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Improving risk prediction in heart failure using machine learning
Background: Predicting mortality is important in patients with heart failure (HF). However, current strategies for predicting risk are only modestly successful, likely because they are derived from statistical analysis methods that fail to capture prognostic information in large data sets containing multi-dimensional interactions. Methods and results: We used a machine learning algorithm to captur
The impact of endurance training and table soccer on brain metabolites in schizophrenia
Higher glutamate and glutamine (together: Glx) and lower N-acetyl-aspartate (NAA) levels were reported in schizophrenia. Endurance training normalizes NAA in the hippocampus, but its effects on other metabolites in the brain and the relationship of metabolites to clinical symptoms remain unknown. For 12 weeks, 20 schizophrenia inpatients (14 men, 6 women) and 23 healthy controls (16 men, 7 women)
Diagnosis and long-term outcome in dogs with acute onset intracranial signs
Objectives: To investigate dogs with acute onset of intracranial signs suspected of stroke by primary veterinary clinicians, and establish possible differential diagnoses and long-term outcome. In addition, serum C-reactive protein and plasma cytokines were investigated as potential biomarkers of disease. Materials and Methods: All cases were evaluated by neurologic examination, routine haematolog
Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype
SUGCT (C7orf10) is a mitochondrial enzyme that synthesizes glutaryl-CoA from glutarate in tryptophan and lysine catabolism, but it has not been studied in vivo. Although mutations in Sugct lead to Glutaric Aciduria Type 3 disease in humans, patients remain largely asymptomatic despite high levels of glutarate in the urine. To study the disease mechanism, we generated SugctKO mice and uncovered imb
The chemokine CXCL16 is a new biomarker for lymph node analysis of colon cancer outcome
Chemokines are important in the development and progression of tumors. We investigated the expression of CXCL14 and CXCL16 in colon cancer. Expression of mRNA was assessed in primary tumors and lymph nodes and CXCL16 mRNA levels were correlated to patient’s survival. Protein expression was investigated by two-color immunofluorescence and immunomorphometry. CXCL14 and CXCL16 mRNA levels and protein
Risk-Adapted Starting Age of Screening for Relatives of Patients with Breast Cancer
Importance: Breast cancer screening guidelines acknowledge the need for earlier screening for women at increased risk but provide limited guidance for women with a family history of breast cancer. A risk-adapted starting age of screening for relatives of patients with breast cancer may help supplement current screening guidelines. Objective: To identify the risk-adapted starting age of breast canc
A Convivial Journey : From Diversity in Istanbul to Solidarity with Refugees in Denmark
This chapter presents my analytical journey from conviviality, a concept used for analysing diversity in Istanbul to overcome the pitfalls of multiculturalism and coexistence theories, to the development of the concept of convivial solidarity for the analysis of transnational civil society organisations that support refugees and migrants in Denmark. Convivial solidarity is my construct and I use i
Higher-order tree-level amplitudes in the nonlinear sigma model
We present a generalisation of the flavour-ordering method applied to the chiral nonlinear sigma model with any number of flavours. We use an extended Lagrangian with terms containing any number of derivatives, organised in a power-counting hierarchy. The method allows diagrammatic computations at tree-level with any number of legs at any order in the power-counting. Using an automated implementat
Increased genetic marker density reveals high levels of admixture between red deer and introduced Japanese sika in Kintyre, Scotland
Hybridization is a natural process at species range boundaries, but increasing numbers of species are hybridizing due to direct or indirect human activities. In such cases of anthropogenic hybridization, subsequent introgression can threaten the survival of native species. To date, many such systems have been studied with too few genetic markers to assess the level of threat resulting from advance
Analysis of the LIF/Mie ratio from individual droplets for planar droplet sizing : Application to gasoline fuels and their mixtures with ethanol
In this work, the possibility of using planar droplet sizing (PDS) based on laser-induced fluorescence (LIF) and Mie scattering was investigated within the framework of measuring the droplet Sauter mean diameter (SMD) of direct-injection spark-ignition (DISI) spray systems. For this purpose, LIF and Mie signals of monodisperse fuel droplets produced by a droplet generator were studied at engine re
Influence of root distribution on preferential flow in deciduous and coniferous forest soils
Root-induced channels are the primary controlling factors for rapid movement of water and solute in forest soils. To explore the effects of root distribution on preferential flow during rainfall events, deciduous (Quercus variabilis BI.) and coniferous forest (Platycladus orientalis (L.) Franco) sites were selected to conduct dual-tracer experiments (Brilliant Blue FCF and Bromide [Br-]). Each plo
Trade in Services in the New Century
Concerns have been raised about the potential adverse effects of liberalizing trade in services under the GATS framework on equity, costs, distribution, availability of services and sovereignty of governments in defining their national objectives. These concerns have been voiced in poor countries in case of such social service sectors as health and education. Critics have stressed the need for an
An ecological warning line of oasis evolvement and its application in arid inland basins
Based on a comparative study of the social economic development and the water resources characteristics in 13 arid inland basins of north-western China, it is pointed out that oasis will move from lower reach to upper reach in the circumstances of lower water availability per capita and poorer social economic structures. A significant ecological warning line and warning interval of oasis evolvemen
Gender and age differences in symptoms and health-related quality of life in patients with atrial fibrillation referred for catheter ablation
Midnight salivary cortisol secretion and the use of antidepressants were associated with abdominal obesity in women with type 1 diabetes : A cross sectional study
Background: Abdominal obesity is a risk factor for cardiovascular disease. The aim was to explore the influence of midnight salivary cortisol (MSC), antidepressants and sex on abdominal obesity in type 1 diabetes (T1D). We controlled for physical inactivity, smoking, depression and alexithymia. Methods: Cross sectional study of 190 T1D patients (86 women/104 men, 18-59 years, diabetes duration 1-5
Natural sources and experimental generation of bioaerosols : Challenges and perspectives
Experimental aerosol generation methods aim to represent natural processes; however, the complexity is not always captured and unforeseen variability may be introduced into the data. The current practices for natural and experimental aerosol generation techniques are reviewed here. Recommendations for best practice are presented, and include characterization of starting material and spray fluid, r
Search for heavy neutral leptons in decays of W bosons produced in 13 TeV pp collisions using prompt and displaced signatures with the ATLAS detector
The problems of neutrino masses, matter-antimatter asymmetry, and dark matter could be successfully addressed by postulating right-handed neutrinos with Majorana masses below the electroweak scale. In this work, leptonic decays of W bosons extracted from 32.9 fb−1 to 36.1 fb−1 of 13 TeV proton–proton collisions at the LHC are used to search for heavy neutral leptons (HNLs) that are produced throug
In conversation with Elizabeth Minnich
At the conference of the International Society for the Scholarship of Teaching and Learning (ISSOTL) in Bergen, Norway (October 2018), we were privileged to have heard a lecture by Elizabeth Minnich, “People who are not thinking are capable of anything: What are students learning, how are students learning it, and does it make them better people?”In November 2018, as a follow-up to the lecture, Ch
Indirect Calorimetry Overestimates Oxygen Consumption in Young Children : Caution is Advised Using Direct Fick Method as a Reference Method in Cardiac Output Comparison Studies
Direct Fick method is considered a standard reference method for estimation of cardiac output. It relies on indirect calorimetry to measure oxygen consumption. This is important as only a minor measurement error in oxygen consumption can result in false estimation of cardiac output. A number of studies have shown that indirect calorimetry overestimates oxygen consumption in adults. The aim of this