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Berlin is Hotter Than Silicon Valley! How Networking Temperature Shapes Entrepreneurs’ Networking Across Social Contexts

Our study contributes a contextual perspective on entrepreneurs’ networking, shifting focus from individual-level network structure and networking activities toward understanding networking as a multilevel process involving individual and contextual mechanisms. Through a multiple case study of entrepreneurs in Silicon Valley and Berlin, we introduce networking temperature as novel concept that cap

Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway

The nucleolar surveillance pathway monitors nucleolar integrity and responds to nucleolar stress by mediating binding of ribosomal proteins to MDM2, resulting in p53 accumulation. Inappropriate pathway activation is implicated in the pathogenesis of ribosomopathies, while drugs selectively activating the pathway are in trials for cancer. Despite this, the molecular mechanism(s) regulating this pro

Science, Dualities and the Phenomenological Map

We present an epistemological schema of natural sciences inspired by Peirce’s pragmaticist view, stressing the role of the phenomenological map, that connects reality and our ideas about it. The schema has a recognisable mathematical/logical structure which allows to explore some of its consequences. We show that seemingly independent principles as the requirement of reproducibility of experiments

Weighted cue integration for straight-line orientation

Animals commonly integrate multiple sources of information to guide their behavior. Among insects, previous studies have suggested that the relative reliability of cues affects their weighting in behavior, but have not systematically explored how well alternative integration strategies can account for the observed directional choices. Here, we characterize the directional reliability of an ersatz

The Effect of Two Midwives During the Second Stage of Labour to Reduce Severe Perineal Trauma (Oneplus) : A Multicentre, Randomized Controlled Trial in Sweden

In many high-income countries, severe perinatal trauma (SPT), affecting the anal sphincter muscle complex, has been on the rise over the last decade. However, effective strategies to prevent SPT are scarce. In randomized controlled trials, only perineal warm compresses and massage have shown benefit. Other cohort studies have shown that prevention models involving several components can decrease t

Intermediate care in caring for dementia, the point of view of general practitioners : A key informant survey across Europe

Background: Intermediate care is often defined as healthcare occurring somewhere between traditional primary (community) and secondary (hospital) care settings. High quality intermediate care is important in dementia, may prevent caregiver burnout and also lead to optimal care for people with dementia. However, very little is known about the point of intermediate care for persons with dementia in

Standard Model estimate of K+ →π+4e branching ratio

The branching ratio of the K+→π+e+e-e+e- (K+→π+4e) decay is calculated at leading order in the Standard Model. The dominance of the neutral-pion pole determines the overall branching ratio to be B(K+→π+4e)=B(K+→π+π0)B(π0→4e)≈7.0(3)×10-6. The significance of this contribution is very much concentrated in the context of the whole available phase space, throughout most of which the one-photon-exchang

The Phenomenology of Semiosis : Approaches to the Gap between the Encyclopaedia and the Porphyrian Tree Spanned by Sedimentation

When putting semiotics and phenomenology in juxtaposition, the first task necessarily is to find out what a study of meaning, conceiving of itself as an empirical science, has to do with a philosophical school, the business of which it is to secure the epistemological foundations of all the sciences (broadly understood). Our answer, in short (but we will go at some length to show it), is that sinc

Use of sorbitan sesquioleate in patch test preparations and patch testing with the substance-What do our results mean?

BACKGROUND: Sorbitan sesquioleate (SSO) is a sorbitan fatty acid ester, an emulsifier used in topical products and certain patch test preparations. SSO may affect the patch test results. It has been debated whether to include the substance in the baseline series to avoid misinterpretation of the results.OBJECTIVES: To report the prevalence and simultaneous reactions of SSO with other patch test pr

Molecular Imaging for Localized Prostate Cancer: Analysis of 2 Prospective Phase 0 Trials of PSMA Targeted Immuno-PET and –SPECT, and Implications for the Radiation Oncologist

Purpose/Objective(s): To report the efficacy and utility of PSMA-based molecular targeted imaging in localized prostate cancer using 111In-J591 SPECT and 89Zr-J591 immuno-PET.Materials/Methods: Initiated in 2010, two sequential phase 0 prospective studies were performed on a total of 19 patients evaluating the roles of 111In-J591 SPECT and 89Zr-J591 immuno-PET. All patients had a baseline MRI foll

Fatty acid 16:1ω5 as a proxy for arbuscular mycorrhizal fungal biomass : current challenges and ways forward

Fatty acid biomarkers have emerged as a useful tool to quantify biomass of various microbial groups. Here we focus on the frequent use of the fatty acid 16:1ω5 as a biomarker for arbuscular mycorrhizal (AM) fungi in soils. We highlight some issues with current applications of this method and use several examples from the literature to show that the phospholipid fatty acid (PLFA) 16:1ω5 can occur i

Community-onset urosepsis : incidence and risk factors for 30-day mortality–a retrospective cohort study

Background: Urosepsis is a life-threatening condition that needs to be addressed without delay. Two critical issues in its management are: (1) Appropriate empirical antibiotic therapy, considering the patients general condition, comorbidity, and the pathogen expected; and (2) Timing of imaging to identify obstruction requiring decompression. Objectives: To identify risk factors associated with 30-

Active and Physics-Based Human Pose Reconstruction

Perceiving humans is an important and complex problem within computervision. Its significance is derived from its numerous applications, suchas human-robot interaction, virtual reality, markerless motion capture,and human tracking for autonomous driving. The difficulty lies in thevariability in human appearance, physique, and plausible body poses. Inreal-world scenes, this is further exacerbated b

Fluid Management, Intra-Abdominal Hypertension and the Abdominal Compartment Syndrome : A Narrative Review

Background: General pathophysiological mechanisms regarding associations between fluid administration and intra-abdominal hypertension (IAH) are evident, but specific effects of type, amount, and timing of fluids are less clear. Objectives: This review aims to summarize current knowledge on associations between fluid administration and intra-abdominal pressure (IAP) and fluid management in patient