Background--Long-term disease progression after myocardial infarction (MI) is inadequately understood. We evaluated the pattern and angiographic properties (culprit lesion [CL]/non-CL [NCL]) of recurrent MI (re-MI) in a large real-world patient population. Methods and Results--Our observational study used prospectively collected data in 108 615 patients with first-occurrence MI enrolled in the SWE

Relationships between health professionals and pharmaceutical manufacturers can unduly influence clinical practice. These relationships are the focus of global transparency efforts, including in Europe. We conducted a descriptive content analysis of the transparency provisions implemented by February 2017 in nine European Union countries concerning payments to health professionals, with duplicate Relationships between health professionals and pharmaceutical manufacturers can unduly influence clinical practice. These relationships are the focus of global transparency efforts, including in Europe. We conducted a descriptive content analysis of the transparency provisions implemented by February 2017 in nine European Union (EU) countries concerning payments to health professionals, with dupli

This text sheds light on the delicate practice of including different religious as well as nonreligious expressions in a shared room. The effects of design decisions in a “room of silence” at a Swedish hospital are studied over a transitional period of renovation of the space. We observe the impact of materiality in the room’s establishment, renovation, and usage, and show how the room’s interior

The primary objective of this study is to compare the accuracy of two risk models, International Heart Transplantation Survival Algorithm (IHTSA), developed using deep learning technique, and Index for Mortality Prediction After Cardiac Transplantation (IMPACT), to predict survival after heart transplantation. Data from adult heart transplanted patients between January 1997 to December 2011 were c

Proteiner är en av människokroppens byggstenar och har en mängd viktiga ochnödvändiga biologiska funktioner genom att delta i kemiska reaktioner och processer.De flesta proteiner har en bindningsficka som styr proteinets biologiska funktiongenom bindning av andra molekyler. Denna biologiska funktion kan i vissa fallkopplas till ett sjukdomstillstånd. Organiska molekyler som binder starkt tillbindnExperimental drug discovery is very time-consuming, risky and comes at a huge cost, typically several billion USD per drug. Even though decades of experimental drug discovery have provided cures of many diseases, there are still diseases for which there is no effective drug available. If drug development could be performedby theoretical and computational methods it would be of great advantage to h

The study of metaphor currently being made in the wake of Lakoff may contribute important knowledge of the traits most relevant to iconicity, but it fails to account for the nature of metaphors, which suppose a wilful misclassification of phenomena, which leads to a state of semantic tension. Taking our point of departure in an interpretation of the Peircean categories that we have proposed in a r

Introduction: Trachoma is the leading infectious cause of blindness worldwide. It is more common in areas where people are socio-economically deprived. Although trachoma is endemic in 571 districts in Ethiopia, its prevalence has not been studied among school children in Harari Region. Objective: To assess the prevalence of trachoma eye infection and factors associated with it among Grades 1-8 sch

Risk for criminal behavior (CB), alcohol use disorder (AUD), and drug abuse (DA) are known to be familial. We know less about their transmission across three generations. We examined 844,109 probands born in Sweden 1980–1990, their parents, aunts/uncles, and grandparents for registration in population-based registers for CB, AUD, and DA. Mean tetrachoric relative-proband correlations (95% CIs) wer

Hard X-ray photoelectron spectroscopy (HAXPES) has been used to study the bulk electronic structure of thin molecular films of the organic compounds 2,2′,7,7′-tetrakis (N,N’-di-p-methoxyphenyl-amine)-9,9’-spiro-bifluorene (spiro-OMeTAD), 4-(diethylamino)-benzaldehyde-1,1)-diphenyl-hydrazone (DEH) and poly(3-hexylthiophene) (P3HT). Molecular layers of these compounds are hole conducting, a property

The phase behavior in the oleic acid/sodium oleate/normal saline (0.15 M NaCl aqueous solution) system has been determined. For this purpose visual inspection of samples between crossed polarizers, and Small Angle X-ray diffraction was used to identify the various phases and their unit cell dimensions. A rich phase behavior was observed for the ternary system, featuring reverse micellar, micellar

We describe a class of three Higgs doublet models (3HDMs) with a softly broken U(1) × U(1) family symmetry that enforces a Cabibbo-like quark mixing while forbidding tree-level flavour changing neutral currents. The hierarchy in the observed quark masses is partly explained by a softer hierarchy in the vacuum expectation values of the three Higgs doublets. As a consequence, the physical scalar spe

Innovations in urban governance such as Urban Living Labs (ULL) are expected to accelerate the transition towards more sustainable and climate-resilient cities. This article reviews different ULL across Europe and explores the role and potential capacity of municipalities in the development of and/or facilitation of ULL as a form of experimental governance. It focuses on the role of the public sec

When using fluorescence microscope techniques to study cells, it is essential that the cell structure and contents are preserved after preparation of the samples, and that the preparation method employed does not create artefacts that can be perceived as cellular structure/components. γ-Tubulin forms filaments that in some cases are immunostained with an anti-γ-tubulin antibody, but this immunosta

This paper studies the role of imported inputs in explaining firms’ export behaviour. Unlike most of the existing literature we are also able to control for the participation of domestic firms to multinational networks. This allows us to test to what extent the recurrent evidence that importing foster exporting activity is instead a figment of the fact that importers are also part of multinational