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Physiotherapy in primary care for working-age patients with early back and neck pain. Screening tools, interventions and outcomes.

Besvär från rörelseorganen, framför allt från rygg och nacke är en av de vanligaste anledningarna till sjukfrånvaro i västvärlden. Patienter med dessa besvär utgör en stor andel av de som söker primärvården där fysioterapi ofta är första linjens vård. Rygg och nacksmärta kan orsaka nedsatt funktion och aktivitetsförmåga vilket ofta innebär en betydande förlust av livskvaliteten samt ekonomiska konPatients with back and neck pain are frequently seen in primary care, where they are directed to physiotherapy as first-line treatment. The condition affects both the individual, by causing pain and disability, and society, because of high costs caused by work disability and health care consumption. Clinicians need tools to identify, at an early stage, patients at risk of poor outcome, in order to

Online Learning and Placement Algorithms for Efficient Delivery of User Generated Contents in Telco-CDNs

User generated content (UGC) makes up a significant portion of Internet traffic. As opposed to other content, UGC has so far been left outside over-the-top providing network operators content distribution networks (telco-CDN) due to the difficulty in determining optimised placement of such content. The side effect of this is that UGC content is not placed close to end users and therefore occupy un

Handledare på dubbla stolar

En studierektor för doktorander bör inte samtidigt vara handledare eller biträdande handledare. Intressekonflikter kan uppstå. En doktorand kan hamna i en onödig och svår valsituation.

Von Willebrand factor alloantibodies in type 3 von Willebrand disease

The development of neutralizing antibodies is a rare complication of von Willebrand disease treatment. In major surgical procedures for severe forms of the disease, the recognition of ineffective therapy and alternative treatment protocols are lifesaving. We report the case of a 6-year-old girl with type 3 von Willebrand disease in whom inhibitors were sought due to ineffective haemostasis togethe

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association analysis with in silico genomic feature annotations. We defined 205 independent risk-associated signals with the set of credible causal variants in each one. In parallel, we used a Ba

EuRoSDR GeoBIM project a study in Europe on how to use the potentials of BIM and GEO data in practice

In both the Geo and BIM domains, it is widely acknowledged that the integration of geo-data and BIM-data is beneficial and a crucial step in facing the multi-disciplinary challenges of our built environment. The result of this integration - broadly termed as GeoBIM - has a range of potential uses from district study to road safety. However, from the data perspective, this integration raises the qu

Pathogenic implications of distinct patterns of iron and zinc in chronic MS lesions

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) in which oligodendrocytes, the CNS cells that stain most robustly for iron and myelin are the targets of injury. Metals are essential for normal CNS functioning, and metal imbalances have been linked to demyelination and neurodegeneration. Using a multidisciplinary approach involving synchro

Reliability of Speech Variables and Speech-Related Quality Indicators in the Swedish Cleft Lip and Palate Registry

Objective: To assess the reliability of speech variables and speech-related quality indicators in the Swedish quality registry for cleft lip and palate (CLP). Design: Retrospective study. Setting: Primary care university hospitals. Participants: Fifty-two 5-year-old children with unilateral CLP and 41 with bilateral CLP. Main Outcome Measures: Registry data for “percent nonoral errors” and “percei

Lean Startup and the business model : Experimenting for novelty and impact

Lean Startup has been impacting how startups and incumbents innovate their business models. However, academic understanding of Lean Startup and the associated experimentation process is only emerging. Recent academic critique of Lean Startup by Felin and colleagues (in press) highlights the inadequate guidance provided for hypotheses generation; limits of experiential learning from customer feedba

Limiting conditions for a sustained flame over condensed fuels : Analysis by experiments and stagnant layer theory

Ignition and extinction characteristics of a material determine whether a fire will be initiated and grow. In fire safety engineering, where modellers deal with a multitude of materials, simplified thresholds are commonly used to determine when ignition and extinction occur.Such a threshold is the critical mass flux, which describes when sufficient fuel vapour is produced to support sustained flam

Efficacy and safety of dronedarone in patients with a prior ablation for atrial fibrillation/flutter : Insights from the ATHENA study

Background: The role of antiarrhythmic drugs for atrial fibrillation/atrial flutter (AF/AFL) after catheter ablation is not well established. Hypothesis: We hypothesized that changing the myocardial substrate by ablation may alter the responsiveness to dronedarone. Methods: We assessed the efficacy and safety of dronedarone in the treatment of paroxysmal/persistent atrial fibrillation/atrial flutt