Driving automation systems, including autonomous driving and advanced driver assistance, are an important safety-critical domain. Such systems often incorporate perception systems that use machine learning to analyze the vehicle environment. We explore new or differing topics and challenges experienced by practitioners in this domain, which relate to requirements engineering (RE), quality, and sys

This book explores the relationship between tourism and high-magnitude storm events, including cyclones, hurricanes and typhoons and flooding, across all stages of a disaster. It considers the measures available to manage tourism after major storms and floods, examines the means to mitigate the potential impacts of these disasters on tourism, and provides insights into the ethical and socioeconomi

Phenotypic plasticity is produced and maintained by processes regulating the transcriptome. While differential gene expression is among the most important of these processes, relatively little is known about other sources of transcriptional variation. Previous work suggests that alternative splicing plays an extensive and functionally unique role in transcriptional plasticity, though plastically s

One of the hallmarks of type 1 but also type 2 diabetes is pancreatic islet inflammation, associated with altered pancreatic islet function and structure, if unresolved. IL-1β is a proinflammatory cytokine which detrimentally affects β-cell function. In the course of diabetes, complement components, including the central complement protein C3, are deregulated. Previously, we reported high C3 expre

Purpose: To monitor cardiovascular health, in 2022, the American Heart Association (AHA) updated the construct “Life’s Simple 7” (LS7) to “Life’s Essential 8” (LE8). This study aims to analyze the associations and capacity of discrimination of LE8 and LS7 in relation to self-rated health (SRH) and health-related quality of life (HRQoL). Methods: This study from the Swedish CArdioPulmonary bioImage

The most effective way to avoid intense inter- and intra-specific competition at the dung source, and to increase the distance to the other competitors, is to follow a single straight bearing. While ball-rolling dung beetles manage to roll their dung balls along nearly perfect straight paths when traversing flat terrain, the paths that they take when traversing more complex (natural) terrain are n

Objective In numerous studies aspiring to clarify when to discontinue direct oral anticoagulants (DOAC) before central nerve blocks (CNB), information about the technique: spinal, epidural, indwelling catheter, multiple attempts, ‘bloody tap’: is incomplete. This creates difficulty making evidence-based recommendations regarding the safest time frame between the last dose of DOAC and CNB to avoid

Leadership is complex, and leadership in a global business is no less complex. To a great extent, the challenge in leadership is to look at what requirements the specific management task poses, and what opportunities it creates, and to be aware of what expectations and ideas are present, for example in the form of cultural values within a given organization. Greater complexity and variation in app

Context: The capacity of a landscape to maintain multifunctionality through ongoing pressures relates to its sustainability and is affected by land use policy and environmental changes. In coastal zones, limited empirical evidence exists regarding the impact of macro-level policy changes on local landscapes and their resulting temporal and spatial responses. Objectives: This paper investigates the

Mathematical models of cancer and bacterial evolution have generally stemmed from a gene-centric framework, assuming clonal evolution via acquisition of resistance-conferring mutations and selection of their corresponding subpopulations. More recently, the role of phenotypic plasticity has been recognized and models accounting for phenotypic switching between discrete cell states (e.g., epithelial

Context. The star cluster initial mass function is observed to have an inverse power law exponent around 2, yet there is no consensus on what determines this distribution, and why some variation is observed in different galaxies. Furthermore, the cluster formation efficiency (CFE) covers a range of values, particularly when considering different environments. These clusters are often used to empir

Syftet med denna studie är att ge klarhet i hur musiklärare kan arbeta med undervisning för hållbar utveckling utifrån frågorna; Hur arbetar musiklärare med undervisning för hållbar miljö och Hur arbetar musiklärare med undervisning för hållbar demokrati? Studien presenterar tidigare forskning om undervisning för hållbar utveckling för att få ett historiskt perspektiv på frågan. Studien tar också

I dagens teknologiskt avancerade samhälle har föräldrar börjat integrera digitala övervakningsverktyg som en del av föräldraskapet. Teknologins framsteg har gett möjlighet till nya typer av föräldrakontroller, där digital övervakning kan användas som verktyg för insamling av detaljerad information om barns digitala och fysiska fotspår. De nya möjligheterna att övervaka väcker en rad komplexa frågo

I denna analys studeras hur Disneys nyinspelning av Den Lilla Sjöjungfrun (2023) skiljer sig från originalet Den Lilla Sjöjungfrun (1989) i sin framställning av genus. Remaken är anpassad för ett modernt samhälle och har därför lagt fokus på att uppdatera de delar av filmen som kan anses som problematiska eller utdaterade. För att analysera materialet används en kvalitativ text- och bildanalys där

Syftet med denna uppsats är att utforska hur de som tillskriver sig till MGTOW:s filosofi på Flashback Forum formar de narrativ som motiverar dem att åtminstone i sinnet överge kvinnor. Det är ett försök att förstå de psykologiska aspekterna samt filosofins natur som sprungen ur internet ligger i centrum. I kort ämnar denna uppsats att undersöka de extremistiska narrativ som uppstår i separatistis

Sedan urminnes tider har frågor om etik och moral haft stor inverkan på människors liv. I den globaliserade och digitala värld vi idag lever i är dessa fortfarande aktuella, men har kommit att förändras. Då vi har gått från att befinna oss i en kollektiv till en konnektiv kontext, och vår kommunikation inte längre enbart sker ansikte mot ansikte, har nya etiska och moraliska frågor uppkommit. Den

Size Exclusion Chromatography (SEC) is a crucial analytical tool employed by Novo Nordisk for the assessment of potential aggregation in active pharmaceutical ingredients (API) derived from peptides and protein biopharmaceuticals. This investigation focuses on SEC analyses conducted under denaturing conditions, utilizing Ultra High-Performance Liquid Chromatography (HULK) adapted columns. Intrigui

Despite improvements in treatment of mantle cell lymphoma (MCL), most patients eventually relapse. In this multicenter phase 1b/2 trial, we evaluated safety and efficacy of minimal residual disease (MRD)-driven venetoclax, lenalidomide, and rituximab (venetoclax-R2) in relapsed/refractory (R/R) MCL and explored the feasibility of stopping treatment in molecular remission. The primary end point was

Type Ia Supernovae (SNe Ia) are considered the most reliable standard candles and they have played an invaluable role in cosmology since the discovery of the Universe's accelerated expansion. During the last decades, the SNe Ia samples have been improved in number, redshift coverage, calibration methodology, and systematics treatment. These efforts led to the most recent “Pantheon” (2018) and “Pan

The delta deposits in Jezero crater contain sedimentary records of potentially habitable conditions on Mars. NASA's Perseverance rover is exploring the Jezero western delta with a suite of instruments that include the RIMFAX ground penetrating radar, which provides continuous subsurface images that probe up to 20 meters below the rover. As Perseverance traversed across the contact between the Jeze