AIM: Epidural analgesia reduces the surgical stress response. However, its effect on pro- and anti-inflammatory cytokines in the genesis of inflammation following major abdominal surgery remains unclear. Our main objective was to elucidate whether perioperative epidural analgesia prevents the inflammatory response following colorectal cancer surgery.METHODS: Ninety-six patients scheduled for open

Rekommendationerna för hur träning bör formas för att ge största möjliga hälsovinster har ändrats genom tiderna. Under 90-talet sökte man en nedre gräns gällande intensitet på träningen för att få en träningseffekt. Under 2000-talet växte sedan tankar kring träning på recept fram och koncepten FaR och FYSS myntades. Syftet med träning på recept är dubbelt, både primär- och sekundärprevention. Vid

Seagrass meadows are able to store significant amounts of organic carbon in their underlying sediment, but global estimates are uncertain partly owing to spatio-temporal heterogeneity between and within areas and species. In order to provide robust estimates, there is a need to better understand the fate of, and mechanisms behind, organic carbon storage. In this observational study, we analyse a s

In species with chromosomal sex determination, X chromosomes are predicted to evolve faster than autosomes becauseof positive selection on recessive alleles or weak purifying selection. We investigated X chromosome evolution inStegodyphus spiders that differ in mating system, sex ratio, and population dynamics. We assigned scaffolds to Xchromosomes and autosomes using a novel method based on flow In species with chromosomal sex determination, X chromosomes are predicted to evolve faster than autosomes because of positive selection on recessive alleles or weak purifying selection. We investigated X chromosome evolution in Stegodyphus spiders that differ in mating system, sex ratio, and population dynamics. We assigned scaffolds to X chromosomes and autosomes using a novel method based on fl

Giant cell arteritis (GCA), affects an age group where osteoporosis is common. A well-established treatment for osteoporosis is medication with bisphosphonates. Bisphosphonates are overall well-tolerated but can trigger several different acute inflammatory reactions with systemic features and symptoms and signs from the ocular and musculoskeletal system, all of which resemble those of GCA. Here is

In this paper we study ensembles of Abelian group codes on symmetric channels. Our main example is the AWGN channel where the inputs are restricted to a GU constellation admitting ℤm as a generating group. For codes which are ℤm-free modules, we prove a sort of Shannon theorem which exactly characterizes which are the rates for which reliable transmission is possible. In particular we prove that f

Is product-specific linkage of extraction and precipitation in your downstream processing future?

A new aid to perimetric analysis, the Glaucoma Hemifield Test, primarily evaluates up-down differences in automated static visual field tests. We analyzed the visual fields of 163 eyes of 163 normal subjects and 77 eyes of 77 patients with glaucoma diagnosed on bases other than perimetry using the Glaucoma Hemifield Test and a similar, previously developed, hemifield analysis method. The performan

Eucalyptus plantations have been established in many areas of the world due to their fast growth and profitability. In NW Spain, Eucalyptus plantations now cover a larger area than native forests. Although Eucalyptus plantations have been shown to affect biodiversity, relatively few studies have compared their effect on multiple taxonomic groups and different aspects of biodiversity. We compared h

To meet future challenges in urban development with denser housing and sustainable water resources, society needs to take actions. Densification of housing is met by expanding housing into old industrial areas often contaminated and water resources are already affected in some areas by over exploiting, pollutants spreading and a changing climate leading to changes in recharge.Growing concerns are

BACKGROUND: Abiraterone acetate plus prednisone significantly improved radiographic progression-free survival compared with placebo plus prednisone in men with chemotherapy-naive castration-resistant prostate cancer at the interim analyses of the COU-AA-302 trial. Here, we present the prespecified final analysis of the trial, assessing the effect of abiraterone acetate plus prednisone on overall s

BACKGROUND: Enzalutamide is an oral androgen-receptor inhibitor that prolongs survival in men with metastatic castration-resistant prostate cancer in whom the disease has progressed after chemotherapy. New treatment options are needed for patients with metastatic prostate cancer who have not received chemotherapy, in whom the disease has progressed despite androgen-deprivation therapy.METHODS: In

Objective: In March 2018, the Explorer study, an international, double-blind, randomised controlled trial (RCT), established that adding a TLC-NOSF (UrgoStart Contact, Laboratoires Urgo, France) dressing to good local standard of care (SoC) significantly and substantially increases wound closure and reduces the healing time of neuroischaemic diabetic foot ulcers (DFU). Besides the TLCNOSF treatmen