Objective To describe the frequency of myocardial infarction (MI) prior to the diagnosis of systemic lupus erythematosus (SLE) and within the first 2 years of follow-up. Methods The systemic lupus international collaborating clinics (SLICC) atherosclerosis inception cohort enters patients within 15 months of SLE diagnosis. MIs were reported and attributed on a specialised vascular event form. MIs

Context. The Gaia-ESO Public Spectroscopic Survey using FLAMES at the VLT has obtained high-resolution UVES spectra for a large number of giant stars, allowing a determination of the abundances of the key chemical elements carbon and nitrogen at their surface. The surface abundances of these chemical species are known to change in stars during their evolution on the red giant branch (RGB) after th

A feasibility study of a Bayesian based algorithm for orphan source localization by means of mobile gamma spectrometry is presented. The method was tested on three types of gamma sources (137Cs, 133Ba and 131I) using a HPGe detector mounted on a vehicle. Estimates on source activity and source locations were within 51% and 29% of actual values, respectively. Further studies are required to validat

Background: Numerous different types of variations can occur in DNA and have diverse effects and consequences. The Variation Ontology (VariO) was developed for systematic descriptions of variations and their effects at DNA, RNA and protein levels. Results: VariO use and terms for DNA variations are described in depth. VariO provides systematic names for variation types and detailed descriptions fo

Molecular-level computer simulations of peptide aggregation, translocation, and protonation at and in biomembranes are impeded by the large time and length scales involved. We present a computationally efficient, coarse-grained, and solvent-free model for the interaction between lipid bilayers and peptides. The model combines an accurate description of mechanical membrane properties with a new gra

Background: Many studies have investigated the prognostic role of biomarkers in colorectal liver metastases (CRLM). However, no biomarker has been established in routine clinical practice. The aim of this study was to scrutinize the current literature for biomarkers evaluated by immunohistochemistry as prognostic markers in patients with resected CRLM. Methods: A systematic review was performed ac

We present measurements of one-dimensional superconductor-semiconductor Coulomb islands, fabricated by gate confinement of a two-dimensional InAs heterostructure with an epitaxial Al layer. When tuned via electrostatic side gates to regimes without subgap states, Coulomb blockade reveals Cooper-pair mediated transport. When subgap states are present, Coulomb peak positions and heights oscillate in

Bidraget analyserar Kinas folkrättsliga strategi med avseende på att använda militärt våld i cyberrymden. Kinas statspraxis och opinio juris (d v s dess folkrättsliga övertygelse) undersöks och kinesiska folkrättsvetenskapliga yttranden oc ståndpunkter granskas.

Recension av Tim Marshall, Geografins makt: Tio kartor som förklarar världen, övers. Pär Svensson, Volante, Stockholm 2018 (343 s.) och Thomas Reinertsen Berg, Kartornas historia, övers. Jan Wibom, Lind & Co, Stockholm 2018 (351 s.).

I forskningsmiljön Children’s and Young People’s Health in Social Context,CYPHiSCO, förenar forskare vid Högskolan Kristianstad sitt intresse för barns, tonåringars och unga vuxnas psykiska och fysiska hälsa, välbefinnande och delaktighet. I CYPHiSCO bedrivs både grundforskning om faktorer som står i samband med hälsa och tillämpad forskning såsom aktionsforskning eller utvärderingar av prevention

Det estetiska området har visat sig viktigt för människors möjlighet att uttrycka sig och kommunicera med andra. Förmåga till socialt och kulturellt deltagande har stor betydelse för individens hälsa och välbefinnande. Intresset för att undersöka och utveckla estetiska aktiviteter för barn och unga med olika slag av funktionsnedsättning måste dock anses vara ganska begränsat, något som står i kont

Computers and digital instruments change the way we think about ourselves and other people, demonstrated by an example with a girl who imagined that she had a computer in her brain where she could click on “Music” in the menu to hear music. This chapter argues that good music technology should allow play and unpredictable events and support a balance between challenge and ability. Digital instrume

Some 4 billion years ago, nature began the experiment that led to you, that bird on the branch, that branch, and everything else which is alive that you see around you. The generating process of all this splendid life is, of course, evolution. Evolution works not only on the macroscopic scale (think eyes, muscles, wings) but also on the molecular scale (think molecular antennas, nanoscale muscles,The sequence diversity of protein families is a result of the biophysical selection pressures that shaped their evolutionary history. Among the dominant pressures is selection for protein thermostability, which in itself is an attractive target in protein engineering because of its importance for various biopharmaceutical properties, the performance of industrial enzymes, and the ability to design

A search for dark matter produced in association with a Higgs boson decaying to b-quarks is performed using pp collisions at a centre-of-mass energy of √s=13 TeV. The dataset has an integrated luminosity of 79.8 fb−1 and was recorded with the ATLAS detector at the Large Hadron Collider. Selected collision events comprise large missing transverse momentum and either two b-tagged small radius jets o