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Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified 66 loci at 'genome-wide significance' (P < 5 × 10 '8) at the time of this analysis, but a much larger number of putative loci at a false discovery rate (FDR) of 5% (refs. 1,2,3,4). Here we leverage an interim release of UK Biobank (UKBB) data to evaluate the validity of the FDR approach. We tested a CAD phenotyp
The rejection of forward jets originating from additional proton–proton interactions (pile-up) is crucial for a variety of physics analyses at the LHC, including Standard Model measurements and searches for physics beyond the Standard Model. The identification of such jets is challenging due to the lack of track and vertex information in the pseudorapidity range | η| > 2.5. This paper presents a n
In aqueous systems with immobilized macromolecules, including biological tissues, the longitudinal spin relaxation of water protons is primarily induced by exchange-mediated orientational randomization (EMOR) of intra- and intermolecular magnetic dipole-dipole couplings. Starting from the stochastic Liouville equation, we have previously developed a rigorous EMOR relaxation theory for dipole-coupl
The Late Neolithic flint daggers of Scandinavia have long fascinated contemporary flintknappers, due to the beauty of some specimens and the presumed skill required to make them. Examination of populations of daggers in museum collections reveals differences in knapping quality. Such differences are commonly ascribed to variations in skill levels on the part of their makers, and high skill is ofte
ATLAS measurements of two-particle correlations are presented for s=5.02 and 13 TeV pp collisions and for sNN=5.02 TeV p+Pb collisions at the LHC. The correlation functions are measured as a function of relative azimuthal angle Δφ, and pseudorapidity separation Δη, using charged particles detected within the pseudorapidity interval |η|2, is studied using a template fitting procedure to remove a "b
The effect of a user’s body on channel characteristics for single user downlink transmission in an urban scenario for the 5th generation (5G) systems is investigated with ray-tracing at 15 GHz and 28 GHz. Three different designs of user equipment (UE) antennas are fabricated and integrated into a mobile phone prototype, and their 3D radiation patterns are measured both with and without
We report on the growth of single crystal InAs NWs on Si/SiOx substrates by chemical vapor deposition (CVD). By adjusting growth parameters, the diameters, morphology, length and the proportion of superlattice ZB InAs NWs (NWs) can be controlled on a Si/SiOx substrate. Our work provides a low-cost route to grow and phase-engineer single crystal InAs NWs for a wide range of potential applications.
Fluorinated spheres with grafted poly(ethylene glycol) (PEG) have been synthesized using a semi-batch emulsion polymerization in which the initiator is fed slowly to the reaction. In this way, PEG-grafted colloidal spheres can be fabricated with varying PEG chain length, different cores and varying degrees of crosslinking. The resulting batches have been characterized using disc centrifuge photose
The present study investigated the relative importance of two explanations behind perceptions of gender discrimination in hiring: prototypes and same-gender bias. According to the prototype explanation, people perceive an event as discrimination to the extent that it fits their preconceptions of typical discrimination. In contrast, the same-gender bias explanation asserts that people more readily
The G-protein-coupled receptors LGR4, LGR5 and LGR6 are Wnt signaling mediators, but their functions in squamous cell carcinoma (SCC) are unclear. Using lineage tracing in Lgr5-EGFP-CreERT2/Rosa26-Tomato and Lgr6-EGFP-CreERT2/Rosa26-Tomato reporter mice, we demonstrate that Lgr6, but not Lgr5, acts as an epithelial stem cell marker in SCCs in vivo. We identify, by single-molecule in situ hybridiza
We demonstrate one-dimensional (1D) electrical modeling of InP nanowire array solar cells. This 1D modeling gives accurate description of the current voltage response even at high surface recombination velocity. The 1D electrical model decreases the simulation time by 3 orders of magnitude compared to a full three-dimensional (3D) model.
Nanowires (NWs) have potential to enable new types of light-emitting diodes (LEDs), which also entail challenges for the development of improved full device simulation models. In this work we calculate the extraction efficiency and emission enhancement in NW array LEDs at different temperatures and couple the results to carrier transport simulations. Our results show that the extraction efficiency
To enable a more detailed analysis of our recent studies of intracavity double diode structures (DDSs), new simulation tools are needed. Such simulation models must account for both charge and photon transport in the studied structures, consisting of optically coupled AlGaAs/GaAs double heterojunction light emitting diode (LED) and GaAs p-n-homojunction photodiode (PD) structure, enclosed within a
Impact of decisions in the design process is initially high and declines as the design matures. However, few computational tools are available for the early design phase, thus an opportunity exists to create such tools. New technology opens up new possibilities to create new and novel computational tools. In this work an existing application is adapted for a new novel 3D input device that is named
This paper presents a study exploring the capabilities of a new method, described by Åkesson and Alic [1], which extends the capabilities of the algebraic graphic statics method, by Van Mele and Block [11]. The new method extends the algebraic graphic statics method by making it bi-directional i.e. allowing for determination of an updated form diagram by making direct interactive manipulations of
This paper presents imaging results from measurements of an industrially manufactured composite test panel, utilizing two introduced algorithms for data post-processing. The system employs a planar near-field scanning set-up for characterizing defects in composite panels in the 50–67 GHz band, and can be considered as a complementary diagnostic tool for non-destructive testing purposes.
The negative-ion fragmentation of formic acid (HCOOH) is studied with negative- and positive-ion coincidence spectroscopy. We report four-body ionic fragmentation where up to three positive ions are collected in coincidence with one negative ion. We report yields for 21 three-body channels and five four-body channels. More than 80% of all negative-ion fragmentation involves production of O-, and i
Caffeine is one of the most widely used drugs in the world. In the brain, caffeine acts as an antagonist for the adenosine A1 and A2B receptors. Since A1 receptors are highly concentrated in the cortex of the cerebellum, we hypothesized that caffeine could potentially affect learning tasks that require the cerebellar cortex, such as eyeblink conditioning. To test this hypothesis, we examined the e
Globalt sett lever 8 av 10 människor i miljöer där luftföroreningar i form av små luftburna partiklar ligger över riktlinjer satta av världshälsoorganisationen WHO. WHO uppskattar även att luftföroreningar ligger bakom 3.7 miljoner dödsfall varje år. Värst är det i delar av Asien, men även här i Sverige är luftkvaliteten ett problem; i Skåne t ex bedöms den genomsnittliga livslängden förkortas medAtmospheric aerosols affect climate, but to what degree still remains one of the largest uncertainties in global climate models. To improve the representation of aerosols in future climate models we need a greater understanding of aerosol processes. In this thesis the process-based model ADCHEM has been used and further developed to study aerosol processes. Specifically; new particle formation and
Recently, the iterative adaptive approach (IAA) was adopted to allow for the estimation of high-resolution scanning radar images. In this letter, we further develop this approach by introducing a range-recursive IAA (IAA-RR) formulation allowing for a computationally efficient updating of the resulting estimates along range. Besides exploiting the rich matrix structure to mitigate the computationa
