for populations involved in the criminal justice system. However, the risk assessment tools available to clinical practice are limited in their ability to pr

Gambling Disorder in Male Violent Offenders in the Prison System : Psychiatric and Substance-Related Comorbidity

Gambling disorder is an addiction that can cause major suffering, and some populations seem to be more vulnerable than others. Offender populations have a remarkably high prevalence of gambling problems and they are also over-represented in a number of diagnoses related to gambling disorder, like substance use disorders and antisocial personality disorder. Yet, there are few studies investigating

Facing metaphors as the most complex iconic signs: Toward a synthetic analysis of figuration in Greek street art

Cognitive linguistic and semiotic accounts of metaphors have often discussed the complex phenomenon of metaphor in various ways, often addressing factors such as universality and conventionality, context-sensitivity, cross-cultural variation and creativity, deliberateness and “multimodality”. However, in most cases, such factors are investigated in isolation (cf. Gibbs 2017). Therefore, we propose

The significance of bicuspid aortic valve after surgery for acute type A aortic dissection

OBJECTIVE: Decision-making concerning the extent of the repair of acute type A aortic dissection (ATAAD) includes functional and anatomical assessment of the aortic valve. We hypothesized that bicuspid aortic valve (BAV) does not impact outcome after surgery for ATAAD. We therefore evaluated the outcome after ATAAD surgery in relation to the presence of BAV, acute aortic regurgitation (AR), and su

Prothrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma

Molecules containing the 33-kDa plasma protein alpha1-microglobulin were isolated from human plasma by anti-(alpha1-microglobulin) affinity chromatography. Five major bands could be seen after electrophoretic separation of the alpha1-microglobulin-containing proteins under native conditions. Immunoblotting demonstrated alpha1-microglobulin in all five bands. Two of these have been described previo

Low plasma concentrations of apolipoprotein M are associated with disease activity and endothelial dysfunction in systemic lupus erythematosus

Background: Apolipoprotein M (apoM) is a 25-kDa apolipoprotein present in 5% of high-density lipoprotein (HDL) particles. It is suggested to be anti-atherogenic and to play a key role in sustaining endothelial barrier integrity. SLE patients have increased cardiovascular disease risk, and we aimed to investigate if apoM levels reflect endothelial function in SLE. Since apoM plasma levels decrease

Plasma Heme Scavengers Alpha-1-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies

Women with established preeclampsia (PE) have increased plasma concentration of free fetal hemoglobin. We measured two hemoglobin scavenger system proteins, hemopexin (Hpx) and alpha-1-microglobulin (A1M) in maternal plasma using enzyme-linked immunosorbent assay during the late second trimester of pregnancy in women with high and low risk of developing PE. In total 142 women were included in nest