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Colour vision: parallel pathways intersect in Drosophila.

In the last one hundred years, colour vision has been demonstrated in bees and many other insects. But the underlying neural wiring remained elusive. A new study on Drosophila melanogaster combining behavioural and genetic tools yields surprising insights.

The genetics of migration on the move.

Across a range of organisms, related species or even populations of the same species exhibit strikingly different scales and patterns of movement. A significant proportion of the phenotypic variance in migratory traits is genetic, but the genes involved in shaping these phenotypes are still unknown. Although recent achievements in genomics will evolve migratory genetics research from a phenotypic

The Combined Role of Galactose-Deficient IgA1 and Streptococcal IgA-Binding M Protein in Inducing IL-6 and C3 Secretion from Human Mesangial Cells: Implications for IgA Nephropathy.

IgA nephropathy (IgAN) is characterized by mesangial cell proliferation and extracellular matrix expansion associated with immune deposits consisting of galactose-deficient polymeric IgA1 and C3. We have previously shown that IgA-binding regions of streptococcal M proteins colocalize with IgA in mesangial immune deposits in patients with IgAN. In the present study, the IgA-binding M4 protein from

Semileptonic kaon decay in staggered chiral perturbation theory

The determination of vertical bar V-us vertical bar from kaon semileptonic decays requires the value of the form factor f(+)(q(2) = 0), which can be calculated precisely on the lattice. We provide the one-loop partially quenched staggered chiral perturbation theory expressions that may be employed to analyze staggered simulations of f(+)(q(2)) with three light flavors. We consider both the case of

Superior compliance with a neuromuscular training programme is associated with fewer ACL injuries and fewer acute knee injuries in female adolescent football players: secondary analysis of an RCT

Background Little is known about the influence of compliance with neuromuscular training (NMT) on the knee injury rate in football. Aim To evaluate team and player compliance with an NMT programme in adolescent female football and to study the association between compliance and acute knee injury rates. Methods Prospective cohort study based on a cluster randomised controlled trial on players aged

Growth-limiting role of endothelial cells in endoderm development.

Endoderm development is dependent on inductive signals from different structures in close vicinity, including the notochord, lateral plate mesoderm and endothelial cells. Recently, we demonstrated that a functional vascular system is necessary for proper pancreas development, and that sphingosine-1-phosphate (S1P) exhibits the traits of a blood vessel-derived molecule involved in early pancreas mo

Explaining biological depression theories

I AM GRATEFUL TO Dien Ho and James Phillips for their comments on my article (Mulinari, 2018). Although they approach the topic from different perspectives, they both seem to find my account of the evolution of monoamine theories into neuroplasticity theories to be compelling. They especially seem to find my principal argument to be persuasive: Until quite recently, the use of drugs to generate an

Investigation of Dietary Factors and Endometrial Cancer Risk Using a Nutrient-wide Association Study Approach in the EPIC and Nurses' Health Study (NHS) and NHSII.

Data on the role of dietary factors in endometrial cancer development are limited and inconsistent. We applied a "nutrient-wide association study" approach to systematically evaluate dietary risk associations for endometrial cancer while controlling for multiple hypothesis tests using the false discovery rate (FDR) and validating the results in an independent cohort. We evaluated endometrial cance

Barriers to senior citizens' outdoor mobility in Europe

The aim of this study was to picture perceived problems amongst older citizens in the traffic environment. Moreover, answers to the question why measures that are known to be efficient concerning the mobility of senior citizens are often not implemented. Eight EU countries participated in the study, involving both senior citizens and experts (researchers, decision makers and practitioners who deal

Measuring disease activity in adults with systemic lupus erythematosus: the challenges of administrative burden and responsiveness to patient concerns in clinical research.

Measuring lupus disease activity accurately remains a challenging and demanding task given the complex multi-system nature of lupus, an illness known for its variability between patients and within the same patient over time. Many have attempted to define what disease activity means and how it should be measured, and several instruments were devised for a standardized assessment of disease activit

Defending the organisation, not the members: Unions and the reform of job security legislation in Western Europe

European labour markets are often described as rigid with comparatively high levels of job protection that do not allow for the flexible adjustment of employment to economic fluctuations. This interpretation overlooks important sources of flexibility, however. Research has shown that recent labour market policy reforms have allowed for the creation of two-tier labour markets consisting of insiders

A DNA Methylation Map of Human Atherosclerosis.

-Epigenetic alterations may contribute to the development of atherosclerosis. In particular, DNA methylation, a reversible and highly regulated DNA modification, could influence disease onset and progression since it functions as an effector for environmental influences, including diet and lifestyle, both of which are risk factors for cardiovascular diseases.

Density functional theory for Yukawa fluids

We develop an approximate field theory for particles interacting with a generalized Yukawa potential. This theory improves and extends a previous splitting field theory, originally developed for counterions around a fixed charge distribution. The resulting theory bridges between the second virial approximation, which is accurate at low particle densities, and the mean-field approximation, accurate

Works of art: Aesthetic Ambitions in Design Hotels

This paper analyzes a genre of hotels that has grown substantially the latest decades: namely one that includes hotels that go under names such as design hotels, boutique hotels, or "contemporary" hotels. It presents elements of the transnational discourse of this genre and shows how these are translated, materialized and localized. Individual hotels are used as illustrative examples of how discur

Risk of breast cancer among patients with bioprosthetic or mechanical valve replacement: a population-based study in Sweden.

The association between breast cancer and warfarin is inconclusive as most previous studies examined their association using patients with thromboembolism, whereas thromboembolism itself is a risk factor for cancer. We explored this issue using patients received mechanical heart valves replacement as a proxy for warfarin exposure as these patients need a lifelong warfarin treatment, and compared t

Allelic variation in a fatty-acyl reductase gene causes divergence in moth sex pheromones

Pheromone-based behaviours are crucial in animals from insects to mammals, and reproductive isolation is often based on pheromone differences. However, the genetic mechanisms by which pheromone signals change during the evolution of new species are largely unknown. In the sexual communication system of moths (Insecta: Lepidoptera), females emit a species-specific pheromone blend that attracts male

Seasonal migration to high latitudes results in major reproductive benefits in an insect

Little is known of the population dynamics of long-range insect migrants, and it has been suggested that the annual journeys of billions of nonhardy insects to exploit temperate zones during summer represent a sink from which future generations seldom return (the “Pied Piper” effect). We combine data from entomological radars and ground-based light traps to show that annual migrations are highly a